Preparation method of high-purity breviscapinun material used by breviscapinun injection

A high-purity technology of breviscapine, which is applied in the preparation of sugar derivatives, chemical instruments and methods, and medical preparations containing active ingredients, etc., can solve the high-level problems of related substances, achieve enhanced curative effect, reduce the content of related substances, and ensure safety sex enhancing effect

Active Publication Date: 2011-09-21
吉林四长制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly due to the simple extraction steps of crude scutellarin, resulting in high levels of related substances, after clinical use, occasional itching, chest tightness, fatigue, rash, palpitations and other phenomena all over the body

Method used

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  • Preparation method of high-purity breviscapinun material used by breviscapinun injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take the crude product of breviscapine and fully dissolve it with an appropriate amount of water, adjust the pH value of the solution to 4, and dissolve it completely, then add ethanol solution to make the ethanol concentration reach 50%, let it stand overnight, precipitate and filter, and then dissolve it with ethanol solution to make it The concentration of ethanol reaches 20%, the pH value is adjusted to 1, the precipitate is fully stirred and precipitated, the precipitate is precipitated after standing, filtered, the precipitate is washed with purified water to neutrality, and then ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 10,000, the ultrafiltration The filtrate was concentrated under reduced pressure and dried in vacuo to obtain high-purity scutellarin.

[0023] The high-purity breviscapine raw material is compatible with glucose or sodium chloride to prepare breviscapine glucose injection and breviscapine sodium chloride inj...

Embodiment 2

[0026] Take the crude product of breviscapine and fully dissolve it with an appropriate amount of water, adjust the pH value of the solution to 5, and dissolve it completely, then add ethanol solution to make the ethanol concentration reach 55%, let it stand overnight, precipitate and filter, and then dissolve it with ethanol solution to make it The concentration of ethanol reaches 25%, the pH value is adjusted to 1-3, the precipitate is fully stirred and precipitated, the precipitate is precipitated after standing, filtered, the precipitate is washed with purified water to neutrality, and then ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 20,000. Concentrate the ultrafiltrate under reduced pressure and dry it in vacuum to obtain high-purity scutellarin.

[0027] The high-purity breviscapine raw material is compatible with glucose or sodium chloride to prepare breviscapine glucose injection and breviscapine sodium chloride injection. The spe...

Embodiment 3

[0030] Take the crude product of breviscapine and fully dissolve it with an appropriate amount of water, adjust the pH value of the solution to 6, and make it completely dissolved, then add ethanol solution to make the ethanol concentration reach 60%, let it stand overnight, precipitate and filter, and then dissolve it with ethanol solution to make it The concentration of ethanol reaches 30%, the pH value is adjusted to 2, the precipitate is fully stirred and precipitated, the precipitate is precipitated after standing, filtered, the precipitate is washed with purified water to neutrality, and then ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 30,000, the ultrafiltration The filtrate was concentrated under reduced pressure and dried in vacuo to obtain high-purity scutellarin.

[0031] The high-purity breviscapine raw material is compatible with glucose or sodium chloride to prepare breviscapine glucose injection and breviscapine sodium chlori...

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PUM

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Abstract

The invention provides a preparation method of high-purity breviscapinun material used by a breviscapinun injection. The method comprises the preparation steps of: carrying out dissolving, alcohol precipitation, acid precipitation, ultrafitration and the like on the breviscapinun to obtain the high-purity breviscapinun material. The purity of the high-purity breviscapinun material can achieve more than 98 percent by detection through high performance liquid chromatography, and the high-purity breviscapinun material can be used for preparing large-capacity injection such as breviscapinun sodium chloride injection or breviscapinun glucose Injection.

Description

technical field [0001] The invention relates to a refinement method of scutellarin, in particular to a scutellarin extract extracted from scutellarin and a preparation method of the extract, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Breviscapine is a total flavonoid extracted from the dried whole plant of Breviscapus breviscapus, also known as Erigeron breviscapine, in the family Asteraceae. B is its main active ingredient. The chemical name of scutellarin (also known as scutellarin, scutellarin) is 4′, 5, 6-trihydroxyflavone-7-0-glucuronide, insoluble in water, and soluble in methanol, ethanol and acetone It is also very small, hardly soluble in water under acidic conditions, and can form salts with inorganic bases such as sodium hydroxide, carbonate, phosphate or organic bases such as citrate and meglumine, and dissolve in water under alkaline conditions. [0003] Ischemic encephalopathy, such as in patients with c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048C07H17/07C07H1/08A61P9/10A61K9/08A61K9/19
Inventor 时敬文
Owner 吉林四长制药有限公司
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