Bilobalide B raw material and preparation thereof

Abstract

The invention discloses a ginkgolide B raw material, which is characterized in that: the ginkgolide B raw material is made through the following method that: ginkgo leaves or ginkgo leaf extracts are taken and boiled in a hydrochloric acid solution; the boiled liquid undergoes organic extraction after filtration; when the obtained extract is condensed, 100 to 200-mesh silica gel is added in the extract to be mixed and dried; silica gel column chromatography is used to collect eluent rich in ginkgolide B, and the ginkgolide B raw material is obtained through crystallization; and the content of ginkgolide B in the ginkgolide B raw material is more than or equal to 90 percent. The ginkgolide B raw material made through adopting the method has high purity of ginkgolide B, simple preparation technological process, high transfer rate and low cost, and is suitable for industrial production.

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a ginkgolide B raw material and a preparation method thereof. technical background

[0002] Ginkgolide is currently one of the most powerful and specific platelet activating factor (PAF) receptor blockers. Ginkgolide B has the strongest blocking effect on PAF receptor among ginkgolides, and can be eliminated in a dose-dependent manner. The platelet aggregation caused by PAF prevents the formation of thrombus, but has no effect on the platelet aggregation induced by adenosine diphosphate, arachidonic acid, collagen and epinephrine. The latest pharmacological studies show that ginkgolide B has anti-allergic, anti-inflammatory, anti-shock effects, and also has protective effects on ischemic injury and rejection of organ transplantation.

[0003] The content of Ginkgolide B in Ginkgo biloba and Ginkgo leaf extract is very low. Currently, ginkgo prepar...

Images