Intravenous administration preparation extracted from marsdenia tenacissima stem

A technology of intravenous administration and customs clearance, which can be applied in medical preparations containing active ingredients, drug delivery, and drug combinations, etc., and can solve the problems of complex extraction process, cumbersome actual operation, and improvement of extraction process.

Active Publication Date: 2008-11-19
NANJING SANHOME PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein CN1076859A, the extraction process is too complicated, the large production cost is large and the actual operation is cumbersome, and there is no mention of removing potassium ions in the preparation process
In CN1546055A, scopoletin is used as the quality control index, and the pharmacological effects of scopoletin are analgesic and anti-inflammatory, so taking scopoletin as the quality control index cannot guarantee the amount of effective anticancer components of the product. For potassium The removal of ions is also not stated
CN1589829A only makes the extract of Tengguan Teng into capsules, and does not improve the extraction process
Commercially available Xiaoaiping preparations are mostly injections and tablets, and there are no infusion preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of Xiaoaiping injection preparation

[0027] Taking the preparation of 50 Xiaoaiping injections as an example, the specification of the preparation is 20ml / bottle. Add water to 1000g of Tengguan vine and decoct 3 times, the amount of water added is 10 times, 8 times, and 6 times the weight of Tengguan vine in turn, and the decocting time is 1.5 hours, 1 hour, and 0.8 hours in turn. Combine the decoctions, filter, and concentrate the filtrate to The density is 1.02 (about 400ml), let it cool, add 8 times the amount of 85% ethanol (volume ratio to the concentrated solution), stir well, place at 4°C for 24 hours, filter, and concentrate the filtrate to a density of 1.03 (about 300ml), Filter, add 8 times the amount of ethanol (volume ratio to the concentrated solution), stir well, place at -15°C for 48 hours, filter, concentrate the filtrate until there is no alcohol smell, place at 4°C for 48 hours, filter, concentrate the filtrate to density 1....

Embodiment 2

[0028] Embodiment 2: the preparation of Xiaoaiping injection preparation

[0029] Taking the preparation of 50 Xiaoaiping injections as an example, the specification of the preparation is 20ml / bottle. Add water to 1000g of Tengguan vine and decoct 3 times, the amount of water added is 10 times, 8 times, and 6 times the weight of Tengguan vine in turn, and the decocting time is 1.5 hours, 1 hour, and 0.8 hours in turn. Combine the decoctions, filter, and concentrate the filtrate to The density is 1.03 (about 400ml), let it cool, add 8 times the amount of 85% ethanol (volume ratio to the concentrated solution), stir well, place at 4°C for 24 hours, filter, and concentrate the filtrate to a density of 1.04 (about 300ml), Filter, add 8 times the amount of ethanol (volume ratio to the concentrated solution), stir well, place at 4°C for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, place at 4°C for 48 hours, filter, concentrate the filtrate t...

Embodiment 3

[0030] Embodiment 3: the preparation of Xiaoaiping injection preparation

[0031]Taking the preparation of 50 Xiaoaiping injections as an example, the specification of the preparation is 20ml / bottle. Add water to 1000g of Tengguan vine and decoct 3 times. The amount of water added is 10 times, 8 times, and 8 times the weight of Tengguan vine. The decocting time is 1.5 hours, 1 hour, and 1 hour. The density is 1.02 (about 400ml), let it cool, add 10 times the amount of 85% ethanol (volume ratio to the concentrated solution), stir well, place at 4°C for 26 hours, filter, and concentrate the filtrate to a density of 1.02 (about 300ml), Filter, add 10 times the amount of ethanol (volume ratio to the concentrated solution), stir well, place at -5°C for 50 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, place at 4°C for 50 hours, filter, and concentrate the filtrate to The density is 1.03 (about 200ml), and the extract is obtained. The extract i...

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PUM

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Abstract

The present invention relates to a venous administration preparation extracted from Chinese medicinal material marsdenia tenacissima. Its preparation process includes the following steps: firstly, extracting marsdenia tenacissima to obtain its extract, then adding medicinal material into said extract to make them into intravenous drip administration dosage forms, including injection preparation, glucose injection preparation and sodium chloride injection preparation.

Description

technical field [0001] The invention relates to extracting polysaccharides, alkaloids, saponins and the like as anticancer components from Tengguan vine, a traditional Chinese medicine, and making them into preparations for intravenous administration. Background technique [0002] Tongguanteng is also known as Wuguteng, Xiamiliteng and Tongguangsan, etc. Its extract has anti-tumor effects (see Jilin Traditional Chinese Medicine. January 2002. Volume 22. Issue 1, Chinese Folk Therapy. June 2003 Volume 11, No. 6, Henan Oncology Journal. 1993. Vol. 6. No. 3), the effective anticancer ingredients are polysaccharides, alkaloids, saponins, etc. (see the first edition of the Dictionary of Traditional Chinese Medicine. 1993.470). China has related patent application publications (seeing CN1076859A, CN1546055A and CN1589829A). Among them, the extraction process in CN1076859A is too complicated, the production cost is large and the actual operation is cumbersome, and the removal of p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/27A61K36/185A61K9/08A61P35/00
Inventor 张仓李玲
Owner NANJING SANHOME PHARMACEUTICAL CO LTD
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