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Ferulic acid and ferulic acid derivative anti-phytoviral agents

An anti-plant virus agent and derivative technology, applied in the field of pesticides, can solve the problems of environmental risks, difficult quality control, poor control effect, etc., and achieve the effects of low toxicity, good environmental compatibility, and extremely toxic effects

Active Publication Date: 2011-06-15
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many practical varieties of these existing anti-plant virus agents, and the control effect is poor, generally lower than 60%. Quality control is relatively difficult, and there is a certain environmental risk in long-term use.

Method used

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  • Ferulic acid and ferulic acid derivative anti-phytoviral agents
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  • Ferulic acid and ferulic acid derivative anti-phytoviral agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the chemical structural formula and physical constant of ferulic acid and derivative thereof, see table 1:

[0018] Table 1. Chemical structural formulas and physical constants of some ferulic acid and its derivatives

[0019]

[0020]

[0021]

[0022]

[0023]

Embodiment 2

[0024] Embodiment 2: the synthesis of trans-ferulic acid (1)

[0025] In a 50mL round bottom flask, add vanillin (10g, 0.065mol), malonic acid (7.5g, 0.07mol), toluene (15mL), pyridine and aniline in sequence, and react at 85-95°C for 2 hours. A 25% aqueous solution of potassium carbonate (35 mL) was added, followed by stirring. The aqueous layer was separated, and the pH was adjusted with concentrated hydrochloric acid. A large amount of solids were precipitated, filtered, washed with water, and dried to obtain trans-ferulic acid (11.6 g, 92%) in pale yellow needle crystals, mp 172-173°C.

Embodiment 3

[0026] Embodiment 3: the synthesis of target compound 20

[0027] In a 100mL round bottom flask, add 0.5g of trans-ferulic acid, 30mL of absolute ethanol, 0.1g of 10% Pd-C catalyst, blow hydrogen into it by a hydrogen balloon at room temperature for 6 hours, remove the Pd-C catalyst by filtration, and precipitate White solid 0.48g, yield 96%, mp 91-92°C.

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PUM

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Abstract

The invention relates to a ferulic acid shown in a general formula (I) and the application of derivatives thereof to pesticides. When used as novel anti-phytoviral agents, the derivatives can well inhibit tobacco mosaic viruses, pepper viruses, tomato viruses, sweet potato viruses, potato viruses, melon viruses, maize dwarf mosaic viruses and the like, and effectively prevent and control the virus diseases of various crops such as tobacco, peppers, tomatoes, melons, grains, vegetables, beans and the like, and are particularly suitable for preventing and controlling tobacco mosaic. Meanings of each group are shown in specifications.

Description

technical field [0001] The present invention relates to a class of novel anti-plant virus agents and their applications, in particular to ferulic acid and its derivatives as anti-plant virus agents, and the interaction composition of ferulic acid and its derivatives and active components with anti-plant virus as anti-plant virus agents. Plant virus agents and their application in preventing and treating plant virus diseases belong to the technical field of pesticides. Background technique [0002] Ferulic acid (FA), chemical name 4-hydroxy-3-methoxyphenylacrylic acid) is a ubiquitous phenolic acid that cross-links with polysaccharides and lignin in plant cell walls to form part of the cell wall , is one of the active ingredients of traditional Chinese medicines such as Ferulicum, Angelica, Chuanxiong, Cimicifuga, etc. It has been widely used in medicine, health care products, cosmetic raw materials and food additives because of its strong antioxidant activity and antiseptic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N43/90A01N43/60A01N43/32A01N43/30A01N43/16A01N37/48A01N37/38A01N35/02A01P1/00
CPCC07C57/44A01N37/38C07C59/64C07C59/48A01N43/30A01N47/44A01N37/40A01N43/32A01N43/60A01N43/40A01N37/10A01N43/16A01N43/36A01N35/02A01N43/90A01N37/44
Inventor 汪清民王开亮王兹稳
Owner NANKAI UNIV
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