Graphene catheter composition, catheter preparation method and application

A technology of graphene and composition, which is applied in the field of biomedicine, can solve the problems that artificial nerve guides cannot achieve autologous nerve transplantation, and achieve the effects of easy quality control, simple preparation, and wide application

Inactive Publication Date: 2019-06-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art and overcoming the problems existing in existing nerve guides or other guides, such as the current artificial nerve guide c

Method used

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  • Graphene catheter composition, catheter preparation method and application
  • Graphene catheter composition, catheter preparation method and application
  • Graphene catheter composition, catheter preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The preparation method of the graphene catheter, the method specifically includes the following steps:

[0047] A. Mix the components in the graphene catheter composition in proportion to obtain a mixture;

[0048] B. Carry out 3D printing or electrospinning of the mixture obtained in step A to prepare a catheter;

[0049] C. The inside of the catheter is sprayed with a layer of bioadhesive material by 3D printing or electrospinning, and cross-linked and solidified to obtain the graphene catheter.

[0050] In the step A, the preparation of the mixture includes mixing the biodegradable material and graphene to prepare a suspension, or adding graphene to the molten biodegradable material and mixing.

[0051] The method also includes the steps of disinfecting and sterilizing the graphene catheter prepared in step C, and then packaging.

Embodiment 1

[0052] Example 1 Preparation of graphene catheter composition

[0053] Based on 100% of the total weight, the weight ratio of graphene (which is at least one of single-layer graphene, multilayer graphene, and graphene oxide) is 0.5%, 1%, 2%, 5%, and 10%, respectively. The weight ratios of biodegradable materials (PCL, PLA, PLGA, collagen, gelatin or any combination thereof) are respectively 99.5%, 99%, 98%, 95%, and 90%, and the mixing method includes: Use hot-melt biodegradable materials (the temperature is higher than the melting point temperature of the material, such as PLA temperature is higher than 80 degrees Celsius), or use organic solvents (such as dichloromethane, ethyl acetate) or water to dissolve the biodegradable materials (such as biodegradable materials) When the degradable material is PCL, PLA or PLGA, it is dissolved in an organic solvent, and when the biodegradable material is collagen or gelatin, it is dissolved in water), and then graphene is added and mixed...

Embodiment 2

[0054] Example 2 Preparation of graphene catheter

[0055] Electrospin the catheter material of Example 1 to prepare catheters, use conventional electrospinning technology to prepare various required catheters; or use 3D printing technology to print various catheters; or use catheter molds to prepare various required catheters Conduit, such as single-layer graphene or multilayer graphene PLA conduit, graphene oxide PLA conduit, single-layer graphene or multilayer graphene PCL conduit, graphene oxide PCL conduit, single-layer graphene or multilayer graphene PCLA conduit Graphene oxide, PCLA catheters, etc. can all be prepared by the method of this embodiment. Such as 3D printed and 1% graphene PCL nerve conduit (such as figure 1 Shown) has good nerve regeneration properties such as elastic modulus better than pure PCL printing (48.32 and 31.77MPa respectively).

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Abstract

The invention relates to a graphene catheter composition, a catheter preparation method and an application. The graphene catheter composition comprises the following components by the mass percentages: 90-99.5% of a biodegradable material, and 0.5-10% of graphene. The graphene catheter comprises a catheter and a biological adhesion substance layer, and the biological adhesion substance layer is arranged on the inner wall of the catheter; the catheter is prepared by the graphene catheter composition. The preparation method comprises that the graphene catheter composition is printed in 3D or electrospun to produce a catheter; the interior of the catheter is sprayed with a biological adhesion substance by 3D printing or electrospinning, and the catheter is crosslinked and solidified, so thatthe graphene catheter can be obtained. The catheter can promote regeneration, proliferation and differentiation of nerves, blood vessels and the like. In-vivo experiments show that the repair of animal peripheral nerves such as sciatic nerves is superior to that of autologous nerve transplantation, and practical and clinical value is achieved.

Description

Technical field [0001] The invention relates to the technical field of biomedicine, in particular to a graphene catheter composition, a catheter preparation method and application. Background technique [0002] Various biomedical catheters, including degradable and non-degradable catheters, such as polyethylene tubes have been used as nerve catheters to study nerve regeneration. Because the catheters are not degraded, after the nerve regeneration is completed, if the catheters are not treated, it may cause Tissue fibrosis, causing inflammation and other side effects, the clinical application effect is not very satisfactory. At present, various biodegradable materials have been developed to prepare various biomedical catheters, such as collagen, polylactic acid, etc. However, because these materials are used alone, there are also some problems such as strength, speed of nerve regeneration, and toxic side effects. Recently, it has been developed to carry out further research on th...

Claims

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Application Information

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IPC IPC(8): A61L27/28A61L27/44A61L27/50A61L27/54A61L27/58
Inventor 袁伟恩赵笑天程媛郭晓霜
Owner SHANGHAI JIAO TONG UNIV
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