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Application of total glycosides of verbena in preparation of medicines for controlling cerebral ischemia

A technology of verbena and cerebral ischemia, which is applied in the field of medicine and achieves the effects of simple preparation method, abundant raw materials and good application effect.

Inactive Publication Date: 2012-01-11
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Verbena has no public reports on the treatment of cerebral ischemia so far

Method used

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  • Application of total glycosides of verbena in preparation of medicines for controlling cerebral ischemia
  • Application of total glycosides of verbena in preparation of medicines for controlling cerebral ischemia
  • Application of total glycosides of verbena in preparation of medicines for controlling cerebral ischemia

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Embodiment Construction

[0011] The specific implementation of the present invention will be described in detail below in conjunction with the examples.

[0012] In the specific implementation of the present invention, the Verbena medicinal material is crushed, 10 times the amount of ethanol with a mass concentration of 60% is added, soaked for half an hour, and refluxed twice for 1.5 hours for the first time and 1 hour for the second time. Combine the two extracts, recover ethanol under reduced pressure until there is no alcohol smell, concentrate to a relative density of 1.20 (60°C), add 6 times the amount of water, let stand for 10-12 hours overnight, filter, adjust pH to 3.0 with hydrochloric acid, and filtrate Concentrate under reduced pressure at a low temperature of 18-25°C to a solution of 0.6g / mL to obtain verbena extract; the AB-type macroporous adsorption resin is first soaked in ethanol for 2 hours, washed with distilled water until alcohol-free, and the macroporous The adsorption resin wa...

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Abstract

The invention relates to an application of total glycosides of verbena in the preparation of medicines for controlling cerebral ischemia. So a problem of the preparation of the medicines for controlling cerebral ischemia can be effectively solved. A technical scheme for solving the problem comprises the following steps: 1, crushing a medicinal material verbena, adding with ethanol, immersing, carrying out refluxing extraction, carrying out reduced pressure distillation for ethanol recovery until no alcohol flavor, concentrating to the relative density of 1.20 (60DEG C), adding with water, allowing to stand for a night, adjusting the pH value, and carrying out low temperature and reduced pressure concentration on a filtrate to obtain an extraction concentrate of verbena; and 2, carrying out wet column-packing with a macroporous adsorption resin, adsorbing for 12h with the blade diameter length ratio of a column of 1:8, eluting impurities with water, then eluting with ethanol, collecting an ethanol eluate, carrying out reduced pressure concentration, drying, and crushing to obtain the total glycosides of verbena. The total glycosides of verbena allows problem of the realization of controlling cerebral ischemia through preparing the medicines for treating cerebral ischemia to be effectively solved. A method for preparing the total glycosides of verbena which has the advantages of simplicity, abundant raw material, good application effect and allows a usage problem of treating cerebral ischemia to be effectively solved is an innovation in the field of traditional Chinese medicines.

Description

technical field [0001] The invention relates to medicine, in particular to the application of total verbena glycosides in the preparation of drugs for preventing and treating cerebral ischemia. Background technique [0002] Cerebral ischemia is an ischemic cerebrovascular disease, which is a focal brain dysfunction caused by insufficient or interrupted blood supply to the brain. It is a common clinical and frequently occurring disease at present. Ischemic brain injury caused by ischemia is an important cause of damage to the central nervous system, so the prevention and treatment of cerebral ischemia has become one of the hot spots in the current study of cerebrovascular diseases. Common ischemic cerebrovascular diseases include: transient ischemic attack, cerebral infarction and cerebral hemorrhage, etc., which are characterized by multiple incidence rates, multiple disability rates, and multiple recurrence rates. With the acceleration of my country's population aging proc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P9/10
Inventor 苗明三白明苗艳艳
Owner HENAN UNIV OF CHINESE MEDICINE
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