Experimental method for animal model depression degree evaluation based on metabonomics
A technology of metabolomics and animal models, applied in the experimental field of evaluating the degree of depression in animal models based on metabolomics, can solve problems such as complex preparation, many uncontrollable factors, and strong subjectivity of animals
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[0052] The present invention will be further described below in conjunction with specific embodiments.
[0053] An experimental method for evaluating the degree of depression in an animal model based on metabolomics, including the following steps:
[0054] S1 model construction and evaluation: The experimental animals were divided into a control group, a chronic mild unpredictable mild stress (CUMS) model group, and a paroxetine hydrochloride antidepressant positive administration group. Three groups were treated for long-term stress modeling. In the process of modeling, conduct behavioral experiments to evaluate model construction;
[0055] S2 Sample collection and processing: After all animals have undergone the behavioral experiment described in step S1, the three groups of animals are respectively subjected to pre-processing of their plasma samples and small molecule metabolites in the brain tissue by using methanol to precipitate proteins. , And finally collect plasma, hippocam...
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