Compound medicine of ginkgo leaf extract and dipyridamole and preparing method thereof

A technology of dipyridamole and ginkgo biloba is applied in the field of medicine for treating coronary heart disease and thromboembolic disease, which can solve the problems of inconvenient use, influence on curative effect, unstable quality and the like, and achieve convenient clinical use, easy transportation and storage. , the effect of improving product quality

Inactive Publication Date: 2003-11-12
张哲峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the defects that the existing ginkgo leaf extract and dipyridamole compound drug only has a small water injection dosage form, unstable quality, inconvenient use, and affects curative effect, and provides a ginkgo leaf extract with good stability and remarkable curative effect. Drug and dipyridamole compound drugs for intravenous administration to improve drug quality and facilitate clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Get 1 kg of Ginkgo biloba extract, add 15 kg of water for injection to dissolve, centrifuge and precipitate, filter the supernatant with filter paper and membrane (pore size ≤ 0.45 μm) successively, and ultrafilter with hollow fiber ultrafiltration membrane (pore size not exceeding 100,000) to obtain Pure extract, measure the ginkgo total flavonoids content in this extract, according to measurement result, add dipyridamole (being 40% of ginkgo total flavonoids), sodium chloride (the final concentration in medicinal liquid is 0.9% in pure extract) %), sodium metabisulfite (the final concentration in the medicinal solution is 0.1%) and disodium EDTA (the final concentration in the medicinal solution is 0.008%), diluted with water for injection to total amount (making the content of the total ginkgo flavonoids amount be 10mg / 100ml ), adjusted the pH value to 4.0, ultrafiltered with a hollow fiber ultrafiltration membrane (pore size not exceeding 100,000), filled in a 100 ml...

Embodiment 2

[0046] Get 2.5kg of Ginkgo biloba extract, add 25kg of water for injection to dissolve. After centrifugal precipitation, the supernatant is filtered with plate and frame, then ultrafiltered with a hollow fiber ultrafiltration membrane (with a pore size of no more than 100,000) to obtain a pure extract, and the total flavonoid content of Ginkgo biloba is measured in the extract. Dipyridamole (being 40% of the total flavonoids of Ginkgo biloba), sodium chloride (being 0.9% in the final concentration of medicinal liquid), sodium thiosulfate (being 0.1% in the final concentration of medicinal liquid) of adding recipe quantity in the extracting solution ) and EDTA calcium sodium (in the final concentration of the medicinal solution is 0.01%), diluted with water for injection to the full amount (making the content of the total flavonoids of Ginkgo biloba is 25mg / 500ml), the pH value is adjusted to 4.0, the hollow fiber ultrafiltration membrane (pore size is not More than 100,000) ul...

Embodiment 3

[0048] Get 5 kg of Ginkgo biloba, soak overnight with 30 kg of ethanol-water (1: 1) solution, reflux extraction twice, the first time for 9 hours, the second time for 7 hours, after the extracts were combined, plate and frame pressure filtration, resin bed (strong acid Anion resin and strong base cationic resin are evenly mixed) to remove impurities, concentrated until alcohol-free, add diatomaceous earth and cyclodextrin to remove tannin, protein, etc., filter, and use hollow fiber ultrafiltration membrane (pore size not exceeding 10 10,000) ultrafiltration to get pure extract, measure the total flavonoids content of Ginkgo biloba in this extract, according to the measurement result, add dipyridamole (40% of the total flavonoids of Ginkgo biloba) and glucose (in The final concentration of medicinal liquid is 5%), vitamin C (in the final concentration of medicinal liquid is 0.2%) and EDTA disodium (in the final concentration of medicinal liquid is 0.008%), water for injection i...

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Abstract

The invention is a manufacturing method for vein medicament of gingkgo leaves extraction materials and di-pyridine compound drug. It is based on that the stability of gingkgo flavone in low thickness aqueous solution is higher than in high thickness aqueous solution, the gingkgo leaves extraction materials and di-pyridine is dissolved at the same time, after the two are frozen and dried into even solid, the stability of gingko flavone is higher than the solid which is only frozen and dried from itself, and produces the infusion agent and powder pin agent. The manufacturing process doesn't use active carbon, but uses middle hole fiber film filtering new technology to wipe off impurities, enhances thep quality of the product. The method is simple, convenient, and good curative effect.

Description

technical field [0001] The invention relates to a medicine for treating coronary heart disease and thromboembolic disease-a compound medicine of ginkgo biloba extract and dipyridamole and a preparation method thereof. Background technique [0002] Ginkgo biloba has been used as medicine in my country for more than 5,000 years, but it is limited to traditional Chinese medicine prescriptions or folk single-test prescriptions. Using modern scientific methods to study Ginkgo biloba, it is found that the most important active ingredients of Ginkgo biloba are ginkgolides and flavonols. Ginkgolide has anti-platelet activating factor effect and can improve blood circulation. Flavonols have the function of eliminating free radicals. In addition to expanding blood vessels, they can also prevent arteriosclerosis. It is also found that Ginkgo biloba extract has an effect on the basic neuron group of human memory, can improve memory, and treat vertigo, tinnitus an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P7/02A61P9/10
Inventor 张哲峰
Owner 张哲峰
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