Azoxystrobin nanocapsule with shell-core structure and preparation method thereof

A technology of nano-microcapsules and azoxystrobin, which is applied in the processing of pesticide formulations and in the field of pesticides, which can solve problems such as dust pollution and achieve good encapsulation efficiency, regular shape, and uniform particle size

Active Publication Date: 2014-05-14
HENAN GOODDAYS BIOLOGY DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, it solves the problem of a large amount of organic solvents and dust pollution in the use of traditional pesticide formulations such as conventional EC and wettable powder. On the other hand, it improves the effective utilization rate of pesticides through controlled release, thereby improving the quality of pesticide preparations and reducing Loss, pollution and loss to the environment, to achieve sustainable development of pesticide formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh 5 grams of azoxystrobin original drug and encapsulation material chitosan-polylactic acid graft copolymer respectively and dissolve in 100 ml of dichloromethane, ultrasonically dissolve; mix according to 1:4 mass ratio to form an oil phase. The PVA is weighed and dissolved in 100 milliliters of water, and ultrasonically dissolved to prepare an aqueous phase containing 0.25-2% by weight of PVA. Then mix the oil phase and the water phase according to the volume ratio of 1:10, emulsify with high speed shear at 5000rpm for 5min, then remove the organic solvent by rotary evaporation, centrifuge at room temperature for 10min at 9000rpm, and the centrifuge in the lower layer is the shell-core structure azoxystrobin nanoparticle bag.

[0038] The determination results of azoxystrobin nanocapsules with shell-core structure formed under different PVA mass concentration conditions are shown in Table 1.

[0039] Table 1 The basic performance measurement results of azoxystrob...

Embodiment 2

[0044] Weigh 5 grams of azoxystrobin original drug and encapsulation material chitosan-polylactic acid graft copolymer respectively and dissolve in 100 ml of dichloromethane, ultrasonically dissolve; mix according to 1:4 mass ratio to form an oil phase. An appropriate amount of PVA was weighed and dissolved in 100 milliliters of water, and ultrasonically dissolved to prepare an aqueous phase containing 1% of the mass concentration of PVA. Then mix the oil phase and the water phase according to the volume ratio of 1:20-1:2, emulsify with high speed shear at 5000rpm for 5min, then remove the organic solvent by rotary evaporation, centrifuge at 9000rpm at room temperature for 10min, and the centrifuged substance in the lower layer is the shell-nucleus structure Azillabacterium Ester nanocapsules.

[0045] Table 2 shows the determination results of the shell-core structured azoxystrobin nanocapsules formed under different oil-water phase volume ratios.

[0046] Table 2 The basic ...

Embodiment 3

[0051] Weigh 5 grams of the azoxystrobin original drug and the encapsulation material chitosan-polylactic acid graft copolymer and dissolve them in 100 milliliters of dichloromethane, and dissolve them by ultrasonic; Mix to form an oil phase. An appropriate amount of PVA was weighed and dissolved in 100 milliliters of water, and ultrasonically dissolved to prepare an aqueous phase containing 1% of the mass concentration of PVA. Then mix the oil phase and the water phase according to the volume ratio of 1:10, emulsify at 5000rpm high-speed shearing for 5min, then remove the organic solvent by rotary evaporation, centrifuge at 9000rpm at room temperature for 10min, the lower centrifuge is the shell-core structure azoxystrobin nanocapsules .

[0052] Table 3 shows the determination results of azoxystrobin nanocapsules with a shell-core structure formed under different drug capsule mass ratios.

[0053] Table 3 The basic performance measurement results of azoxystrobin microcapsu...

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PUM

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Abstract

The invention relates to an azoxystrobin nanocapsule with a shell-core structure and a preparation method thereof. The azoxystrobin nanocapsule is prepared from a pesticide active ingredient, namely, azoxystrobin and a chitosan-polylactic acid graft copolymer as a packaging material; the weight ratio of azoxystrobin to chitosan-polylactic acid graft copolymer is (20:1) to (1:2); azoxystrobin is enveloped by a carrier to form the capsule with the shell-core structure; the particle size of the capsule is 280nm to 4.5 microns; the encapsulation efficiency of the capsule on the pesticide active ingredient azoxystrobin is over 70%, the drug-loading capacity is over 10%, the accumulated release rate within 400 hours can be up to over 80%, a plurality of fungal diseases on vegetables, fruit trees and grapes can be effectively prevented and controlled, and azoxystrobin nanocapsule has an important application value.

Description

technical field [0001] The invention relates to the field of pesticides, in particular to the technical field of processing pesticide formulations, in particular to azoxystrobin nanocapsules with a shell-core structure and a preparation method thereof. technical background [0002] With the improvement of global ecological environment and health awareness, the development of pesticide formulations is developing in the direction of high efficiency, low toxicity and low residue. In the current situation where the creation of new pesticide compounds is becoming more and more difficult, improving the performance of pesticides and giving full play to the biological activity and efficacy of active ingredients through advanced formulation processing methods has become an effective way to improve the effectiveness of pesticide control, reduce residual pollution, and save pesticide application costs. important way. [0003] In recent years, microencapsulation technology using biodeg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N43/54A01P3/00B01J13/14
Inventor 黄啟良曹立冬周训卿李凤敏
Owner HENAN GOODDAYS BIOLOGY DEV CO LTD
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