The invention provides a synthesis method of a medical intermediate 3-oxocyclobutanecarboxylic acid. A target product 3-oxocyclobutanecarboxylic acid is obtained by adopting
acetone,
bromine and
malononitrile as raw materials, adopting
ethanol, DMF (
dimethyl formamide) and water as solvents, adopting
sodium iodide as an activating agent and
tetrabutylammonium bromide (TBAB) as a
phase transfer catalyst through three-step reaction. By measurement of H-
nuclear magnetic resonance, a
mass spectrum, the high-efficiency
gas chromatography and a
melting point, the synthesized final product is proved to be the 3-oxocyclobutanecarboxylic acid, the purity of 3-oxocyclobutanecarboxylic acid is 99 to 99.2 percent, and the yield of 3-oxocyclobutanecarboxylic acid is 52 to 68 percent. The synthesis method is simple in process
route, short in production period and low in synthesis cost; meanwhile, the application of highly toxic products such as
osmium tetroxide and
propadiene can be avoided, and the process is more moderate, more reliable and
safer; and the solvents such as the
ethanol, the DMF and the methylbenzene can be recycled in the reaction process, so that the emission and
processing costs of toxic
reagent can be reduced, the national
environmental protection can be achieved, and a good industrialized production prospect can be realized.