Fullerene-nanogold composite material as well as preparation method and application thereof

A composite material and fullerene technology, which is applied in the field of fullerene-gold nanocomposites and its preparation, can solve problems that have not yet been applied, and achieve effective tumor treatment, easy operation, and good results

Inactive Publication Date: 2013-09-25
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no application of fullerene-nano-gold composites in in situ de

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In the concrete implementation of the present invention, its preparation method is realized by the following steps:

[0019] 1) Preparation of fullerene amino derivatives. The method is to aminate fullerene according to the method given in "A Water-Soluble Fullerene and Its Application" of Patent Application No. 201210406707.3 to obtain fullerene amino chemical derivatives;

[0020] 2) Dissolve 90mg of fullerene aminated derivatives in 90ml of toluene, add 0.45g of sodium hydride, stir evenly, add 0.27ml of diethyl bromomalonate and stir evenly, remove sodium hydride by filtration, and spin evaporate Remove toluene, dry in vacuo, obtain the fullerene substituted by diethyl bromomalonate;

[0021] 3) Add the fullerene substituted by diethyl bromomalonate and 1g of sodium hydride in step 2) to 50ml of toluene, stir magnetically at 80°C until colorless, remove the toluene, add 20ml of concentrated hydrochloric acid, and filter , to obtain a filter cake, dissolve the filt...

Embodiment 2

[0024] In the concrete implementation of the present invention, its preparation method is realized by the following steps:

[0025] 1) Preparation of fullerene amino derivatives. The method is to aminate fullerene according to the method given in "A Water-Soluble Fullerene and Its Application" of Patent Application No. 201210406707.3 to obtain fullerene amino chemical derivatives;

[0026] 2) Dissolve 100mg of fullerene aminated derivatives in 100ml of benzene, add 0.45-0.55g of sodium hydride, stir well, add 0.3ml of diethyl bromomalonate and stir well, filter to remove sodium hydride, spin Benzene was evaporated and dried in vacuum to obtain fullerene substituted with diethyl bromomalonate;

[0027] 3) Add the fullerene substituted by diethyl bromomalonate and 1g of sodium hydride in step 2) to 50ml of benzene, stir magnetically at 80°C until colorless, remove benzene, add 20ml of concentrated hydrochloric acid, filter , to obtain a filter cake, dissolve the filter cake in...

Embodiment 3

[0030] In the concrete implementation of the present invention, its preparation method is realized by the following steps:

[0031] 1) Preparation of fullerene amino derivatives. The method is to aminate fullerene according to the method given in "A Water-Soluble Fullerene and Its Application" of Patent Application No. 201210406707.3 to obtain fullerene amino chemical derivatives;

[0032] 2) Dissolve 110mg of fullerene aminated derivatives in 110ml of tetrahydrofuran, add 0.55g of sodium hydride, stir well, add 0.33ml of diethyl bromomalonate and stir well again, remove sodium hydride by filtration, and spin evaporate Remove tetrahydrofuran and dry in vacuo to obtain fullerene substituted with diethyl bromomalonate;

[0033]3) Add the fullerene substituted by diethyl bromomalonate and 1g of sodium hydride in step 2) to 50ml of tetrahydrofuran, stir magnetically at 80°C until colorless, remove tetrahydrofuran, add 20ml of concentrated hydrochloric acid, and filter , to obtai...

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Abstract

The invention relates to a fullerene-nanogold composite material as well as a preparation method and application thereof and aims at effectively solving the problems of preparation of the fullerene-nanogold composite material and application of the fullerene-nanogold composite material serving as a radio-frequency or microfiltration irradiation medicament in tumor in-situ advanced photothermal therapy. The preparation method comprises the following steps of: dissolving a fullerene amination derivative in an organic solvent A, adding sodium hydride, uniformly stirring, adding bromomalonic acid diethyl ester, removing the sodium hydride and the organic solvent A, and carrying out vacuum drying to obtain fullerene substituted by the bromomalonic acid diethyl ester; adding the fullerene substituted by the bromomalonic acid diethyl ester and the sodium hydride into the organic solvent A, magnetically stirring until the mixture colorless, removing the organic solvent A, adding concentrated hydrochloric acid, filtering to obtain a filter cake, dissolving the filter cake in methanol, removing undissolved substances, carrying out rotary evaporation to remove the methanol, and carrying out vacuum drying to obtain a fullerene carboxylation derivative; adding the fullerene carboxylation derivative into a chloroauric acid water solution, then adding a solution B, ethanol or acetone, filtering to obtain a filter cake, washing the filter cake by using ethanol or acetone, and carrying out vacuum drying to obtain the fullerene-nanogold composite material. The preparation method is easy to operation; the fullerene-nanogold composite material has a good effect and is an innovation of antitumor medicaments.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a fullerene-nano gold composite material and its preparation method and application. Background technique [0002] In 1985, British scientist Kroto, American scientists Curl and Smalley accidentally discovered the third allotrope of carbon, namely fullerene represented by C60. Fullerene has attracted much attention due to its unique structure and properties, and has become a common concern of researchers in physics, chemistry, materials and life sciences. Fullerenes can generate reactive oxygen species under radio frequency or microwave irradiation, and reactive oxygen species include singlet oxygen, superoxide anions, and the like. The quantum yield of pure oxygen in fullerene (φ=0.96) is significantly higher than other representative photosensitizers, such as methylene blue (φ=0.52), rose bengal (φ=0.83), eosin (φ =0.57), etc., and it is predicted to be non-toxic to the human body, th...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
Inventor 史进进张振中马柔柔刘瑞瑗余晓媛张静高君刘艳
Owner ZHENGZHOU UNIV
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