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Agriophyllum squarrosum total flavonoid extract, and preparation method and application thereof

A technology for total flavonoids and extracts, which is applied in the field of total flavonoids extract of Saponin and its preparation, can solve problems such as unseen preparation technology research, and achieve the effect of economical preparation technology

Inactive Publication Date: 2014-02-26
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Throughout the literature reports at home and abroad, there is no research on the preparation process of the dry aerial part of the total flavonoids extract of Agriophyllum squarrosum (L.) Moq. See the research on the development of drugs for the treatment of diabetes by using the total flavonoids extract of Sapona

Method used

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  • Agriophyllum squarrosum total flavonoid extract, and preparation method and application thereof
  • Agriophyllum squarrosum total flavonoid extract, and preparation method and application thereof
  • Agriophyllum squarrosum total flavonoid extract, and preparation method and application thereof

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Effect test

Embodiment 1

[0025] The preparation of the total flavonoids extract of embodiment 1 saponin (one)

[0026] Dry the above-ground part of 2 kg of crushed Agriophyllum squarrosum (L.) Moq., add 70% ethanol to soak for 5 hours according to the ratio of medicinal material: ethanol solution of 1:10, and then extract by heating and refluxing for 3 times, each extraction time 3h, 2h, 2h respectively. Combine the three extracts, filter, recover the solvent, and concentrate to a relative density of 1.00-1.20. The concentrated solution was extracted three times with petroleum ether and n-butanol respectively, and extracted according to the ratio of concentrated solution:solvent 1:1. The 3 n-butanol extracts were combined and concentrated to obtain 61.3 g of n-butanol extract. The n-butanol extract was dissolved in 1.5L of distilled water, filtered, and the filtrate passed through the AB-8 macroporous resin column with a resin volume of 300ml at a flow rate of 1ml / min, and was repeatedly adsorbed 3 ...

Embodiment 2

[0027] The preparation of embodiment two saponin total flavonoids extract (two)

[0028] Dry the above-ground part of 2 kg of crushed Agriophyllum squarrosum (L.) Moq., add 50% ethanol to soak for 5 hours according to the ratio of medicinal material: ethanol solution of 1:15, and then heat and reflux for extraction 3 times, each extraction time 3h, 2h, 2h respectively. Combine the three extracts, filter, recover the solvent, and concentrate to a relative density of 1.00-1.20. The concentrated solution was extracted three times with petroleum ether and n-butanol respectively, and extracted according to the ratio of concentrated solution:solvent 1:1. The 3 n-butanol extracts were combined and concentrated to obtain 65.3 g of n-butanol extract. The n-butanol extract was dissolved in 1.5L of distilled water, filtered, and the filtrate passed through the AB-8 macroporous resin column with a resin volume of 300ml at a flow rate of 1ml / min, and was repeatedly adsorbed 3 times. Use...

Embodiment 3

[0029] The preparation of the total flavonoids extract of embodiment Sansapon (three)

[0030]Dry the aboveground part of 2 kg of crushed Agriophyllum squarrosum (L.) Moq., add 95% ethanol to soak for 5 hours according to the ratio of medicinal material: ethanol solution of 1:10, and then heat and reflux for extraction 3 times, each extraction time 3h, 2h, 2h respectively. Combine the three extracts, filter, recover the solvent, and concentrate to a relative density of 1.00-1.20. The concentrated solution was extracted three times with petroleum ether and n-butanol respectively, and extracted according to the ratio of concentrated solution:solvent 1:1. The 3 n-butanol extracts were combined and concentrated to obtain 56.5 g of n-butanol extract. The n-butanol extract was dissolved in 1.5L of distilled water, filtered, and the filtrate passed through the AB-8 macroporous resin column with a resin volume of 300ml at a flow rate of 1ml / min, and was repeatedly adsorbed 3 times. ...

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Abstract

The invention belongs to the field of pharmacy of traditional Chinese medicines and natural medicines, relates to a production technology of an effective part extract of agriophyllum squarrosum total flavonoids, and use of the effective part extract of agriophyllum squarrosum total flavonoids in the field of pharmacy, and provides a production technology of an effective part extract of agriophyllum squarrosum total flavonoids capable of ensuring the curative effect of a medicament. The agriophyllum squarrosum total flavonoid extract disclosed by the invention is the effective part extract of total flavonoids, which is prepared from the dry over-ground parts of plant agriophyllum squarrosum of chenopodiaceae agriophyllum in China by separation and purification. According to the effective part extract of the agriophyllum squarrosum total flavonoids disclosed by the invention, the total flavonoid content exceeds 50% (ultraviolet method); the content of isorhamnetin-3-O-rutinoside is 5-10% (high efficiency liquid chromatography). The preparation method disclosed by the invention is economical in technology, simple and convenient, and applicable to industrial production. The effective part extract of the total flavonoids has a pharmacological effect of reducing blood sugar, can be prepared into the dosage forms, such as capsules, tablets, granules and oral liquid, and compound preparations thereof, and can be applied to treatment of diabetes mellitus.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and relates to an extract of total flavonoids of saponin and its preparation method and application. Background technique [0002] Diabetes mellitus (DM) is an endocrine and metabolic common and frequently-occurring disease characterized by high blood sugar and multiple complications caused by absolute or relative insulin deficiency. A common lifelong chronic disease that threatens human health. At present, the prevalence rate of diabetes in China is 3.21%, and it shows an increasing trend, and the prevalence rate in big cities has reached 5% to 6%. The number of diabetic patients in my country has reached about 40 million, accounting for one-fifth of the total number of diabetics in the world, and more than 1.2 million new diabetic patients are added every year. my country has become the "hardest-hit area" of diabetes, the second largest country in the ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/10A61K31/7048
Inventor 李玉山回业乾李英华曲俊业刘铮赵宇姣
Owner SHENYANG PHARMA UNIVERSITY
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