Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Extraction process of tanshin general phenolic acid and its prepn and use

A technology of salvianolic acid and its extraction method, which is applied in the application field of salvianolic acid and its preparation in the pharmaceutical field, and can solve the problems of low content of salvianolic acid compounds, low regeneration utilization rate of resin, discount of pharmacological activity, etc. , to achieve the effect of less impurities, low cost and guaranteed quality

Inactive Publication Date: 2002-12-11
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
View PDF1 Cites 116 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method is because the water extract of Salvia miltiorrhiza is used on the resin column, and there are many impurities, the regeneration utilization rate of the resin is low, and the content of the obtained salvianolic acid compounds is also low.
In terms of preparations, because salvianolic acid compounds are unstable and easily decompose and deteriorate during preparation and storage, the ingredients contained in various Danshen injections and Danshen powder injections currently used in clinical practice are mainly Danshensu with weak activity and original Catechin aldehyde, and other highly active salvianolic acid components, such as salvianolic acid B, are decomposed and deteriorated, leaving little, and the pharmacological activity is greatly reduced

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Extraction of total salvianolic acid from the traditional Chinese medicine Salvia miltiorrhiza

[0026] 5kg of Salvia miltiorrhiza was crushed into a coarse powder, added with deionized water and heated at 100°C for three times of extraction. Add 30L water for the first time and heat for 1 hour; add 15L water for the second and third times and heat for 1 / 2 hour respectively. The extract was concentrated under reduced pressure at 60°C to 5 L, and after cooling, 14 L of 95% ethanol was added, allowed to stand overnight, and filtered. The filtrate decompression reclaims ethanol, and the gained concentrated solution passes through RA type macroporous adsorption resin (production of No. 7 Factory of Beijing Chemical Industry, takes styrene, stilbene as main body, dry resin amount 2kg), washes with deionized water until the effluent has no α-naphthalene For phenol reaction, continue to elute with 50% ethanol until the eluent is added with ferric trichloride potassi...

Embodiment 2

[0031] Example 2 Extraction of total salvianolic acid from the traditional Chinese medicine Salvia miltiorrhiza

[0032]5 kg of Salvia miltiorrhiza was crushed into a coarse powder, added with deionized water and extracted by heating at 70°C for 4 times. Add 30L of water for the first time, and then add 15L of water each time. The heating time for the first time is 1.2 hours, the time for the second extraction is 1 hour, and the time for the third and fourth extraction is 0.8 hours. The extract was concentrated under reduced pressure at 30°C to 5L, after cooling, 14L of 70% ethanol was added, allowed to stand overnight, and filtered. The filtrate decompression reclaims ethanol, and the gained concentrated solution passes through RA type macroporous adsorption resin (production of No. 7 Factory of Beijing Chemical Industry, takes styrene, stilbene as main body, dry resin amount 2kg), washes with deionized water until the effluent has no α-naphthalene For phenol reaction, conti...

Embodiment 3

[0033] Example 3 Extraction of total salvianolic acid from the traditional Chinese medicine Salvia miltiorrhiza

[0034] 5kg of Salvia miltiorrhiza was crushed into a coarse powder, added with deionized water and extracted by heating at 80°C for 4 times. Add 30L of water for the first time and heat for 1 hour; add 15L of water for the second, third and fourth times and heat for 1 / 2 hour respectively. The extract was concentrated under reduced pressure at 50°C to 5L, after cooling, 14L of 80% ethanol was added, allowed to stand overnight, and filtered. The filtrate decompression reclaims ethanol, and the gained concentrated solution passes through RA type macroporous adsorption resin (production of No. 7 Factory of Beijing Chemical Industry, takes styrene, stilbene as main body, dry resin amount 2kg), washes with deionized water until the effluent has no α-naphthalene For phenol reaction, continue to elute with 70% ethanol until the eluent is added with ferric trichloride pota...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to extraction process of total tanshin phenolic acid, the preparation process and application of its preparation. The total tanshin phenolic acid and its preparation mayuse in preparing medicine for preventing and treating cardiac and cerebral vascular diseases, senile dementia and hypomnesia caused by cerebral ischemia. The total tanshin phonelic acid prepared based on the process of the present invention has rich active components of tanshin and obvious pharmacological effect, stable performance and les stoxicity and is safety and reliable.

Description

technical field [0001] The present invention relates to a process for extracting salvia miltiorrhiza from the traditional Chinese medicine Salvia miltiorrhiza and a preparation method thereof, and the application of the salvianolic acid obtained by the method of the present invention and its preparation in the field of pharmacy, especially in the preparation of Cardiovascular and cerebrovascular diseases, senile dementia, and the application of drugs for the treatment of learning and memory dysfunction caused by cerebral ischemia. Background technique [0002] Salvia miltiorrhiza and its various preparations are traditional Chinese medicines commonly used in clinical treatment of cardiovascular and cerebrovascular diseases. Since the 1980s, we have systematically studied the water-soluble components of Salvia miltiorrhiza and its genus, and obtained salvianolic acids A(1), B(2), C(3), D(4), E(5), F (8), G(9), H(11)I(12), J(13), rosmarinic acid(6), shikonic acid(7), iso-salv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/14A61K31/192A61P9/10A61P25/28C07C51/47C07C51/48C07C59/52C07D307/04
Inventor 黎莲娘张均田陶忠华何丽一李保明杜冠华屈志炜
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com