Ozagrel tromethamine, compound, preparation method and application thereof

A technology of tromethamine and tromethamine salt, which is applied in the field of ozagrel tromethamine and compositions thereof, can solve the problems of water-soluble ozagrel salt purity defects, decreased stability and the like, and achieves The synthesis process is simple and feasible, with high stability and high anti-platelet aggregation effect.
CN101659640AActive Publication Date: 2010-03-03徐华
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
徐华
Publication Date
2010-03-03

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Abstract

The invention provides an ozagrel salt which is stable, has functions of inhibiting platelet aggregation and removing blood-vessel convulsion, has good water solubility, and is prepared into a compound suitable for clinical application. The new compound is ozagrel tromethamine; and the ozagrel and the tromethamine are prepared by reaction in a solvent. The compound has good water solubility, strong and long-term stability, and the functions of inhibiting platelet aggregation and removing blood-vessel convulsion.
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Description

technical field

[0001] The invention relates to a medicine with anti-platelet aggregation effect, in particular to an ozagrel salt, more specifically to ozagrel tromethamine and its composition, and a preparation method of the salt. It belongs to the field of medicinal chemistry and pharmaceutical preparation. Background technique

[0002] Ozagrel is a thromboxane synthase inhibitor, which can specifically inhibit thromboxane synthase, has anti-platelet aggregation and relieves vasospasm, can inhibit cerebral thrombosis and cerebral vasospasm, and can be used in subarachnoid space Improvement of cerebral ischemic symptoms after hemorrhagic surgery.

[0003] Due to the poor water solubility of ozagrel, the injection of ozagrel sodium salt is currently used more clinically, but ozagrel is unstable in aqueous solution and can be isomerized to generate cis-imidazole methyl cinnamon acid, and the long-term placement of the aqueous solution of sodium ozagrel in a glass container...

Claims

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