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Application of anemarrhenasaponin B-II in preparing antidepressant product

A technology of timosaponin and anti-depression, which is applied in the field of medicine and food, and can solve the problems of timosaponin B-II prevention, diagnosis, detection, protection, treatment and research of depression and its direct related diseases.

Inactive Publication Date: 2008-07-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0073] According to literature search, so far, no reports on the use of timosaponin B-II in the prevention, diagnosis, detection, protection, treatment and research of depression and its directly related diseases have been found.

Method used

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  • Application of anemarrhenasaponin B-II in preparing antidepressant product
  • Application of anemarrhenasaponin B-II in preparing antidepressant product

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0132] (1) Preparation and identification method of timosaponin B-II

[0133] The preparation method of said timosaponin extract of the present invention comprises the following steps:

[0134] (1) Extraction: take some Anemarrhena raw materials, extract, and obtain an extract, that is, the total extract of Anemarrhena;

[0135] (2) Separation and purification: the extract is separated and purified to obtain the total maternal saponin extract.

[0136] The extraction method includes all available methods known in the art such as solvent extraction.

[0137] The extraction method of the solvent extraction method described above is a conventional extraction method in the art, that is to say, it includes the commonly used ultrasonic extraction method, immersion extraction method, percolation extraction method, decoction extraction method, heating reflux extraction method or continuous reflux extraction method. One or more of extraction methods, etc.; the number of extractions m...

Embodiment 1

[0162] Embodiment 1, the preparation method of timosaponin B-II

[0163] The preparation method of Anemarrhena total saponins extract is:

[0164] (1) Extraction: thermally extract the pulverized Anemarrhena medicinal material with 20-95% ethanol according to the routine, and the volume of solvent used for the first time is about 4-8 times that of the crude drug; or percolate the pulverized Anemarrhena medicinal material with 20-95% ethanol For extraction, the solvent volume is about 4 to 12 times that of the crude drug; the extract is obtained; the extract is filtered and concentrated, and the concentrate is centrifuged or filtered;

[0165] (2) Separation and purification: the centrifuged supernatant or filtrate of the concentrated solution is adsorbed by non-polar or weakly polar macroporous resin (non-polar or weakly polar macroporous resin is polystyrene with styrene as bridging material) Ethylene-type porous adsorption resin, such as D101, D201, ZTC-1, AB-8, 1300-1 type...

Embodiment 2

[0169] Embodiment 2, the preparation method of timosaponin B-II

[0170] Put 100 kg of pulverized anemarrhena medicinal materials into the extraction tank, heat-extract three times with 400 liters of 70% ethanol at 90-100 ° C, each extraction time is 90 minutes, combine the three extracts, concentrate to 80 liters, and filter , the filtrate was adjusted to 100 liters with distilled water. Then slowly pass through the adsorption column that 350 liters of ZTC-1 type macroporous resin (produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd.) is housed, remove impurities by eluting with 500 liters of distilled water and 1000 liters of 20% ethanol, and then use 1000 liters of 45% ethanol to remove impurities. Eluted with ethanol, collected the eluent, concentrated to dryness, dried and pulverized to obtain a yellow powder, which was the total saponin extract of Anemarrhena, weighing 2.7 kg in total, and the yield was 2.7% based on the crude drug amount.

[0171] The ...

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Abstract

The present invention relates to a novel purpose of timosaponin B-II. The anti-depression test of the timosaponin B-II in total timosaponin extract shows obvious anti-depression activity; The present invention has strong pharmacological effect and stable quality; the raw material of the present invention has abundant source, cheap price and is safe with low toxin; the present invention has simple preparation technology and high yield, which provides a novel medicine source for preventing, diagnosing, examining, protecting, remedying and researching on the depression and diseases directly related to the depression, is fit for the industrialization production, is easy for popularizing, applying and has very important value for developing and using Chinese officinal plant resource. Affective mental disorder is listed at top in Chinese disease general burden, and the research and manufacture of the drug for preventing and remedying the depression has obvious social benefit and economic benefit.

Description

technical field [0001] The invention relates to the technical fields of medicine and food, in particular to the use of Chinese medicine extracts, and more specifically to the use of Chinese medicine extract timosaponin B-II in preparing antidepressant products. Background technique [0002] (1) An overview of the research on Zhimu [0003] Anemarrhena (Rhizoma Anemarrhenae) is the rhizome of Anemarrhena asphodeloides Bunge, a plant of the Liliaceae family. It is also known as Garlic clove grass and Lianmu. It is born in mountains, dry hills or grasslands, mainly in Hebei. It is excavated every spring and autumn, removes fibrous roots and soil, and dries in the sun, which is commonly called "Mao Zhimu"; removes the outer skin, and is called "Anemarrhena meat" when dried in the sun. [0004] Anemarrhena is a perennial herb. Ye Jisheng, linear, slightly hard, 20-70cm long, 0.3-0.6cm wide. Flower stems 40-60cm high, scattered with scale-like bracteoles; 2-6 flowers scattered ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/24A61K36/8964
Inventor 伊佳陈万生李铁军邱彦孙连娜毛俊琴
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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