5 results about "Phosphonomycin" patented technology

The utility model discloses a raw material particle mixing device, and particularly relates to the technical field of fosfomycin tromethamine production mixing, the raw material particle mixing device comprises a mixing cylinder, the top end of the mixing cylinder is fixedly provided with a fixing ring, the surface of the fixing ring is detachably provided with a sealing plate through a plurality of bolts, the sealing plate is provided with a driving motor, and the driving motor is connected with the fixing ring. A stirring shaft is arranged at the output end of the driving motor, a plurality of telescopic stirring blade structures are fixedly arranged on the outer wall of the stirring shaft, each telescopic stirring blade structure comprises an outer pipe, one end of each outer pipe is fixedly mounted on the outer wall of the stirring shaft, an inner rod is slidably arranged in each outer pipe, and a concave block is fixedly arranged at one end of each inner rod. According to the utility model, the mixing range of raw materials in the mixing barrel can be enlarged, so that the mixing effect is improved, the caked raw materials and attachments on the inner wall of the mixing barrel can be beaten, uniform mixing of particles is promoted, residues on the wall of the barrel can be vibrated off after discharging, and the use effect is improved.

This invention discloses a method for detecting genotoxic impurities in fosfomycin calcium. The method involves preparing a test solution and a reference solution using hydrochloric acid as a solvent, and then detecting the test solution and reference solution using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) to obtain the content of genotoxic impurities in fosfomycin calcium. The genotoxic impurities are: 1,2-epoxypropyl diethyl phosphate, (2-propenyl)-diethyl phosphate, allyl diethyl phosphate, and propyl diethyl phosphate. This invention develops an analytical method capable of simultaneously detecting four diethyl phosphonate genotoxic impurities in fosfomycin calcium. This method exhibits good specificity, injection precision, linear range, limit of quantitation, limit of detection, accuracy, repeatability, intermediate precision, and robustness. It can be used for the detection and monitoring of diethyl phosphonate impurities in fosfomycin calcium raw materials, ensuring product quality and improving the safety of clinical medication.

The utility model provides a reaction device for preparing fosfomycin tromethamine, and particularly relates to the technical field of pharmaceutical production, the reaction device comprises a tank body, a feed port and a discharge port are respectively arranged at the upper end and the lower end of the tank body, an interlayer is arranged outside the tank body, a plurality of partition plates are vertically arranged in the interlayer, and the partition plates divide the interlayer into a plurality of cavities; a first outlet and a second outlet are respectively formed in the lower sides of two adjacent cavities; a first inlet and a second inlet are respectively formed in the upper sides of the two cavities adjacent to the first outlet and the second outlet; in the anticlockwise direction of the first inlet, each cavity is provided with a plurality of first flow guide pipes at intervals, and every two spaced partition plates are connected through the corresponding first flow guide pipe; in the clockwise direction of the second inlet, each cavity is provided with a plurality of second flow guide pipes at intervals, and every two spaced partition plates are connected in a penetrating mode through the corresponding second flow guide pipes. According to the utility model, the heating efficiency can be improved, and the heating uniformity can be improved.

This invention discloses a lyophilized formulation of fosfomycin sodium for injection and its preparation method. The lyophilized formulation comprises fosfomycin sodium, L-histidine, trehalose dihydrate, glycine, and disodium edetate, wherein L-histidine serves as a buffer component, trehalose dihydrate serves as an amorphous matrix protectant, glycine serves as a crystalline framework agent, and disodium edetate serves as a metal ion chelating agent. The preparation method includes solution preparation, pH adjustment and fine filtration, pre-freezing and annealing, primary drying, secondary drying, and nitrogen sealing. This invention, through the synergistic combination of quaternary excipients, specifically solves multiple technical problems in the fosfomycin sodium system, such as epoxy hydrolysis degradation, difficulties in lyophilization due to high sodium content, and extreme hygroscopicity. The resulting lyophilized formulation exhibits intact appearance, rapid reconstitution, and good stability.

The invention relates to the technical field of biomedicine, and provides application of combination of bacteriophage and antibiotic in preparation of a drug-resistant bacterial infection drug, the bacteriophage is acinetobacter baumannii or mycobacterium tuberculosis bacteriophage, and the antibiotic comprises one or more of amikacin, fosfomycin and polymyxin B. The invention provides the application of the combination of the bacteriophage and the antibiotic in the aspect of preparing the drug-resistant bacterial infection drug, the synergistic interaction can be realized, the drug resistance is reduced, the bacteriocidal spectrum is expanded, and the support is provided for the early intervention, accurate effect generation and prognosis improvement of the drug-resistant bacterial infection.