Disclosed are non-
human animal models, and preferably,
rodent models, and more preferably, mouse models, of B-
cell Non-Hodgkin's
Lymphoma (NHL). In particular, the present invention provides animal models of
B cell NHL including,
B cell chronic lymphocytic leukemia /
lymphoma (B-CLL), Burkitt's
lymphoma (BL), Follicular-like
lymphoma (FLL) and Diffuse large B-
cell lymphoma (DLBCL), as well as various methods for producing these non-
human animal models. These animal models, as well as
cell lines produced from or derived from these models, are useful tools for a variety of methods, including, but not limited to, preclinical testing of
drug candidates, and particularly
drug candidates that are specific for
human proteins, and any research, development, pharmaceutical, or clinical purpose, including but not limited to, the identification, development, and / or testing of drugs (therapeutics, prophylactics, etc.), targets, markers, and / or research tools for use in the diagnosis of, study of, or treatment of any Non-Hodgkin's
Lymphoma, such as those described herein, or for any related condition.