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Pervone vincamine injection and preparation process thereof

A vincamine injection, vincamine technology, applied in medical preparations containing active ingredients, drug delivery, cardiovascular system diseases, etc., to achieve the effect of unique dosage form, convenient use, and easy industrial production

Inactive Publication Date: 2013-06-26
李荣立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing vincamine preparations are tablets and capsules. Although the existing tablets and capsules are convenient for administration, they need to obtain high blood drug concentration rapidly in many cases, and often need intravenous administration, especially for some patients due to various reasons. Patients who cannot swallow or have gastrointestinal dysfunction and cannot take oral administration, more need to use injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take by weighing vincamine 10g, lactic acid 1.0g, be placed in preparation container, add the water for injection of 2 / 3 preparation amount, stir and make vincamine dissolve completely, add the antioxidant sodium sulfite 2g that weighs again, (freeze-dried powder injection Need to add appropriate amount of proppant) and stir to make it completely dissolved, add water for injection to 2000ml full amount, adjust pH to 2.0-5.0 with citric acid, stir for about 30 minutes, add medicinal activated carbon for adsorption for 15-20 minutes, use medicinal The amount of carbon is about 0.03%, and after filtration, aseptic filling can be used to obtain the solution for injection; if the above solution for injection is freeze-dried, vacuum-capped, taken out, and the aluminum-pressed cap is labeled, the freeze-dried product can be obtained.

Embodiment 2

[0033] Take by weighing vincamine 10g, lactic acid 1.0g, sodium chloride 18g, place in preparation container, add the water for injection of 2 / 3 preparation amount, stir and make vincamine dissolve completely, then add the antioxidant sodium sulfite 2g weighed, Stir to dissolve it completely, add water for injection to 2000ml full amount, adjust pH to 2.0-5.0 with citric acid, stir for about 30 minutes, add medicinal activated carbon for adsorption for 15-20 minutes, the amount of medicinal carbon used is about 0.03% , filtered, and then sterilized and filtered with a 0.45 μm microporous membrane, dispensed into infusion bottles according to the predetermined dose, and sterilized at 115°C for 30 minutes.

Embodiment 3

[0035]Take by weighing vincamine 10g, acetic acid 1.0g, be placed in preparation container, add the water for injection of 2 / 3 preparation amount, stir and make vincamine dissolve completely, add the antioxidant sodium sulfite 2g that weighs again, (freeze-dried powder injection Need to add appropriate amount of proppant) and stir to make it completely dissolved, add water for injection to 2000ml full amount, adjust pH to 2.0-5.0 with tartaric acid, stir for about 30 minutes, add medicinal activated carbon for adsorption for 15-20 minutes, the amount of medicinal carbon used The amount is about 0.03%, and after filtration, aseptic filling can be used to obtain the solution for injection; if the above solution for injection is freeze-dried, vacuum-capped, taken out, and the aluminum-pressed cap is labeled, the freeze-dried product can be obtained.

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PUM

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Abstract

The invention provides a pervone vincamine injection and a preparation process thereof, relating to the technical field of pervone vincamine injections and preparation processes thereof. The injection is a solution type injection or frozen powder injection, and the solution type injection is divided into a water injection and a drug-carried type infusion solution, wherein the contained active constituent is the pervone vincamine, and the pervone vincamine can exit in the form of soluble salt. The invention has the advantages that compared with the prior art, the injection has the characteristics of unique formulation, convenient use, fast curative effect, safety, reliability and the like, and is applied to the clinical treatment, in particular to the intravenous injection for some patients who can not swallow drugs due to all kinds of reasons or can not carry out the oral administration due to the gastrointestinal tract dysfunction; and the preparation process is simple, convenient and economical, is easy for industrial production, has high economic and social benefits, and solves the key problem that the solubility of the pervone vincamine is lower in water because the pervone vincamine belongs to alkaloids in tryptophane system. It is especially significant to develop a pervone vincamine aqueous solution applied to the clinical treatment.

Description

technical field [0001] The invention relates to the technical field of vincamine injection and its preparation. Background technique [0002] Vincamine is an alkaloid extracted from the vinca flower of the Apocynaceae plant, which can increase cerebral blood flow, acting directly as a vasodilator or indirectly by increasing brain metabolism. Studies have shown that vincamine can maintain and restore the oxidative catabolism of glucose, and then restore the physiological carbon dioxide tension to maintain or restore the physiological expansion of cerebral blood vessels, increase cerebral blood flow in ischemic areas, and improve the brain's response to blood oxygen. utilization rate. Vincamine can also inhibit platelet aggregation, improve blood rheological properties, and thus have a good effect on microcirculation. During the medication period, vincamine can reduce the ischemic site, improve memory and improve behavior, but it does not cause changes in arterial partial pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/4375A61P9/12
Inventor 李荣立
Owner 李荣立
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