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Gargle for relieving pain for oral inflammation disease

A technology for oral inflammation and gargle, which is applied in the field of medicine and achieves the effects of ensuring chemical stability, increasing water solubility and increasing stability

Inactive Publication Date: 2009-10-21
官培龙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no diclofenac sodium HP-β-CD inclusion to prepare oral rinse formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The following pharmaceutical composition for relieving pain and anti-inflammation of oral inflammatory disease is prepared according to the following ratio.

[0034] Diclofenac sodium (DS) 1.23g

[0035] HP-β-CD 4.43g

[0036] ---------------------------------

[0037] Add water for injection to 100.00ml

[0038] Preparation Process

[0039] Take 4.43g of HP-β-CD, add about 100ml of water for injection, heat to 80°C on a magnetic stirrer, stir to dissolve, slowly add 1.23g of diclofenac sodium under stirring (about 1000rpm), keep warm at 50°C-80°C ℃, stirring for 2h; stop heating, continue to stir to room temperature, and obtain DS-HP-β-CD clathrate solution. Take this solution and place it in the refrigerator for 12 hours, filter with suction and wash the precipitate, and dry the precipitate at 60°C. Weigh and determine its content. Obtain the diclofenac sodium hydroxypropyl-β-cyclodextrin inclusion in the composition of the present invention.

Embodiment 2

[0041] prescription

[0042] DS--HP-β-CD 1.23g (equivalent to containing diclofenac sodium 0.8g)

[0043] Lidocaine Hydrochloride 0.20g

[0044] Borax 15g

[0045] Boric acid 7.5g

[0046] Glycerin 35ml

[0047] Sodium bicarbonate 15g

[0048] Vitamin B12 0.06g

[0049] Tromethamine 0.60g

[0050] -----------------------------------

[0051] Add water for injection to 1000.00ml

[0052] Preparation Process

[0053] Take the prescribed amount of DS--HP-β-CD, add an appropriate amount of water for injection, add lidocaine hydrochloride, borax, boric acid, glycerin, sodium bicarbonate, vitamin B12, and tromethamine in sequence after fully dissolved, and heat to 80°C Stir for 15 minutes until it is fully dissolved, then cool down to 40°C, and make up to the full amount with water for injection to obtain the main drug stock solution of the composition of the present invention, whose pH value is 8.2.

Embodiment 3

[0055] prescription

[0056] DS--HP-β-CD 1.23g (equivalent to containing diclofenac sodium 0.8g)

[0057] Lidocaine Hydrochloride 0.20g

[0058] Borax 15g

[0059] Boric acid 7.5g

[0060] Glycerin 35ml

[0061] Sodium bicarbonate 15g

[0062] Vitamin B12 0.06g

[0063] Tromethamine 0.60g

[0064] Sucralose 6.8g

[0065] Peppermint essence 5ml

[0066] Sodium Benzoate 0.5g

[0067] ---------------------------------------

[0068] Add water for injection to 1000.00ml

[0069] Preparation Process

[0070] Take the prescribed amount of DS--HP-β-CD, add an appropriate amount of water for injection, add lidocaine hydrochloride, borax, boric acid, glycerin, sodium bicarbonate, vitamin B12, and tromethamine in sequence after fully dissolved, and heat to 80°C Stir for 15 minutes until completely dissolved, then lower the temperature to 40°C to obtain the main drug stock solution of the composition of the present invention. Then add sucralose, peppermint essence, sodium be...

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PUM

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Abstract

The invention belongs to the technical field of medicine, in particular to a drug composition of gargle which contains sodium dichlorophenolate and can relieve pain and be anti-inflammatory for the oral inflammation disease; wherein the drug composition comprises the following components by percentage: 0.10 to 30 percent of sodium dichlorophenolate hydroxypropyl-Beta-cyclodextrin inclusion (equal to 0.065 to 0.20 percent of concentration of sodium dichlorophenolate), 0.01 to 0.10 percent of lidocaine hydrochloride, 0.10 to 5.0 percent of borax, 0.1 to 2.0 percent of boric acid, 0.1 to 10 percent of glycerin, 0.10 to 5.0 percent of sodium bicarbonate, 0.001 to 0.10 percent of vitamin B12, 0.02 to 1.0 percent of tromethamine, 0.01 to 5.0 percent of sucralose, 0.10 to 5.0 percent of peppermint essence and 0.01 to 1.0 percent of sodium benzoate; a proper amount of pharmaceutical caramel color and water for injection is added till to reach the needed weight / volume concentration. All the above components are weighted by weight / volume percentage; the aqueous solution of the composition has the pH value of 6.5 to 9.0. The composition has little thrill to oral mucosa, stable storage for long time and good biological tolerance and has fast and long-lasting curative effect for relieving pain and being anti-inflammatory to the oral inflammation disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for analgesic and anti-inflammation oral cavity, and gargle. Pain medication efficacy. Background technique [0002] Oral inflammatory diseases, such as oral ulcers, pharyngitis, laryngitis, tonsillitis and gingivitis, etc., especially recurrent oral ulcer patients, have the characteristics of periodic and repeated attacks. Although oral inflammatory diseases are self-limiting to a certain extent, the pain caused after the onset seriously affects the patient's work and life. Pain in the lesion often affects eating and speech, leading to indigestion, fear of speaking, and mental anxiety, which often puts the patient in a lonely and painful environment, greatly reducing the quality of life (such as "toothache is not a disease, pain It's really terrible to look up", which is the portrayal of this kind of disease), and the lack of nutrition...

Claims

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Application Information

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IPC IPC(8): A61K33/22A61P1/02A61K31/047A61K31/133A61K31/167A61K31/196A61K31/714A61K33/00
Inventor 官培龙郭新洪
Owner 官培龙
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