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Synthetic method of water-solubility biocompatibility monodisperse spherical gold nanometer crystals

A biocompatible, monodisperse technology, applied in the field of gold nanocrystal synthesis, can solve the problems of wide particle size distribution, unsatisfactory effect, inability to achieve high sensitivity, etc., and achieve the effect of good repeatability and simple operation.

Active Publication Date: 2013-06-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When it is larger than 20 nanometers, the particle size distribution is extremely wide, and high sensitivity, stability and selectivity of detection cannot be achieved
In addition, the current method of preparing large-sized gold nanocrystals is through the secondary seed growth method, and the effect is not ideal
This two-step synthesis method increases the difficulty of reproducible synthesis of monodisperse gold nanocrystals for researchers without chemical training background

Method used

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  • Synthetic method of water-solubility biocompatibility monodisperse spherical gold nanometer crystals

Examples

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Effect test

Embodiment 1

[0016] Soak the used glassware (100ml double-necked flask and 5ml serum bottle) in aqua regia for 2 hours, rinse with saturated sodium nitrate solution and ultrapure water several times, and dry them for later use. Using ultrapure water to calibrate with ultraviolet-visible spectroscopy, a 1% chloroauric acid solution was prepared. The required raw materials sodium citrate and silver nitrate were respectively configured into solutions with ultrapure water, wherein the mass percentage concentration of the sodium citrate solution was 3%, and the mass percentage concentration of the silver nitrate solution was 0.02%. In this example, glutathione was used as a stabilizer to stabilize gold nanocrystals, and a glutathione solution with a concentration of 1.5% by mass was prepared with ultrapure water. Then 47.5 milliliters of ultrapure water was placed in a 100 milliliter two-necked bottle, and heated rapidly to boiling. Then add 1.0 ml of ultrapure water, 0.5 ml of sodium citrate ...

Embodiment 2

[0018] Soak the used glassware (100ml double-necked flask and 5ml serum bottle) in aqua regia for 2 hours, rinse with saturated sodium nitrate solution and ultrapure water several times, and dry them for later use. With embodiment 1, preparation mass percentage concentration is the chloroauric acid solution of 1%, the mass percentage concentration is the sodium citrate solution of 2%, the mass percentage concentration is the silver nitrate solution of 0.01%. Place 47.5 ml of ultrapure water in a 100 ml two-necked bottle and heat it rapidly to boiling. Then 0.325 milliliters of ultrapure water, 1.25 milliliters of sodium citrate solution, 0.5 milliliters of chloroauric acid solution and 0.425 milliliters of silver nitrate solution were added to the 5 milliliter serum bottle for mixed reaction, and the color of the reaction solution changed from light yellow to dark green ( about 16 minutes), quickly transfer to boiling water. Keep boiling, heat to reflux for 30 minutes, and co...

Embodiment 3

[0020] With embodiment 1, preparation mass percentage concentration is the chloroauric acid solution of 1%, the mass percentage concentration is the sodium citrate solution of 3%, the mass percentage concentration is the silver nitrate solution of 0.08%. Place 47.5 ml of ultrapure water in a 100 ml two-necked bottle and heat it rapidly to boiling. Then add 1.075 ml of ultrapure water, 0.5 ml of sodium citrate solution, 0.5 ml of chloroauric acid solution and 0.425 ml of silver nitrate solution into a 5 ml serum bottle, mix and react for 5 minutes, then quickly transfer and inject into boiling water. Keep boiling, heat to reflux for 45 minutes, and cool to room temperature to obtain monodisperse spherical gold nanocrystals with a particle size of 12±1 nm. The transmission electron micrograph of the obtained gold nanocrystals is shown in c in the accompanying drawing.

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Abstract

Provided is a synthetic method of water-solubility biocompatibility monodisperse spherical gold nanometer crystals. The synthetic method of the water-solubility biocompatibility monodisperse spherical gold nanometer crystals comprises the following steps (1) using ultra-pure water to prepare a sodium citrate solution, a chloroauric acid solution, a silver nitrate solution and a glutathione solution or a tromethamine solution; (2) mixing the ultra-pure water, the sodium citrate solution, the chloroauric acid solution and the silver nitrate solution together to form a premixed solution, adding the glutathione solution or the tromethamine solution into the premixed solution to form a mixed solution; when the silver nitrate solution and the ultra-pure water are not used, solutions does not need to be mixed; (3) rapidly injecting the mixed solution into the boiling ultra-pure water which is used in a reaction, or directly injecting the solutions into the boiling ultra-pure water which is used in the reaction; and (4) carrying out heating reflux on the mixture, and naturally cooling extraction to room temperature. The synthetic method of the water-solubility biocompatibility monodisperse spherical gold nanometer crystals has the advantages of being simple in operation, good in repeatability, capable of obtaining the water-solubility biocompatibility monodisperse spherical gold nanometer crystals which are high in quality and can not be obtained in other existing methods.

Description

technical field [0001] The invention relates to a method for synthesizing water-soluble, biocompatible and monodisperse spherical gold nanocrystals of different sizes, belonging to the technical field of gold nanocrystal synthesis. Background technique [0002] Due to its unique physical and chemical properties, gold nanocrystals have broad application prospects in many fields such as nanoelectronics, nanophotonics, catalysis, sensors, biomarkers, and the construction of new materials with two-dimensional and three-dimensional structures. In recent years, they have received extensive attention as excellent scaffold materials in the development of novel chemical and biosensors. Firstly, gold nanocrystals have good chemical stability; secondly, gold nanocrystals have unique photoelectric properties; thirdly, gold nanocrystals have high specific surface area; in addition, these properties of gold nanocrystals can be easily changed by changing their size , morphology and the su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24
Inventor 夏海兵丁文超陶绪堂
Owner SHANDONG UNIV
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