Fluorescent probe for specifically distinguishing different thiol

A fluorescent probe and specific technology, which is applied in the field of fluorescent probes, can solve the problems of poor selectivity, few reports on fluorescent probes, inability to selectively distinguish thiophenols, etc., and achieve simple synthesis routes and simple operations , low cost effect
CN108358906AActive Publication Date: 2018-08-03CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2018-08-03

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Abstract

The invention relates to a fluorescent probe for specifically distinguishing different thiol and belongs to the field of fluorescent probes. A molecular structure of the fluorescent probe is as follows: a formula is shown in the description. A probe molecule has no fluorescent light; after the probe molecule responds with thiophenol, a solution produces blue light and red light; after the probe molecule responds with GSH (glutathione), the solution produces the blue light; after the probe molecule responds with Hcy / Cys, the solution produces the blue light and green light. The probe molecule provided by the invention can be used for distinguishing different types of the thiol and can be used for rapidly and quantitatively detecting different types of the thiol, and has important application value in the fields of biochemistry, environment monitoring and the like.
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Description

technical field

[0001] The invention relates to the preparation of a fluorescent probe for specifically distinguishing different thiols and its application in detecting biological thiols and thiophenols in cells, belonging to the field of fluorescent probes. Background technique

[0002] Thiol is the general term of biothiol and thiophenol, which is an important class of compounds in living organisms and chemical industry. Biothiols include cysteine ​​(Cys), homocysteine ​​(Hcy) and glutathione (GSH), which play important roles in living organisms. Cysteine ​​deficiency can lead to liver damage, growth retardation, skin lesions, hair loss and lethargy; high levels of homocysteine ​​in the blood can cause cardiovascular disease, mental illness and Alzheimer's disease; glutathione in biological The content in the body is the most abundant, maintaining cell function, maintaining cell homeostasis, intracellular signal transduction, foreign body metabolism and gene regulation. ...

Claims

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