Glycerin fructose sodium chloride injection and preparation process thereof

A sodium chloride injection and sodium chloride technology, applied in the direction of active ingredients of alkali/alkaline earth metal chlorides, active ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc., to solve safety problems and eliminate clinical safety hazards Effect

Inactive Publication Date: 2013-02-06
SICHUAN KELUN PHARMA RES INST CO LTD
View PDF5 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high quality requirements of this variety, the limit requirements of 5-hydroxymethylfurfural are extremely strict. In practice, a certain amount of antioxidants and auxiliary materials are used to solve this problem, which will bring certain safety problems of auxiliary materials. ;At the same time,...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0014] Conditions: stirring for 30 minutes. (5-Hydroxymethylfurfural is abbreviated as 5-HMF.)

[0015] Table 1 Selection of preparation temperature

[0016] condition

[0017] The test results in Table 1 show that low temperature is beneficial to the stability of fructose.

experiment example 2

[0019] Conditions: ultrafiltration tests 1, 2, and 3 were evaluated and verified by ultrafiltration membrane filtration; activated carbon 1 and 2 were evaluated and verified by adding activated carbon and then filtered with a 0.22um microporous membrane.

[0020] Table 2 Comparative test of ultrafiltration and activated carbon process

[0021] condition

Ultrafiltration test 1

Ultrafiltration test 2

Ultrafiltration test 3

Activated carbon 1

Activated carbon 2

endotoxin

Compliance

Compliance

Compliance

Compliance

Compliance

[0022] The test results in Table 2 show that ultrafiltration can remove the heat source in the injection, and can achieve the same effect as adding activated carbon.

[0023] All embodiments of the present invention can achieve the effects of the above experimental examples.

Embodiment 1

[0025] Add 540ml of water for injection to the preparation tank at a temperature of about 45°C, add 100g of glycerin and 9g of sodium chloride, stir to dissolve, filter into the dilution tank; add 50g of sterile fructose for injection to dissolve, add to the preparation volume of 1000ml, and measure the content And conform to the regulations, filter with 0.22um microporous membrane and ultrafiltration membrane, refill, sterilize, light check, pack and get final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a glycerin fructose sodium chloride injection and a preparation process thereof. According to the invention, the preparation method of the glycerin fructose sodium chloride injection comprises the following steps: preparing 50-150 parts of glycerin, 5-15 parts of sodium chloride and 10-100 parts of injection fructose by weight at a low temperature; and ultra-filtering a prepared product, wherein the low temperature is 30-60 DEG C. As the glycerin fructose sodium chloride injection disclosed by the invention is prepared by using a new technology and using a novel low temperature preparation and ultrafiltration technology, and any auxiliary material and active carbon are not needed in the preparation process, the instability problem of the fructose (5-hydroxymethyl furfural is generated) and the safety problem of active carbon residue are solved, and clinical potential safety hazards are eliminated.

Description

technical field [0001] The invention relates to an injection and a preparation process thereof, in particular to a glycerol fructose sodium chloride injection and a preparation process thereof. Background technique [0002] Glycerin Fructose Sodium Chloride Injection is clinically a drug for lowering intracranial pressure, with definite curative effect, and has been well received by doctors and patients. However, due to the high quality requirements of this variety, the limit requirements of 5-hydroxymethylfurfural are extremely strict. In practice, a certain amount of antioxidants and auxiliary materials are used to solve this problem, which will bring certain safety problems of auxiliary materials. At the same time, for the requirements of intravenous administration, a large amount of activated carbon needs to be used to decolorize and remove impurities. Since the activated carbon cannot be completely removed and remains in the injection, it will accumulate in the blood ve...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K33/14A61K9/08A61P25/00A61K31/047A61K31/7004
Inventor 欧苏梁隆程志鹏
Owner SICHUAN KELUN PHARMA RES INST CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap