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Novel route for administering hairy holly injection and preparation process thereof

A route of administration and injection technology, applied in the new route of administration of Maodongqing injection and the field of preparation technology, can solve the problems of swelling and pain, slow speed, small dose and the like

Inactive Publication Date: 2006-02-15
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, in terms of clinical application, Mao Dongqing injection adopts the intramuscular injection method, which is absorbed through the tissue at a slower rate and with a smaller dose, which not only increases the pain of the patient, but also causes local induration of the injection, even swelling and pain, and secondary infection. Frequent injections can also easily lead to "Gluteal Muscle Contracture"
This medication method obviously limits its clinical application
Therefore, in response to this problem, we have developed an intravenous route of administration, which overcomes the shortcomings of slow absorption and long onset time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of injection of the present invention:

[0053] Take 600g of Maodongqing, add water for injection and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15-1.18 (50°C), add Ethanol to make the alcohol content reach 70%, refrigerated for 24 hours, filtered, the filtrate was decompressed to recover ethanol, allowed to cool to room temperature, added water for injection to a relative density of 1.08, adjusted the pH value to 2.0-3.0 with 10% hydrochloric acid solution, and statically Place the precipitate, filter, adjust the pH value of the filtrate to 6.0-6.5 with 20% sodium hydroxide solution, place it in refrigeration for 12 hours, filter, concentrate the filtrate under reduced pressure to a relative density of 1.20-1.23 (50°C), add ethanol to make The ethanol content reaches 75%, refrigerated for ...

Embodiment 2

[0055] The preparation method of freeze-dried powder injection of the present invention:

[0056] Take 600g of Maodongqing, add water for injection and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15-1.18 (50°C), add Ethanol to make the alcohol content reach 70%, refrigerated for 24 hours, filtered, the filtrate was decompressed to recover ethanol, allowed to cool to room temperature, added water for injection to a relative density of 1.08, adjusted the pH value to 2.0-3.0 with 10% hydrochloric acid solution, and statically Place the precipitate, filter, adjust the pH value of the filtrate to 6.0-6.5 with 20% sodium hydroxide solution, place it in refrigeration for 12 hours, filter, concentrate the filtrate under reduced pressure to a relative density of 1.20-1.23 (50°C), add ethanol to make The ethanol content reaches 75...

Embodiment 3

[0058] The preparation method of sterile powder of the present invention:

[0059] Take 600g of Maodongqing, add water for injection and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15-1.18 (50°C), add Ethanol to make the alcohol content reach 70%, refrigerated for 24 hours, filtered, the filtrate was decompressed to recover ethanol, allowed to cool to room temperature, added water for injection to a relative density of 1.08, adjusted the pH value to 2.0-3.0 with 10% hydrochloric acid solution, and statically Place the precipitate, filter, adjust the pH value of the filtrate to 6.0-6.5 with 20% sodium hydroxide solution, place it in refrigeration for 12 hours, filter, concentrate the filtrate under reduced pressure to a relative density of 1.20-1.23 (50°C), add ethanol to make The ethanol content reaches 75%, and it is st...

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Abstract

The invention relates to the novel administration methods of traditional medicinal injection for treating coronary atherosclerotic heart disease, thrombolysis in myocardial infarction, center syrup liquid chorioretintis and children's pneumonia, and the process for its preparation. The invention is prepared from pubescent holly root, freeze-dried powder, germ-free powder, 5% glucose injection, 5% sodium chloride injection through extracting with water, decompression concentrating, alcohol depositing, filtrating, adjusting pH, filtrating, charging water for injection into the filter liquor. A novel administration method of intra-vascular injection is provided.

Description

Technical field: [0001] The invention relates to a new administration route and a preparation process of Maodongqing injection. technical background: [0002] Cardiovascular disease, such as coronary heart disease and hypertension, is the main cause of human disease and death, accounting for one-third of the total mortality rate, and its mortality rate has surpassed that of cancer in China. Moreover, with the improvement of living standards, the number of patients is increasing, which poses a huge threat to the lives of patients. At the same time, patients often need to take medicine for a long time or for a lifetime, which seriously affects the quality of life and imposes a heavy burden on patients' families and even the whole society. [0003] At present, there are many Chinese and Western medicines for the treatment of coronary heart disease, but the western medicines have some side effects, and there are almost no effective methods for the treatment of cardiovascular dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/08A61K9/14A61K9/19A61P9/10
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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