109results about How to "Solving Medication Problems" patented technology

The invention relates to a preparation method and application of hyaluronic acid modified by vitamin E succinate and is capable of effectively solving the problems of preparation of hyaluronic acid modified by vitamin E succinate and the application in antitumor drugs. The preparation method comprises the following steps: with alkylidene diamine or dithio alkylidene diamine as a linking arm, hyaluronic acid is covalently linked to vitamin E succinate according to the weight ratio of 1:(1-100) so as to form a nano-micelle in a water medium, wherein hyaluronic acid is low-molecular-weight hyaluronic acid with the molecular weight no less than 600 daltons and no larger than 400kd; the linking arm is the alkylidene diamine or the dithio alkylidene diamine with the amount of carbon atoms being 2-12, and a disulfide bond in the dithio alkylidene diamine has the oxidation-reduction sensitivity in vivo and is capable of releasing the antitumor drugs in a targeting mode in tumor cells. With HA as a skeleton, hyaluronic acid modified by vitamin E succinate is high in drug loading capacity and easy in releasing of the drugs, is effectively used for preparing the antitumor drugs, is capable of solving the problem of medication for treating tumors and is an innovation of the drugs for treating the tumors.

A fast dispersing solid Chinese medicine for restoring health is prepared from 13 Chinese-medicinal materials including cablin potchouli herb, perilla leaf, tangerine peel, liquorice root, etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.

The invention relates to a fullerene-nanogold composite material as well as a preparation method and application thereof and aims at effectively solving the problems of preparation of the fullerene-nanogold composite material and application of the fullerene-nanogold composite material serving as a radio-frequency or microfiltration irradiation medicament in tumor in-situ advanced photothermal therapy. The preparation method comprises the following steps of: dissolving a fullerene amination derivative in an organic solvent A, adding sodium hydride, uniformly stirring, adding bromomalonic acid diethyl ester, removing the sodium hydride and the organic solvent A, and carrying out vacuum drying to obtain fullerene substituted by the bromomalonic acid diethyl ester; adding the fullerene substituted by the bromomalonic acid diethyl ester and the sodium hydride into the organic solvent A, magnetically stirring until the mixture colorless, removing the organic solvent A, adding concentrated hydrochloric acid, filtering to obtain a filter cake, dissolving the filter cake in methanol, removing undissolved substances, carrying out rotary evaporation to remove the methanol, and carrying out vacuum drying to obtain a fullerene carboxylation derivative; adding the fullerene carboxylation derivative into a chloroauric acid water solution, then adding a solution B, ethanol or acetone, filtering to obtain a filter cake, washing the filter cake by using ethanol or acetone, and carrying out vacuum drying to obtain the fullerene-nanogold composite material. The preparation method is easy to operation; the fullerene-nanogold composite material has a good effect and is an innovation of antitumor medicaments.

The Chinese medicine powder for treating nasosinusitis as well as rhinitis, chronic rhinitis, erosive nasal septum is prepared with 18 kinds of Chinese medicinal materials including thunberg fritillary bulb, Chuanxiong rhizome, glabrousleaf pittosporum seed, flavescent sophora root, dahurian angelica root, etc. which are produced into medicine powder and capsulized. The medicine has high curative effect and no toxic side effect.

A fast dispersing solid Chinese medicine for clearing stomach is prepared from 24 Chinese-medicinal materials including rhubarb, coptis root, haw, tangerine peel etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.

The embodiment of the invention provides a drug efficacy optimization method and device based on blood drug concentration monitoring. The method comprises the steps: establishing a drug efficacy optimization sample database based on blood drug concentration monitoring, and each sample in the drug efficacy optimization sample database includes medication order information in case of normal blood drug concentration and the test item data closest to the time before taking the drug; performing missing value processing and significance testing on the drug efficacy optimization sample database so asto obtain the pretreated drug efficacy optimization sample database; performing supervised learning by using the XGBoost algorithm according to the pretreated drug efficacy optimization sample database and constructing a drug efficacy optimization model; and inputting the test item data to be predicted to the drug efficacy optimization model to obtain the medication order information corresponding to the test item data to be predicted. The drug efficacy optimization scheme of higher practicality can be predicted according to the test result of the patient so as to solve the medication problemof the patient in the complex situation and realize individualized drug efficacy optimization.

A fast dispersing solid Chinese medicine forwarming uterus is prepared from 10 Chinese-medicinal materials including cinnamon bark, Chinese angelica root, Chuan-xiong rhizome, white peony root, etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.

The invention discloses a medicine for eliminating phlegm and stopping cough, relieving dyspepsia and activating blood and dissolving stasis and a preparation method thereof. The medicine is a sugarless seabuckthorn granule made up of a seabuckthorn extract (a solid matter), mannite, dextrine, soluble starch and steviosin. The medicine has advanced production technique, good drug effect, low dosage, and is convenient for taking and carrying. In addition, the medicine solves the problems on drug taking for patients with diabetes, obesity, cardiovascular diseases and decayed tooth, and obtains unexpected effects.

The invention relates to a traditional Chinese medicine for treating breast hyperplasia and breast cancer. The traditional Chinese medicine can be used for effectively solving the treatment medicinal problems of the breast hyperplasia and breast cancer. The technical scheme for solving the problems is as follows: the traditional Chinese medicine is prepared from radix curcumae processed with vinegar, trigone processed with vinegar, rhizoma zedoariae processed with vinegar, processed pangolin, seaweed, iphigenia indica, radix codonopsitis, astragalus root, fruit of glossy privet, honeysuckle, lithospermum, chrysanthemum, rhizoma cyper processed with vinegar, trichosanthes, rubia root, corydalis tuber processed with vinegar, uniflower swisscentaury root, rhizoma coptidis, processed vomiting nut, chilopod, rheum officinale, fried cowherb seed, fried mustard seed, tangerine seed, prepared frankincense, prepared myrrh, oarweed and paris polyphylla. The material medicines are crushed and prepared into pills by using water and dried, respectively. The material medicines are effectively combined and supported with each other to achieve the effects of detoxicating and resolving a mass, tonifying qi and dredging collaterals, and promoting blood circulation to remove blood stasis. Besides, the traditional Chinese medicine is effectively used for treating the breast hyperplasia and breast cancer, and is safe in medicine use, good in curative effect and innovative on medicines for treating the breast hyperplasia and breast cancer.

A fast dispersing solid Chinese medicine for invigorating the function of infantile spleen is prepared from 8 Chinese-medicinal materials including yam, chickení»s gizzard-skin, white atractylodes rhizome, tendrilled fritillary bulb, etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.

The invention discloses an antiviral drug which can be taken orally or molten - a ribavirin tablet and a manufacturing method thereof. The compositions of the preparation by weight percent are 3.8 to 20 percent of ribavirin, 71 to 83.25 percent of sugar and 9 to 12.95 percent of other pharmaceutic adjuvant. The manufacturing method comprises the following steps: 80 meshes of the ribavirin, 80 meshes of the sugar and other filler and disintegrating agent between 80 meshes and 100 meshes are taken and mixed; an adequate bonding agent is added into the mixture and particles are prepared, boiled, dried and integrated and added with lubricant; after uniform mixture, the weight of a stator plate is tested, and tabletting is performed; and after test qualification, packaging and full inspection are performed. The preparation lightens the passivity of patients in taking medicine and particularly solves the problem of medicine taking of infants, old patients, dental patients, upper respiratory tract virus infection patients and so on; and as shown by production for a plurality of years and sampling stability study, the quality of the preparation is stable.

A fast dispersing solid Chinese medicine for clearing lung is prepared from 24 Chinese-medicinal materials including mulberry bark, honeysuckle flower, scutellaria root, liquorice root, etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.

The invention relates to a medicinal grease for relaxing vein and removing pain, and process for preparation, wherein the grease is prepared from Chinese angelica root, Ligusticum wallichii, safflower, Resurrectionlily rhizome, pricklyash peel, piper nigrum, clove, Cinnamomum cassia, long pepper, dried ginger, rhubarb horsetails, camphor, baras camphor and mentha-camphor through steps of disintegrating, impregnating with ethanol, carrying out diacolation, charging gasoline for abstraction, separating ethanol, obtaining extract oil, subjecting Cinnamomum cassia to ethanol diacolation, extracting with gasoline, percolating extracted medicinal dross with ethanol, collecting the percolation liquid, obtaining extract through decompression and concentration, making base material from rubber, colophony, Vaseline, fluid wax, zinc oxide, dimethyl sulfoxide and gasoline, charging concrete, extractive oil and camphor, mixing homogeneously and applying onto base fabrics.

The invention discloses a prochloraz and thiodiazolecopper compound medicament for preventing and controlling rice seed-borne fungus and bacterium diseases. The active ingredients of the medicament comprise N-propyl-N-[alpha-(2,4,6-trichlorophenoxy)-1H-imidazole-1-formamide and 2-amino-5-mercapto-1,3,4-thiodiazole in a mass ratio of (3-9):(7-1). The medicament disclosed by the invention has effects of radically killing seed-borne pathogenic fungi and bacteria and provides new technical support for preventing and controlling spread of rice seed-borne fungus and bacterium diseases and damage.

A Chinese medicine in the form of plaster for treating bony arthritis is prepared from 9 Chinese-medicinal materials including Chinese angelic root, Chuanqiong rhizome, dried ginger, cinnamon bark, etc and the matrix prepared from rubber, rosin, zinc oxide, Vaseline, etc. Its preparing process is also disclosed.

The invention discloses a tebuconazole and thiodiazole-copper blended medicament for preventing and treating rice seed-borne fungal and bacterial diseases. The medicament comprises the following active ingredients: (RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazole-1-ylmethyl)pentyl-3-alcohol and 2-amino-5-sulfydryl-1,3,4-thiadiazole copper, wherein the mass ratio of the (RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazole-1-ylmethyl)pentyl-3-alcohol to the 2-amino-5-sulfydryl-1,3,4-thiadiazole copper is (1-9):(9-1). The medicament disclosed by the invention has an effect on thoroughly killing pathogenic fungi and bacteria carried in seeds, thereby providing a new technical support for preventing and controlling the propagation, spread and harm of rice seed-borne fungal and bacterial diseases in production.

The invention relates to a traditional Chinese medicine for treating premature ovarian failure. The traditional Chinese medicine can be used for effectively solving the problem of medication of premature ovarian failure. The technical scheme for solving the problem is as follows: the traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 5-20 parts of glossy privet fruit, 5-20 parts of barbary wolfberry fruit, 3-12 parts of donkey-hide glue, 5-25 parts of palmleaf raspberry fruit, 1-5 parts of dried human placenta, 3-10 parts of tokay, 5-15 parts of Chinese caterpillar fungus, 5-15 parts of turmeric root-tuber, 10-30 parts of akebia fruit, 5-20 parts of Chinese angelica, 10-20 parts of salvia miltiorrhiza and 3-10 parts of motherwort fruit. The traditional Chinese medicine provided by the invention is rich in raw material, low in price, scientific in composition and reasonable in compatibility, and the medicinal materials support one another and act together to achieve the effects of nourishing yin and blood, enriching kidney essence, soothing the liver and relieving depression, as well as nourishing blood and promoting blood circulation, so that the traditional Chinese medicine is good in curative effect and safe in medication when effectively used for treating the premature ovarian failure, and is a big innovation of medicaments for treating the premature ovarian failure.

A fast-dispersing Chinese medicine in the form of solid is prepared proportionally from motherwort, Chinese angelica root, Chuan-xiong rhizome and aucklandia root through crushing or extracting, superfine pulverizing, mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent, and conventional steps.

A fast dispersing solid medicine for strengthening middle energizer to nourish qi is prepared from 8 Chinese-medicinal materials including astragalus root, pilose asiabell root, liquorice root, Chinese angelica root, etc. Its preparing process is also disclosed.

A Chinese medicine in the form of fast dispersing solid is prepared from 8 Chinese-medicinal materials including anemarrhena rhizome, pellodendron bark, tree peony bark, yam, etc.

The invention relates to an oral ulcer healing membrane with traditional Chinese medicine bioadhesive one-way medicine release, capable of effectively solving the problem of used medicines for treating the oral ulcer. The technical scheme for solving the problem is as follows: the ulcer healing membrane is prepared by the following materials: 10-13g of figwortflower picrorhiza rhizome, 10-13g of tree peony bark, 8-11g of natural indigo, 1.5-2.5g of borneol, 2-4g of Carbomer 934P, 2-4g of hydroxy propyl cellulose, 2.3-2.5g of sodium cyclamate, 10-14ml of glycerin and ethyecellulose and absolute ethyl alcohol. The invention has reasonable compatibility of components, advanced and unique method, convenient use and good treatment effect and is innovation for treating oral ulcer.

The invention relates to an anti-tumor-metastasis Chinese medicament capable of effectively solving the problems of medication of anti-tumor metastasis. The technical scheme used for solving the problems is that the Chinese medicament is prepared from the following bulk medicaments in parts by weight: 10-30 parts of largehead atractylodes rhizome, 10-30 parts of white poria, 10-30 parts of catclaw buttercup, 10-30 parts of yangtao actinidia root, 10-30 parts of doederlein's spikemoss herb, 10-60 parts of hairyvein agrimonia herb and bud, 9-30 parts of fiveleaf gynostemma herb, 5-20 parts of Chinese trumpet creeper and 10-30 parts of Chinese sage herb. The Chinese medicament is prepared through the steps of firstly mixing the bulk medicaments together, adding water of which the weight is 8-10 times that of the bulk medicaments, soaking for 2-4 hours, decocting for 30-40 minutes, and filtering to obtain first filtrate; adding the water of which the weight is 8-10 times that of the bulk medicaments into medicament dregs again, decocting for 30-40 minutes, and filtering to obtain second filtrate; combining the filtrate of the two times. The Chinese medicament disclosed by the invention is abundant in raw materials, has the effects of detoxifying, resolving masses, invigorating the circulation of blood, tonifying qi and strengthening the spleen, is definite in curative effect and good in use effect, and provides an innovation for anti-tumor-metastasis medicaments.

The invention relates to an application of total glycosides of verbena in the preparation of medicines for controlling cerebral ischemia. So a problem of the preparation of the medicines for controlling cerebral ischemia can be effectively solved. A technical scheme for solving the problem comprises the following steps: 1, crushing a medicinal material verbena, adding with ethanol, immersing, carrying out refluxing extraction, carrying out reduced pressure distillation for ethanol recovery until no alcohol flavor, concentrating to the relative density of 1.20 (60DEG C), adding with water, allowing to stand for a night, adjusting the pH value, and carrying out low temperature and reduced pressure concentration on a filtrate to obtain an extraction concentrate of verbena; and 2, carrying out wet column-packing with a macroporous adsorption resin, adsorbing for 12h with the blade diameter length ratio of a column of 1:8, eluting impurities with water, then eluting with ethanol, collecting an ethanol eluate, carrying out reduced pressure concentration, drying, and crushing to obtain the total glycosides of verbena. The total glycosides of verbena allows problem of the realization of controlling cerebral ischemia through preparing the medicines for treating cerebral ischemia to be effectively solved. A method for preparing the total glycosides of verbena which has the advantages of simplicity, abundant raw material, good application effect and allows a usage problem of treating cerebral ischemia to be effectively solved is an innovation in the field of traditional Chinese medicines.

The invention relates to an application of ilex pubescens total saponin in preparing a drug for preventing and treating transient ischemic attack syndrome, which can effectively realize the aim of preparing the drug for preventing and treating transient ischemic attack syndrome. In the technical scheme provided by the invention, the method comprises the following steps of: taking ilex pubescens drug, and adding alcohol, wherein the weight of the alcohol is 10 times that of the drug and the mass concentration is 70%; dipping for 30min, extracting for 1h, and recovering liquid drug; adding alcohol, wherein the weight of the alcohol is 8 times that of the ilex pubescens and the mass concentration is 70% in dregs of a decoction; dipping for 30min, extracting for 1h, and recovering liquid drug; combining the liquid drug generatedfor the first time and the second time; adjusting the pH value of the liquid drug obtained in two times to 4-5, adding macroporous resin; washing a resin column with the alcohol with the mass concentration of 35% to obtain the ilex pubescens total flavone; and washing the resin column with the alcohol with the mass concentration of 70% to obtain the ilex pubescens total saponin. The ilex pubescens total saponin can be effectively used for preparing the drug d for treating transient ischemic attack syndrome and solves the problem of preventing and treating transient ischemic attack syndrome. The preparation method provided by the invention has abundant raw materials and a good application effect, effectively solves the problem of medication for treating the transient ischemic attack syndrome, and is an innovation on the Chinese drug.

The invention relates to a traditional Chinese medicine patch for treating cough and dyspnea, which can be used for effectively solving the drug-use problem of treating the cough and dyspnea. The technical scheme is that the traditional Chinese medicine patch is prepared from the following traditional Chinese medicines by weight: 45g-55g of pink reineckea herb, 45g-55g of clematis chinensis, 45g-55g of jamestownweed seeds, 28g-32g of euphorbia kansui, 45g-55g of raw southern star, 45g-55g of tuber pinellia, 45g-55g of herba ephedrae, 28g-32g of Chinese wild ginger, 45g-55g of kadsura peltigera, 28g-32g of brassica alba boiss, 28g-32g of cordyceps sinensis and 28g-32g of borneols. According to the traditional Chinese medicine patch disclosed by the invention, the materials are abundant, the use is convenient and the curative effect is good, and so the traditional Chinese medicine patch is an innovation on the medicine for treating the cough and dyspnea.

The invention relates to an application of total flavonoids of leek seeds in preparing medicines for treating perimenopausal depression, in order to effectively solve the problem on medication for treating the perimenopausal depression. According the application, a method comprises the following steps: crushing the leek seeds into coarse powder, conducting reflux extraction on the coarse powder with the addition of petroleum ether, conducting degreasing and discarding the petroleum ether; volatilizing dregs of the leek seeds until the petroleum ether is removed, soaking the dregs in ethanol, conducting reflux extraction, decompressing an extracting solution and recovering the ethanol till no alcohol taste, and conducting dispersion with the addition of distilled water, so that a sample solution is obtained; processing the sample solution by virtue of AB-8 type macroporous adsorption resin, sequentially eluting the processed sample solution by virtue of distilled water, ethanol which is 10% in mass concentration and ethanol which is 80% in mass concentration, collecting an eluent of 80% ethanol, conducting decompressing and recovering the ethanol till no alcohol taste, implementing extraction with equal volume of petroleum ether and discarding the petroleum ether; and conducting volatilization to remove an organic solvent, freeze-drying a water course and conducting crushing, so that the total flavonoids of the leek seeds are obtained. The total flavonoids of the leek seeds can be used for effectively preparing the medicines for treating the perimenopausal depression; therefore, the application of the total flavonoids of the leek seeds in preparing the medicines for treating the perimenopausal depression is achieved.

The invention discloses a fungicide of Ustilaginoideavirens or a drug for preventing and treating Ustilaginoideavirens. The active ingredients are composed of 1-(4-chlorophenoxy)-3, 3-dimethyl-1(1H-1, 2, 4-triazole-1-yl)-2-butanol and (E, E, E)-N-methyl-2-[((((1-methyl-3-(2, 6-chlorophenyl)-2-allyl) imino) oxygroup) methyl) phenyl]-2-methoxy imino acetamide, wherein the mass ratio of the 1-(4-chlorophenoxy)-3, 3-dimethyl-1(1H-1, 2, 4-triazole-1-yl)-2-butanol to the (E, E, E)-N-methyl-2-[((((1-methyl-3-(2, 6-chlorophenyl)-2-allyl) imino) oxygroup) methyl) phenyl]-2-methoxy imino acetamide is (2-6): (8-4) or (9:1). The triadimenol and syp-1620 mixed drug disclosed by the invention solves the drug use problem in practical rice production and has a wide application prospect in the field of agricultural fungicide. Industrialization is carried out on the triadimenol and syp-1620 mixed drug to bring economic benefit, novel drug is adopted and drugs with different action mechanisms are mixed to beneficially delay the generation of resistance to drugs, and the triadimenol and syp-1620 mixed drug has remarkable economic, ecological and social benefits.

The invention aims to provide a marrow-nourishing traditional Chinese medicinal capsule for treating apoplexy. The capsule is prepared from the following raw medicinal materials: scorpion, centipede,little multibanded krait, leech, ground beetle, Lumbricus, muscardine silkworm, wolfberry, fructus alpiniae oxyphyllae and paper mulberry fruit. A preparation method of the capsule comprises the following steps: crushing scorpion, centipede, little multibanded krait, leech and a half of fructus alpiniae oxyphyllae into fine powder; adding water to a mixture of ground beetle, Lumbricus, muscardinesilkworm, wolfberry, the residual fructus alpiniae oxyphyllae and paper mulberry fruit; decocting and filtering to obtain a first decoction; adding water to herb residue and decocting, and filtering to obtain a second decoction; adding water to herb residue and decocting, and filtering to obtain a third decoction; mixing the three decoctions; concentrating to obtain an extract with relative density of 1.05-1.10; drying and crushing; uniformly mixing with the above fine powder; granulating; drying; straightening granulating; and capsulating to obtain 1000 capsules. The formula is scientific; raw materials are rich; and the capsule is easy for production and preparation, is convenient to use, has good effects, is a great innovation in Chinese traditional treatment, and has great economic andsocial benefits.

The invention relates to a traditional Chinese medicine for treating diabetic depression.The traditional Chinese medicine effectively solves the problem of drug usage for treating the diabetic depression.According to the technical scheme for solving the problem, the traditional Chinese medicine is prepared from, by weight, 6-20 parts of radix bupleuri, 3-15 parts of betel nuts, 9-30 parts of fiver-leaf akebia fruits, 9-20 parts of poria cocos, 6-20 parts of white atractylodes rhizomes, 10-30 parts of a centella asiatica extract, 6-15 parts of a creeping woodsorrel herb, 6-15 parts of rhodiola rosea, 6-25 parts of lotus seeds and 3-12 parts of platycladi seeds.The traditional Chinese medicine has the effects of soothing the liver, regulating vital energy, tonifying spleen to remove dampness and tranquilizing mind by nourishing the heart, can effectively improve the clinical symptoms of patients with the diabetic depression and is innovative on the aspect of drugs for treating the diabetic depression.