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Motherwort quick dispersion solid prepn. and its prepn. method

A solid preparation and rapid technology, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, can solve the problems of obsolete preparation technology and inconvenient use, and achieve convenient administration, rapid dispersion, and improved bioavailability degree of effect

Inactive Publication Date: 2006-06-14
JIANGXI HUIREN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Yimu Pills are already on the market in China, but in practice, the disadvantages of Yimu Pills are that the preparation process is outdated, and the dosage form is honeyed pills, which is inconvenient to use and brings a lot of trouble to the elderly, young and patients with dysphagia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Motherwort 480g, Angelica 240g, Rhizoma Chuanxiong 120g, Woody Fragrance 45g, the above four flavors, pulverized into fine powder, mixed evenly, superfinely pulverized, passed through 400 mesh, every 100 parts of powder and auxiliary materials were mixed evenly, the powder was pressed into large tablets (3g), Coat it with Neofil coating material, and it is ready. This product is a dispersible tablet, 1-2 tablets at a time, put into about 150-200ml of water and disintegrate into a uniform solution before taking; twice a day. The preparation prescription is shown in Table 1:

[0057] main drug dose 1

[0058] Note: (1) The amount of the main drug is 100 parts, and the amount of other excipients is the relative amount, the number of parts. (2) Others are flavoring agents and the like. (the same below)

Embodiment 2

[0060] Motherwort 800g, Angelica (wine fried) 400g, Rhizoma Chuanxiong 100g, Rehmannia glutinosa 400g, Paeoniae Alba (fried with bran) 100g, the above five flavors, take Motherwort and chop it, add water and decoct twice, each time for 2 hours, combine the two filtrates, the filtrate Concentrate to a clear paste with a relative density of 1.21 to 1.25 (thermal measurement), dry, and pulverize into fine powder; the other four flavors such as angelica are pulverized into fine powder, sieved, and mixed; Mesh; mix every 100 parts of powder and auxiliary materials evenly, granulate and press into large tablets (2g). This product is a buccal tablet, taken orally, 1-2 tablets at a time, or taken after disintegrating into a uniform solution in about 150-200ml of water; 2-3 times a day. The preparation prescription is shown in Table 2:

[0061] main drug dose

Embodiment 3

[0063] Motherwort 1500g, Angelica 100g, Chuanxiong 100g, Ginseng (sugar ginseng) 100g, Atractylodes macrocephala (stir-fried with bran) 100g, Radix Paeoniae Alba 100g, Licorice 100g, Rehmannia glutinosa 100g, Poria cocos 100g, the above nine flavors, Motherwort decoction twice, each time After 2 hours, combine the decoction, filter, concentrate the filtrate into a thick paste, dry at low temperature, and pulverize into fine powder; the other eight flavors such as angelica are pulverized into fine powder; the above powders are mixed, ultrafine pulverized, and passed through 400 mesh; per 100 parts Mix the powder and auxiliary materials evenly, granulate and press into large tablets. This product is a fast-disintegrating tablet, taken orally, 2-3 tablets at a time, or taken after disintegrating into a uniform solution in about 150-200ml of water, 2-3 times a day. The preparation prescription is shown in Table 3:

[0064] main drug dose

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PUM

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Abstract

A fast-dispersing Chinese medicine in the form of solid is prepared proportionally from motherwort, Chinese angelica root, Chuan-xiong rhizome and aucklandia root through crushing or extracting, superfine pulverizing, mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent, and conventional steps.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a fast-dispersing solid preparation with traditional Chinese medicine Yimu and a preparation method thereof. technical background [0002] Yimu Pill is a prescription of "Standards of Chinese Patent Medicine issued by the Ministry of Health" and "Chinese Pharmacopoeia". It is composed of motherwort, angelica, Chuanxiong, woody and other drugs. , caused by blood deficiency and blood cold: irregular menstruation, abdominal pain and leucorrhea, backache and fatigue, blood deficiency, dizziness, tinnitus, postpartum septicemia. Yimu Pills and its derived Siwu Yimu Pills, Ginseng Yimu Pills, Puerperal Yimu Pills, Bazhen Yimu Pills, Antaiyi Pills, etc. Mother pills, etc.: [0003] (1) Yimu Pills (Volume 09 of "Standards of Chinese Patent Medicine of the Ministry of Health", standard number WS3-B-1811-94) [0004] [Prescription Preparation] Motherwort 480g, Angelica 240g,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/20A61P15/00
Inventor 耿炤杨明宋浩亮蔡金娜
Owner JIANGXI HUIREN PHARMA CO LTD
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