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Controlled release microparticles of Nano medication of curcumin, and preparation method

A technology of nano-drugs and slow-release particles, which is applied in the field of biomedical materials, can solve problems such as insolubility in water, and achieve the effects of high particle yield, improved properties, and long action time

Inactive Publication Date: 2007-05-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to propose a kind of preparation method based on the curcumin nano medicine system of emulsion-solvent diffusion theory, aim at the defect that curcumin is insoluble in water and easy to decompose, by wrapping curcumin in degradable polymer (polylactic acid, polylactic acid, Polylactic acid-glycolic acid copolymer) to make nanoparticles, thereby improving the hydrophobic properties of curcumin, prolonging the residence and action time of curcumin in the body, improving the bioavailability of curcumin, enhancing the targeting effect of drugs, and then providing Various research and clinical applications of curcumin lay the foundation

Method used

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  • Controlled release microparticles of Nano medication of curcumin, and preparation method
  • Controlled release microparticles of Nano medication of curcumin, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The ethanol solution containing 0.5 mg / ml of curcumin and the acetone solution containing 2.5 mg / ml of polylactic acid are mixed uniformly in a volume ratio of 3:2, and then the mixed solution is slowly added dropwise through a constant flow pump In 30 ml of 0.5% gelatin aqueous solution, after the dripping is completed, add the formed emulsion slowly to 50 ml of 0.167% gelatin aqueous solution through a constant flow pump again, keep high-speed stirring during the dripping, and maintain stirring for 4 hours after the dripping is completed Then take it out for low-temperature high-speed centrifugation (12,000 rpm), collect the concentrated solid nanoparticle-containing suspension emulsion, and finally freeze-dry the concentrated solid nanoparticle-containing suspension emulsion to obtain polylactic acid-loaded curcumin nanoparticles.

[0024] Laser particle size analysis shows that the obtained nanoparticles have a normal distribution with an effective diameter of 167 nm, a...

Embodiment 2

[0026]The ethanol solution containing 0.5 mg / ml of curcumin and the propylene carbonate solution containing 2.5 mg / ml of polylactic acid were mixed uniformly in a volume ratio of 3:2, and then the mixed solution was slowly mixed through a constant flow pump Add 30 ml of 1% gelatin aqueous solution dropwise. After the addition is complete, add the formed emulsion slowly to 50 ml of 0.3% gelatin aqueous solution through a constant flow pump again. Keep stirring at high speed during the dropping, and maintain it after the dropping. Stir for 2 hours, then take out the sample and put it in a dialysis bag for dialysis in deionized water overnight. After dialysis, take the sample out of the bag for low-temperature high-speed centrifugation (12,000 rpm), collect the concentrated solid nanoparticle suspension emulsion, and finally concentrate The suspoemulsion is freeze-dried to obtain polylactic acid-loaded curcumin nanoparticles.

[0027] Laser particle size analysis shows that the obtai...

Embodiment 3

[0029] The ethanol solution containing 1 mg / ml of curcumin and the acetone solution containing 5 mg / ml of polylactic acid are mixed uniformly in a volume ratio of 3:4.5, and then the mixed solution is slowly added dropwise through a constant flow pump In 30 ml of 0.5% gelatin aqueous solution, after the dripping is completed, the formed emulsion is slowly added dropwise to 50 ml of 0.167% gelatin aqueous solution through a constant flow pump again, maintaining high-speed stirring during the dripping, and maintaining stirring for 6 hours after the dripping is completed , Then take out the sample for low-temperature high-speed centrifugation (12,000 rpm), collect the concentrated solid nanoparticle suspension emulsion, and finally freeze-dry the concentrated suspension emulsion to obtain polylactic acid-loaded curcumin nanoparticles.

[0030] Laser particle size analysis shows that the obtained nanoparticles have a normal distribution with an effective diameter of 212 nm, and the po...

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Abstract

A slowly-releasing nano-particle of curcumin is prepared from the nano-particle of curcumin and the degradable polymer chosen from polylactic acid and the polylactic acid-hydroxyacetic acid copolymer by emulsion-solvent diffusion technique. It has high water dispersity and long releasing time (more than 2 weeks).

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to curcumin nano-medicine sustained-release particles and a preparation method thereof. Background technique [0002] Curcumin (Curcumin) [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a kind of β-diketone extracted from the ginger family turmeric Phenolic compounds. For centuries, curcumin has been used as a food spice, and it is also one of the important medicinal materials in Ayurvedic medicine. In addition to being used as pigments, fragrances, dyes, and cosmetics, curcumin also has a wide range of pharmacological effects. For example, curcumin can lower blood lipids, resist platelets and scavenge oxygen free radicals. It can improve the phagocytic power of the reticulum system and regulate the body's immunity Among them, the anti-tumor effect is one of the main activities of curcumin, and it has been listed as the third-generation cancer chemopreventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/12A61K47/34A61P35/00
Inventor 刘杰王一帆张胜民
Owner HUAZHONG UNIV OF SCI & TECH
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