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Method for preparing surface enhanced Raman substrate

A surface-enhanced Raman and substrate technology, applied in the field of Raman spectroscopy, can solve the problems of unstable self-assembly system, easy aggregation, and lack of in-depth development of nanoparticles, achieve good biocompatibility, and improve detection sensitivity. , the effect of improving system stability

Inactive Publication Date: 2014-08-20
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the research on the self-assembly of nanoparticles in solution has not been carried out in depth, mainly because the self-assembly system itself is unstable and prone to aggregation.

Method used

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  • Method for preparing surface enhanced Raman substrate
  • Method for preparing surface enhanced Raman substrate
  • Method for preparing surface enhanced Raman substrate

Examples

Experimental program
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Effect test

preparation example Construction

[0033] Preparation of gold nano seed solution: first mix 7.5mL, 0.1mol / L cetyltrimethylammonium bromide solution with 0.25mL, 0.01mol / L chloroauric acid solution, then add 0.6mL freshly prepared 0.01mol / L sodium borohydride solution, while magnetically stirring for 2min, stand still at room temperature for 2h for later use.

[0034]Growth solution preparation: Take a well-washed container, add 95mL, 0.1mol / L cetyltrimethylammonium bromide aqueous solution, 4mL, 0.01mol / L chloroauric acid, 0.75mL0.01mol / L Silver nitrate solution, magnetically stirred at the same time; then add 0.64mL, 0.1mol / L sodium citrate as a reducing agent, stir vigorously for 2min, at this time the solution changes from light yellow to colorless transparent solution, as a growth solution.

[0035] Preparation of gold nanorods: add 0.4mL of the prepared gold nanorods solution to the above growth solution to induce the growth of gold nanorods, stir slowly until the solution changes color, and place it at a ...

Embodiment 1

[0043] The synthesis steps were as above, except that step 3) added 5 μL of 20% tetraethylorthosilicate in methanol. Such as Figure 6 (a).

Embodiment 2

[0045] The synthesis procedure was as above, except that step 3) added 10 μL of 20% methanol solution of ethyl orthosilicate to it. Such as Figure 6 (b), Figure 7 (a).

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Abstract

The invention provides a method for preparing surface enhanced Raman substrate, and relates to Raman spectrums. The method comprises the steps that a seed crystal growing method is used for synthetizing a gold nanorod solution, wherein gold nano seeds are synthetized first, then a growing solution is added, silver nitrate is used for adjusting the slenderness ratio of gold nanorods until reaction is completed, the needed gold nanorod solution is obtained, then centrifuging is conducted to remove supernatant liquor, signal molecules are added to be connected to a gold surface, then a polyethylene glycol dressing agent is added to induce the gold nanorods to conduct self-assembling, then a processed nano particle solution is stirred, a TEOS methanol solution is added for reacting, silicon dioxide layers are wrapped on the surfaces of the self-assembled gold nanorods, and the surface enhanced Raman substrate is obtained. Detecting can be directly conducted in the solution, due to self-assembling and the coupling effect of plasma on the surfaces of adjacent nano particles, the electromagnetic field between the nano particles is obviously enhanced, the Raman signals at the position are amplified in a quantity level mode, accordingly, the detecting sensitivity of surface enhanced Raman is greatly improved, and the stability is high.

Description

technical field [0001] The invention relates to Raman spectroscopy, in particular to a method for preparing a stable and highly active surface-enhanced Raman substrate. Background technique [0002] Surface-enhanced Raman scattering refers to the abnormal enhancement of Raman signals on some metal rough surfaces or nanoparticle systems. It can amplify the Raman signal of molecules adsorbed on the metal surface by 10 4 ~10 8 times, the enhancement factor can even be as high as 10 at the hotspot 14 , People have been looking for new enhanced substrates with larger enhancement coefficients and better repeatability. In addition to rough metal surfaces, semiconductors, tips, quantum dots, clusters, etc. have been found to have surface-enhanced Raman effects. Here they are divided into three categories: random rough structure, disordered regular structure and ordered regular structure. [0003] The ordered regular structure is characterized by definite shape parameters, unifor...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/02G01N21/65
Inventor 任磊周樨杨安琪
Owner XIAMEN UNIV
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