Novel dosage formulation

a technology of dosage formulation and dosage, applied in the field of new dosage formulation, can solve the problems of practical insolubility and achieve the effect of sufficient availability of active compounds

Inactive Publication Date: 2007-03-29
AHMED HASHIM A +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022] The oral dosage forms of the invention are suitable for delivery to human patients and are designed to enable sufficient availability of the active compound at its site of action. Such formulations may overcome the disadvantage of practical insolublility in simulated intestinal fluid for these compounds.

Problems solved by technology

Such formulations may overcome the disadvantage of practical insolublility in simulated intestinal fluid for these compounds.

Method used

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Embodiment Construction

[0024] The following definitions of general terms used herein apply irrespective of whether the terms in question appear alone or in combination. It must be noted that, as used in the specification and the appended claims, the singular forms “a”, “an,” and “the” include plural forms unless the context clearly dictates otherwise.

[0025] The term “lower alkyl” denotes a straight- or branched-chain alkyl group containing from 1 to 7 carbon atoms. Nonlimiting examples of lower alkyl include methyl, ethyl, propyl, isopropyl, n-butyl, i-butyl, t-butyl, and the like.

[0026] The term “alkylene group” means a lower alkyl linker which is bound to a group at either end. Nonlimiting examples of alkylene groups include methylene, ethylene, propylene, and the like.

[0027] The term “lower alkoxy” denotes a alkyl group as defined above, which is attached through an oxygen atom. Nonlimiting examples of lower alkoxy groups include methoxy, ethoxy, propoxy, and the like.

[0028] The term “cycloalkyl” d...

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Abstract

The invention relates to a process for preparing a pharmaceutical tablet composition which comprises an active pharmaceutical ingredient of formula I wherein the definitions are described in claim 1, or pharmaceutically acceptable acid addition salts thereof and a water soluble poloxamer in which the compound of formula I and the water soluble poloxamer are processed by hot melt extrusion, and then the hot melt extrudate is mixed with other ingredients to form a tablet, that is optionally coated with a composition comprising an immediate release film coating system and purified water. The invention also relates to such pharmaceutical compositions and hot melt extrudates.

Description

PRIORITY TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 719,793, filed Sep. 23, 2005, which is hereby incorporated by reference in its entirety.BACKGROUND OF THE INVENTION [0002] Many substances obtained from modem drug discovery are problematic because of insufficient bioavailability. Such molecules often exhibit very low aqueous solubility and limited solubility in oils. Furthermore many substances exhibit significant food effects, i.e., when drugs and certain foods are taken at the same time they can interact in ways that diminish the effectiveness of the ingested drug or reduce the absorption of food nutrients. Additionally, vitamin and herbal supplements taken with prescribed medication can result in adverse reactions. [0003] Some examples of how foods and drugs can interact include: [0004] Food can speed up or slow down the action of a medication. [0005] Impaired absorption of vitamins and minerals in the body. [0006] ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/445A61K9/20
CPCA61K9/1641A61K9/1694A61K9/2031A61K9/2077C07D413/04A61K31/44A61K31/4427A61K31/445A61K31/455A61K9/2095A61P1/08A61P25/22A61P25/24A61P43/00A61K9/20
Inventor AHMED, HASHIM A.PAGE, SUSANNESHAH, NAVNIT HARGOVINDAS
Owner AHMED HASHIM A
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