A method for simultaneously detecting fosfomycin and its diols by ion chromatography

An ion chromatography and fosfomycin technology, applied in the field of chemical substance analysis and detection, can solve the problem of inability to distinguish fosfomycin and fosfomycin diol, inability to detect and affect fosfomycin and fosfomycin diol. Accuracy of fosfomycin, etc., to achieve the effect of low detection limit, high sensitivity and good reproducibility
CN112710773BActive Publication Date: 2021-10-08CHINESE RES ACAD OF ENVIRONMENTAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINESE RES ACAD OF ENVIRONMENTAL SCI
Publication Date
2021-10-08

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Abstract

The invention belongs to the technical field of chemical substance analysis and detection, and discloses a method for simultaneously detecting fosfomycin and its diols by using ion chromatography. The method that the present invention adopts ion chromatography to detect fosfomycin and its diols simultaneously comprises the following steps: (1) the selection of ion chromatography instrument and chromatographic test conditions: the chromatographic column is a low-capacity hydroxide system cathodic protection column, and the suppressor Adopt electrolytic membrane suppressor, eluent is NaOH or KOH solution; (2) draw fosfomycin standard curve with fosfomycin sodium as standard; (3) take fosfomycin trometamol EP impurity A as standard (4) test and obtain the peak area of ​​fosfomycin and its glycol in the sample, and obtain the corresponding concentration after substituting into the standard curve. The method of the invention has the advantages of good reproducibility, low detection limit, high sensitivity, simple operation, wide use of ion chromatographic equipment, etc., and can simultaneously test fosfomycin and its glycols.
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Description

technical field

[0001] The invention relates to the technical field of analysis and detection of chemical substances, in particular to a method for simultaneously detecting fosfomycin and its diols by using ion chromatography. Background technique

[0002] In recent years, multidrug-resistant bacteria, pan-drug-resistant bacteria, and even full-drug-resistant bacteria have emerged continuously, which has brought severe challenges to the diagnosis and treatment of clinical infectious diseases. Studies have confirmed that fosfomycin has good antibacterial activity against drug-resistant bacteria due to its unique antibacterial mechanism. Therefore, fosfomycin has received great attention in clinical anti-infection treatment. However, in different stages of fosfomycin production, different concentrations of fosfomycin wastewater will be produced. As an antibiotic, fosfomycin is discharged into natural water bodies, which will cause drug resistance of bacteria in the environment...

Claims

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