Method for extracting bilobalide B from ginkgo leaf or ginkgo leaf extract

Abstract

The invention discloses a novel process for extracting bilobalide B from ginkgo leaf or ginkgo leaf extract through liquid-liquid extraction and refining, wherein the extraction solvent being n-butanol or other solvents having similar dissolving property and polarity. The obtained bilobalide B has a purity higher than 95% and a yield higher than 1%.

Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and relates to a new method for extracting active ingredients of medicine from ginkgo leaves or ginkgo leaf extracts. Background technique

[0002] Ginkgo biloba (Ginkgo hiloba L.) is a plant of the genus Ginkgo in the Ginkgo family. The ginkgo tree appeared 200 million years ago and was nearly extinct during the Ice Age. It only survived in my country and was called "living fossil" by Darwin. With the deepening of the research on Ginkgo biloba at home and abroad, it was found that ginkgolide B, the active ingredient in Ginkgo biloba, is a highly effective platelet activating factor antagonist, which has unique pharmacological effects and therapeutic value, which has aroused great interest in the pharmaceutical industry worldwide. big interest.

[0003] The sources of ginkgolide B can be divided into artificial cultivation, chemical synthesis and plant cell cult...