Pemetrexed salt and preparation method thereof

A technology of pemetrexed dipotassium salt and pemetrexed, which is applied in the field of pemetrexed salt, pemetrexed salt and preparation thereof, and can solve the problems of poor water solubility, inconvenient storage, high toxicity of ethylenediamine salt, etc. question
CN104098573AInactive Publication Date: 2014-10-15CHONGQING PHARMA RES INST
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
CHONGQING PHARMA RES INST
Publication Date
2014-10-15
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a pemetrexed salt and a preparation method and use thereof, the pemetrexed salt can be dipotassium salt, arginine salt, heme-L-lysinate salt and tromethamine salt of the pemetrexed, and the pemetrexed salt can be used for treatment of various cancers such as mesothelioma, lung cancer and the like.
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Description

technical field

[0001] The invention relates to the fields of synthetic organic chemistry and pharmacy, in particular to a pemetrexed salt, a preparation method thereof, and an application of the pemetrexed salt. Background technique

[0002] Pemetrexed and its salts are disclosed as a variety of folate-dependent enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase ( GARFT) powerful inhibitors, such as EP334636, EP432677, CN1552713, CN101033227 and other reports, have anticancer activity.

[0003] The disodium salt of pemetrexed, that is, pemetrexed disodium (compound of formula I) has been listed in China, the United States, the European Union and other countries as an anticancer drug. Currently, pemetrexed disodium has been approved for use in the treatment of cancer. Four indications: (1) Combined with cisplatin for the treatment of inoperable malignant pleural mesothelioma, pemetrexed disodium is th...

Claims

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