Cinnamaldehyde nanoemulsion bacteriostatic agent and preparation method thereof

A technology of cinnamaldehyde and nanoemulsion, which is applied in the directions of antibacterial drugs, emulsion delivery, aldehyde active ingredients, etc., can solve the problems of low antibacterial efficiency, drug resistance, negative environmental impact, etc., and achieve good antibacterial and bactericidal effects, toxicity The effect of low side effects and lower production costs

Inactive Publication Date: 2015-12-23
TIANJIN AGRICULTURE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a cinnamaldehyde nanoemulsion bacteriostatic agent to solve the technical problem that the pathogenic bacteria prevention and control drugs used in the water environment generally have a negative impact on the environment in the prior art
[0006] Another technical problem solved by the present invention is the technical problem that the pathogenic bacteria prevention and control drugs used in the water body environment in the prior art have low antibacterial efficiency and easy to produce drug resistance

Method used

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  • Cinnamaldehyde nanoemulsion bacteriostatic agent and preparation method thereof
  • Cinnamaldehyde nanoemulsion bacteriostatic agent and preparation method thereof
  • Cinnamaldehyde nanoemulsion bacteriostatic agent and preparation method thereof

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Embodiment 1

[0038] 1. The formula and preparation of cinnamaldehyde nanoemulsion bacteriostatic agent

[0039] A cinnamaldehyde nanoemulsion bacteriostatic agent, the raw material mass percentage is composed of: surfactant (tween 80), cosurfactant (ethanol), oil phase (ethyl acetate), water (distilled water), cinnamaldehyde are respectively 10%, 4%, 11.8%, 73%, 1.2%.

[0040] Its preparation process is as follows:

[0041] At room temperature, first accurately measure 3000mg of Tween 80 and 1500mg of ethanol, fully mix under the action of 600r / min magnetic stirring to obtain mixture A; then accurately measure 3600mg of ethyl acetate and mixture A under the action of 600r / min magnetic stirring Mix thoroughly to obtain mixture B; then add distilled water dropwise to mixture B while stirring, until the system gradually becomes turbid from the clear oil phase with smaller viscosity, and then with the addition of distilled water, the mixture suddenly becomes rare And translucent, obtain mixt...

Embodiment 2

[0061] A cinnamaldehyde nano-emulsion bacteriostatic agent is characterized by comprising the following components in percentage by weight: 809% of Tween, 4% of ethanol, 11% of ethyl acetate, 0.9% of cinnamaldehyde, and the balance of water.

[0062] The particle size of the cinnamaldehyde nanoemulsion bacteriostatic agent is 10 nm.

[0063] The preparation method of the described cinnamaldehyde nanoemulsion bacteriostatic agent comprises the following steps:

[0064] 1) get the surfactant of the formula amount and mix with the cosurfactant to obtain the first mixture;

[0065] 2) get the first mixture described in step 1) and mix with the oil phase of the formula amount to obtain the second mixture;

[0066] 3) under stirring conditions, drip the water of the formula amount to the second mixture described in step 2) to obtain a blank nanoemulsion;

[0067] 4) adding the cinnamaldehyde of the formula amount to the blank nanoemulsion described in step 3) under stirring condit...

Embodiment 3

[0070] A cinnamaldehyde nano-emulsion bacteriostatic agent comprises the following components in percentage by weight: Tween 8010%, ethanol 5%, ethyl acetate 13%, cinnamaldehyde 1.2%, and water balance.

[0071] The particle size of the cinnamaldehyde nanoemulsion bacteriostatic agent is 100 nm.

[0072] The preparation method of the described cinnamaldehyde nanoemulsion bacteriostatic agent comprises the following steps:

[0073] 1) get the surfactant of the formula amount and mix with the cosurfactant to obtain the first mixture;

[0074] 2) get the first mixture described in step 1) and mix with the oil phase of the formula amount to obtain the second mixture;

[0075] 3) under stirring conditions, drip the water of the formula amount to the second mixture described in step 2) to obtain a blank nanoemulsion;

[0076] 4) adding the cinnamaldehyde of the formula amount to the blank nanoemulsion described in step 3) under stirring conditions, and mixing to obtain the cinnama...

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Abstract

The invention provides a cinnamaldehyde nanoemulsion bacteriostatic agent and a preparation method thereof. The cinnamaldehyde nanoemulsion bacteriostatic agent takes 0.9-1.2% of cinnamaldehyde as an antibacterial ingredient and is prepared into nanoemulsion from 9-10% of surfactants, 4-5% of cosurfactants, 11-13% of oil and water, thereby being excellent in water solubility and making use of the cinnamaldehyde for preventing and controlling pathogenic microorganisms in a water body possible. Compared with the prior art, the cinnamaldehyde nanoemulsion bacteriostatic agent and the preparation method thereof have the advantages that environmental pollution caused by use of antibiotics and chemical disinfectants can be avoided; the cinnamaldehyde nanoemulsion bacteriostatic agent has good bacteriostatic and bactericidal effects, and pathogenic bacteria are less prone to production of drug tolerance; the preparation method is simple, net content of the cinnamaldehyde is high, quality of the cinnamaldehyde is stable, and accordingly, the cinnamaldehyde nanoemulsion bacteriostatic agent is suitable for large-scale production; the cinnamaldehyde nanoemulsion bacteriostatic agent, which is soluble in water and stable in property after dissolving in water, can be widely applied to disinfection of an aquaculture pond water body and prevention and control of common aquaculture fish pathogenic bacteria.

Description

technical field [0001] The invention relates to the technical field of aquaculture, in particular to a cinnamaldehyde nanoemulsion bacteriostatic agent and a preparation method thereof. Background technique [0002] In aquaculture technology, disease prevention and control is an important means to ensure production. Among the common diseases of aquatic animals, diseases caused by pathogenic microorganisms are the most serious. On the one hand, such diseases are contagious and prone to outbreaks. Diseases have a great impact on yield and even lead to the death of aquatic animals. In the prior art, antibiotics and chemical disinfectants are mainly used for the prevention and treatment of various aquatic animal pathogenic bacteria. Although the use of such methods is effective, a large amount of investment and its irrational use will produce toxic and side effects on aquaculture objects. The drug resistance of pathogenic bacteria is enhanced, and there are certain residues in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/11A61P31/04
Inventor 王庆奎姚维林陆颖石洪玥孙学亮毕相东陈成勋郭永军邢克智
Owner TIANJIN AGRICULTURE COLLEGE
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