Conjugate of indocyanine green and multi-arm polyethylene glycol or pharmaceutically acceptable salt thereof as well as preparation method and application of conjugate

By coupling ICG with multi-arm polyethylene glycol to form ICG-mArmPEG, the problems of short half-life and lack of targeting of ICG are solved, and higher tumor targeting and more accurate tumor imaging and diagnostic effects are achieved.

CN119823371AActive Publication Date: 2025-04-15NANJING YUNYING BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510028906.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-07
Publication Date
2025-04-15
Estimated Expiration
2045-01-07

AI Technical Summary

Technical Problem

The short half-life of ICG in the prior art and lack of tumor targeting limit its application in tumor resection.

Method used

A conjugate of indocyanine green and multi-arm polyethylene glycol (ICG-mArmPEG) was developed to couple ICG with multi-arm polyethylene glycol derivatives through an amidation reaction to form a drug that improves tumor targeting and prolongs the half-life.

Benefits of technology

This conjugate significantly reduces its binding ability to serum proteins, improves tumor targeting, and can accumulate and retention in tumor tissues, thereby achieving more accurate tumor localization and diagnosis.

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Abstract

The invention relates to the technical field of tumor fluorescence contrast agents, and particularly provides a conjugate of indocyanine green and multi-arm polyethylene glycol or pharmaceutically acceptable salt of the conjugate and a preparation method and application of the conjugate, the conjugate has the structural formula shown in the formula (I), the binding capacity of the conjugate and serum protein is remarkably reduced, and the conjugate can be applied to tumor fluorescence contrast agents. According to the present invention, the tumor targeting property is significantly improved, and the tumor is accumulated and detained in the tumor tissue, such that the targeted treatment or the high-resolution imaging is achieved so as to achieve the accurate tumor positioning and diagnosis, the high application value is provided, and the new method is developed for the tumor imaging and the treatment.
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