Method for synthesizing 1,2,4-butanetriol

Abstract

The invention provides a synthesis method for 1,2,4-tromethamine, comprising the following steps: the mixed solution of butene diol, tungsten acid and N-methyl morpholine, and epoxidizing agent are mixed through a mixer which is provided with two channel nozzles and arranged at the top part of a reactor, and then enter the reactor for reaction; the material in the reactor is sent to a nozzle at the top part of the reactor through a circulating pump for recycling use to collect epoxide; the epoxidizing agent is selected from oxygen-rich gases; in the presence of catalysts, the epoxide and ethanol go through hydrogenation reaction, then the 1,2,4-tromethamine is collected. The invention adopts oxygen-rich gas as epoxidizing agent and avoids the introduction of unnecessary media in the reaction system through the pre-mixing in a mixer provided with two channel nozzles; besides, the method of the invention has easily-controlled reaction temperature, less equipment investment and mild operating conditions, which does not use the traditional mercury catalyst and has no pollution to the environment; the reaction yield of the method can reach more than 95%, so the method is easy in industrialized implementation.

Description

technical field [0001] The invention relates to a method for synthesizing 1,2,4-butanetriol. Background technique [0002] 1,2,4-Butanetriol is an important chemical and chemical intermediate, which can replace glycerin in the military to prepare high-performance nitroglycerin explosives; in the pharmaceutical industry, butanetriol can be used to manufacture antiviral compounds and platelets Activator drugs; 1,2,4-Butanetriol also has important uses in the agrochemical industry. [0003] There are many synthetic methods for 1,2,4-butanetriol, such as the chemical reduction method of malate as raw material, the direct hydrolysis method of butenol as raw material, and the synthesis method of 2-butene-1,4-diol as raw material. Epoxidation hydrogenolysis two-step process and other processes. [0004] Among them, the epoxidation-hydrogenolysis two-step process and other processes were first reported by the German BASF company (DE264340). First, 2,3,-epoxy-1,4-diol was synthesiz...

AI Technical Summary

Problems solved by technology

However, the former uses borohydride as the original agent for chemical reduction, which requires stoichiometric or even more active hydrogen, and the raw material malate is not easy to obtain; while the atom economy of the direct hydrolysis reaction of butenol is very high, but There is a problem with bad choices

[0007] At present, there is also a synthetic method for preparing 1,2,4-butanetriol using mercury as a catalyst, which seriously pollutes the environment

[0008] In the existing industrialized production technology, in the epoxidation process of butenediol, the reagent used is hydrogen peroxide with a weight concentration of 30-35%, which not only requires equipment such as a high level tank, but also requires a large investment in equipment, and the hydrogen peroxide also contains 2,3 epoxy 1,4-butanetriol requires the addition of manganese dioxide, which introduces unnecessary components and brings difficulties to the subsequent purification. At the same time, since hydrogen peroxide is added dropwise to butene di Alcohol, therefore, causes the local concentration of the reaction system to be too high, the reaction temperature is not easy to control, the selectivity of the reaction is not good, and the reaction yield is not high

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