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Preparation method of phosphomycin calcium capsules

A technology of fosfomycin calcium and capsules, which is applied in the field of preparation of fosfomycin calcium capsules, which can solve the problems of difficult dissolution of capsules, achieve high-efficiency release, high safety performance, and solve the effects of toxic and side effects

Inactive Publication Date: 2018-12-18
安徽鼎旺医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The medicinal capsule material prepared in the present invention has good solubility, and can quickly dissolve into a harmless substance absorbed by the human body after oral administration. problem, which is beneficial to improve the bioavailability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of modified starch by sol-gel method:

[0042] Add 40g of starch to 30g of purified water at a temperature of 60-80°C, stir for 30-60min until evenly mixed to obtain a starch solution;

[0043] Add 10 g of polyethylene glycol solid to the starch solution, stir for 30-60 minutes, add sodium hydroxide solution to adjust the pH of the mixed solution A to 8-10, continue stirring for 30-60 minutes until the mixture is uniform, and obtain starch colloid;

[0044]Put the starch colloid in the refrigerator for 10-20 hours, take it out, add tert-butanol to replace the solution in a water bath at 50-60°C, repeat it several times, then filter it with suction, put the filter cake in an oven at 80-100°C After drying for 10-15 hours and grinding into powder, modified starch is obtained. Starch is used as a pharmaceutical excipient because it is an edible substance, has no harm to the human body, and has high safety performance. Compared with ordinary starch, modified star...

Embodiment 2

[0058] Preparation of modified starch by sol-gel method:

[0059] Add 50g of starch to 40g of purified water at a temperature of 60-80°C, stir for 30-60min until evenly mixed, and obtain a starch solution;

[0060] Add 20 g of polyethylene glycol solid to the starch solution, stir for 30-60 minutes, add sodium hydroxide solution to adjust the pH of the mixed solution A to 8-10, continue stirring for 30-60 minutes until the mixture is uniform, and obtain starch colloid;

[0061] Put the starch colloid in the refrigerator for 10-20 hours, take it out, add tert-butanol to replace the solution in a water bath at 50-60°C, repeat it several times, then filter it with suction, put the filter cake in an oven at 80-100°C After drying for 10-15 hours and grinding into powder, modified starch is obtained. Starch is used as a pharmaceutical excipient because it is an edible substance, has no harm to the human body, and has high safety performance. Compared with ordinary starch, modified s...

Embodiment 3

[0075] Preparation of modified starch by sol-gel method:

[0076] Add 45g of starch to 35g of purified water at a temperature of 60-80°C, stir for 30-60min until evenly mixed, and obtain a starch solution;

[0077] Add 15 g of polyethylene glycol solid to the starch solution, stir for 30-60 minutes, add sodium hydroxide solution to adjust the pH of the mixed solution A = 8-10, continue stirring for 30-60 minutes until the mixture is uniform, and obtain starch colloid;

[0078] Put the starch colloid in the refrigerator for 10-20 hours, take it out, add tert-butanol to replace the solution in a water bath at 50-60°C, repeat it several times, then filter it with suction, put the filter cake in an oven at 80-100°C After drying for 10-15 hours and grinding into powder, modified starch is obtained. Starch is used as a pharmaceutical excipient because it is an edible substance, has no harm to the human body, and has high safety performance. Compared with ordinary starch, modified st...

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PUM

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Abstract

The invention discloses a preparation method of phosphomycin calcium capsules. In a preparation process of the phosphomycin calcium capsules, the content of each component raw material is as follows in parts by weight: 30 to 35 parts of phosphomycin calcium, 10 to 20 parts of lactose, 15 to 20 parts of modified starch, 3 to 5 parts of an adhesive, 2 to 4 parts of a lubricant, 30 to 40 parts of purified water and 5 to 20 parts of a medical capsule material. The medical capsule material prepared by the invention has good dissolubility and can be rapidly dissolved into harmless substances absorbed by human bodies after being orally taken; after being disintegrated, a medicine is rapidly absorbed by the human bodies, and the bioavailability of the medicine is easy to improve; starch is used asa medical auxiliary material and is an edible substance so that the starch has no dangers to the human bodies and high safety; compared with common starch, modified starch has a larger specific surface area and the starch with the unit mass can absorb more medical active components; a pore channel of the starch has a porous structure and provides more attachment sites for an attachment object; the dosage of the starch can be saved, and the active components also can be efficiently adsorbed and rapidly dissolved out.

Description

technical field [0001] The invention belongs to the technical field of medicine and medicine production, and in particular relates to a preparation method of fosfomycin calcium capsules. Background technique [0002] Fosfomycin calcium antibiotics have a significant effect on the treatment of otitis media, sinusitis, urinary tract infection, intestinal infection, Helicobacter pylori infection and other diseases. [0003] Ordinary fosfomycin calcium contains many types and quantities of excipients, such as lubricants, adhesives, disintegrants, etc. are generally used. More and more studies have shown that the excipients themselves have toxic and side effects, which affect the safety of the drug. It has an impact, and the drugs prepared from traditional excipients have a longer time for the drug to be absorbed in the human body. [0004] Therefore, it is necessary to provide a method that can overcome the above disadvantages, select suitable auxiliary materials and preparatio...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K47/04A61K31/665A61P31/04A61P27/16A61P11/02A61P13/02A61P1/00
CPCA61K9/4816A61K9/485A61K9/4866A61K31/665A61P1/00A61P11/02A61P13/02A61P27/16A61P31/04
Inventor 杨会来方泽民
Owner 安徽鼎旺医药有限公司
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