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Temperature sensitive gel formulation for in situ vagina uses

An in-situ gel and gel preparation technology, which is applied in the direction of medical preparations of non-active ingredients, drug delivery, diseases, etc., can solve problems such as preparation methods of in-situ gel for vagina that have not been reported yet, and achieve enhanced treatment effect, improvement of compliance, effect of convenience of medication

Inactive Publication Date: 2005-03-16
SHANGHAI PHARMCO RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Comprehensive literature search, at present, there is no report about the temperature-sensitive vaginal in situ gel and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 prepares metronidazole vaginal gel in situ

[0016] Take 0.75% metronidazole, 0.02% benzalkonium bromide, 18% poloxamer 407, 10% poloxamer 188, add water to the full amount. The drug and benzalkonium bromide are dissolved in water, and the poloxamer is slowly added to the above solution under ice-bath and stirring conditions, and stored in low-temperature refrigeration until a clear solution is formed.

Embodiment 2

[0017] Example 2 Preparation of clindamycin vaginal gel in situ

[0018] Take 2% clindamycin, 0.02% benzalkonium chloride, 1% methylcellulose, 15% poloxamer 407, 15% poloxamer 188, add water to the full amount. Dissolve methylcellulose in water, and then prepare clindamycin vaginal in situ gel according to the process of Example 1.

Embodiment 3

[0019] Example 3 Nystatin vaginal in situ gel

[0020] Take 500,000 units of nystatin, 0.02% benzalkonium chloride, 0.2% carbomer 934P, 14% poloxamer 407, 18% poloxamer 188, and add water to the full amount. Disperse carbomer in water, adjust the pH to neutral with sodium hydroxide solution, add drugs and benzalkonium chloride, slowly add poloxamer to the above solution under ice bath and stirring conditions, store in low temperature refrigeration until po Loxamer dissolves completely.

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Abstract

The invention relates to a temperature sensitive gel formulation for in situ vagina uses which is prepared from effective dosage of medicament for treating female vagina infection and macromolecular findings through dissolving into cushioning solution or pure water, and charging poloxamer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a temperature-sensitive vaginal in-situ gel preparation and a preparation method thereof. Background technique [0002] Inflammation of the female reproductive system is the most common disease in gynecological clinics, among which vaginitis and cervicitis have a higher incidence rate in women of childbearing age. At present, the pharmaceutical formulations widely used clinically for the treatment of this disease are mostly suppositories, ointments and effervescent tablets. The above-mentioned dosage forms have disadvantages such as inconvenient administration, difficulty in releasing all the medicines, foreign body sensation in the vagina, easy damage to the vaginal mucosa, and easy contamination of clothing. [0003] The in situ gel drug delivery system is a novel dosage form that utilizes the properties of polymers sensitive to environmental factors to form a gel loca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61P15/02
Inventor 魏刚陆伟跃
Owner SHANGHAI PHARMCO RES
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