Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same

A manufacturing method, composition technology, applied in the direction of drug combination, antibacterial drug, drug delivery, etc., to achieve high therapeutic efficacy, efficacy and quality increase effect

Inactive Publication Date: 2012-12-05
维克托历沃维奇·利莫诺夫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention is based on the use of a parenteral form of fosfomycin and finely divided nanostructured silica (ВНSiO 2 ) solves the problem of producing an antibacterial and traumatic pharmaceutical composition for external application, said fosfomycin and finely dispersed nanostructured silica with high therapeutic efficacy for the treatment of infectious and inflammatory diseases

Method used

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  • Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same
  • Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same
  • Pharmaceutical composition having antimicrobial and fast-healing activity for external administration, process for preparing same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Example 1. Manufacture of powdered compositions: Fosfomycin / BHSiO 2 .

[0029] Processing of fosfomycin and ВНSiO in weight ratios of 3:1, 1:1 and 1:3 in a circular rotary mill 2 mixture for 2 and 4 hours. Data on the particle size composition of the aqueous suspension (using a Micro-Sizer 201 laser particle size analyzer) and HPLC analysis of the antibiotic content (expressed as % of starting material) are presented in Table 1.

[0030] As can be seen from Table 1, the selected composition manufacturing conditions make the finely dispersed ВНSiO 2 The fraction of fractions (particle size less than 5 microns) is increased to a certain value (not less than 40% of the total weight) and chemical degradation of the antibiotic is avoided.

[0031] by ВНSiO 2 The particles have a measured fosfomycin adsorption of 20% to 25%.

[0032]

[0033] Table 1

[0034] Particle size composition and fosfomycin content of aqueous suspensions in different compositional vari...

example 2

[0037] Example 2. Determination of therapeutic efficacy of fosfomycin and pharmaceutical compositions.

[0038] Antibiotics / BHSiO have been studied mechanized for 2 hours with a weight ratio of 1:1 (i.e. (50% by mass): (50% by mass)) 2 The mixture consists of fosfomycin.

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PUM

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Abstract

This invention is related to pharmacology, medicine, veterinary science and pharmaceutical industry,in particular to the process for the production of original composite antimicrobial and vulnerary preparations for external administration having an increased therapeutic efficiency in the treatment of skin and soft tissues infections. The claimed pharmaceutical composition contains antibiotic fosfomycin and finely dispersed nanostructured silica dioxide as active agents. The claimed process for the production of the pharmaceutical composition consists in mixing fosfomycin substance with finely dispersed nanostructured silica dioxide, characterized in that the micture of said substances in the weight ratio (25-75% by weight) : (75-25% by weight) respectively is being exposed to mechanical treatment by impact and abrasive actions to increase the weight percentage of the finely dispersed fraction ( 5 micron) to at least 40%.

Description

technical field [0001] The invention belongs to antibacterial drug preparation and its manufacturing technology. It can be used in medicine and veterinary medicine as prophylaxis and medical maintenance of febrile infection of skin and soft tissue wounds, to accelerate wound healing in the postoperative period, and in the pharmaceutical industry for the manufacture of medicinal products. Background technique [0002] The antibiotic known under the international non-proprietary drug name fosfomycin has multiple antimicrobial effects and provides bactericidal action against many gram-positive and gram-negative microorganisms through its Intravenous parenteral form (mainly fosfomycin sodium salt) is successfully used in the treatment of skin, soft tissue, bone and joint infections [1, 2, 3, 4, 5]. [0003] Fosfomycin has been found to penetrate into phagocytes (neutrophils and macrophages), stimulate their phagocytic activity, and have a bactericidal effect on intracellularly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/665A61K9/14A61K9/51A61K47/04A61P31/04
CPCA61K9/143A61K31/665A61K9/0014A61P17/02A61P31/00A61P31/04
Inventor 维克托历沃维奇·利莫诺夫康斯坦丁瓦连京诺维奇·盖杜尔亚历山大瓦莱雷维奇·杜什金
Owner 维克托历沃维奇·利莫诺夫
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