Application of tromethamine in drugs for treating hyperuricemia and related disease

A technology for hyperuricemia and tromethamine, which is applied in the fields of urinary system diseases, bone diseases, and drug combinations, can solve the problems of strong irritation of tromethamine, many side effects, and thrombosis, and achieves the promotion of uric acid dissolution. and excretion effect, the effect of weakening the inhibitory effect

Inactive Publication Date: 2016-08-17
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug has many side effects, some of which are serious, and it is not the first choice for correcting metabolic acidosis.
In addition, trom

Method used

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  • Application of tromethamine in drugs for treating hyperuricemia and related disease
  • Application of tromethamine in drugs for treating hyperuricemia and related disease
  • Application of tromethamine in drugs for treating hyperuricemia and related disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 The solubility change of uric acid in different alkaline media

[0043] Prepare 1M sodium hydroxide (NaOH), tromethamine (Tris), sodium bicarbonate (NAHCO 3 ), N-ethylethylenediamine (NEEDA), disodium hydrogen phosphate (Na 2 HPO 4 ) and sodium acetate (NaAc) solution. Then dilute it sequentially in a plastic transparent test tube with a cover according to a 2-fold gradient to obtain alkaline solutions with different concentrations (1-700 mM), and the final volume of each test tube is 1 mL. Add a sufficient amount of uric acid (analytical pure) powder into alkaline solutions of different concentrations, shake continuously for more than 4 hours, and add uric acid powder (to make a saturated solution) in the middle to ensure that there is visible undissolved uric acid powder in the test tube before testing (precipitation). Centrifuge in a high-speed centrifuge at 10,000 rpm for 5 minutes before detection, take 200 μL of the supernatant and add it to a 96-wel...

Embodiment 2

[0045] Example 2 Solubility changes of uric acid in different near-neutral media

[0046] Prepare 1M urea, glucose, sodium chloride (NaCl), sodium sulfate (Na 2 SO 4 ), sodium nitrate (NaNO 3 ), potassium chloride (KCl), calcium chloride (CaCl 2 ), magnesium chloride (MgCl 2 ), magnesium sulfate (MgSO 4 ) and ammonium chloride (NH 4 Cl) solution. Then it was diluted successively in plastic transparent test tubes with lids according to a 2-fold gradient to obtain solutions of different concentrations (1-700 mM), and the final volume of each test tube was 1 mL. Add a sufficient amount of uric acid (analytical pure) powder to solutions of different concentrations, shake continuously for more than 4 hours, and replenish uric acid powder appropriately in the middle to ensure that there is visible undissolved uric acid powder (precipitation) in the test tube before the test. Centrifuge at 10,000rpm in a high-speed centrifuge for 5 minutes before detection, take 200 μL of the ...

Embodiment 3

[0048] Example 3 Solubility changes of uric acid in four kinds of amino acid media

[0049] 1M solutions of arginine, lysine, glycine and histidine were prepared respectively. Then it was diluted successively in plastic transparent test tubes with lids according to a 2-fold gradient to obtain solutions of different concentrations (1-700 mM), and the final volume of each test tube was 1 mL. Add a sufficient amount of uric acid (analytical pure) powder to solutions of different concentrations, shake continuously for more than 4 hours, and replenish uric acid powder appropriately in the middle to ensure that there is visible undissolved uric acid powder (precipitation) in the test tube before the test. Centrifuge in a high-speed centrifuge at 10,000 rpm for 5 minutes before detection, take 200 μL of the supernatant and add it to a 96-well plate that is transparent to ultraviolet light, use a microplate reader to detect the optical density at 292 nm, and calculate the uric acid co...

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Abstract

The invention discloses application of tromethamine in drugs for treating hyperuricemia and related disease. The tromethamine can serve as a drug in application of treating hyperuricemia, urinary system uric acid calculi and gout, an adult takes 1-7 g of the dose every day, and the medication method is intravenous drip. The tromethamine is used for promoting uric acid to dissolve and discharge, no inorganic ions exist because the tromethamine is organic amine alkali, the inhibiting effect of the inorganic ions can be avoided or weakened, the effect of the tromethamine for promoting uric acid to dissolve and discharge is better than that of sodium bicarbonate, and the tromethamine can be used for treating hyperuricemia, urinary system uric acid calculi and gout. Besides, the tromethamine is a foreign substance, an organic body cannot produce the tromethamine substance, and accordingly, the concentration of the tromethamine in the body is better to control compared with the sodium bicarbonate in the medication process.

Description

technical field [0001] The invention belongs to the field of new applications of tromethamine, in particular to the application of tromethamine as a drug for treating hyperuricemia and related diseases. Background technique [0002] Gout is a metabolic disease caused by long-term purine metabolism disorder and increased blood uric acid. It is an ancient disease and is more common in Europe and North America. Hyperuricemia is an important biochemical basis of gout, although the prevalence of gout is much lower than that of hyperuricemia. Since the 1950s, the economies of Japan, Taiwan and other regions have developed rapidly, and the prevalence of gout and hyperuricemia has gradually increased. After the 1980s in my country, the prevalence rate also showed a clear upward trend, and men were higher than women. For example, in 2006, an epidemiological survey in Shandong coastal areas showed that the prevalence of hyperuricemia in men was 18.32%, and that of gout was 1.94%. %. ...

Claims

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Application Information

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IPC IPC(8): A61K31/133A61P19/06A61P13/04
CPCA61K31/133
Inventor 段为钢高志毅殷华云宇
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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