Nano-carrier particle controllable in drug release and preparation method thereof

A nano-carrier and particle technology, applied in the field of medicine and biology, can solve the problems of reducing the repeatability, spectral width and spectral overlap of nano-drug carrier particles, achieve a good controllable release effect, solve the effect of early leakage, and reduce toxic and side effects

Inactive Publication Date: 2013-04-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present in this patented technology provides an improved way for delivering small amounts (<0nm) of medicine into cells without causing harm or discomfort during injection. This new particle has controllable releasing properties which allow it to be used effectively inside different types of medications such as vaccines while also being able to track them accurately through Raman scatterings techniques like laser scanning. Overall, these technical improvements improve efficacy and reduce potential health hazards associated with injected substances.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving the efficiency of delivering small chemical agents (chemo) into specific areas inside body through various ways such as making them smaller and easier to administer without causing harmful health issues like leaks from blood vessels during injection procedures.

Method used

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  • Nano-carrier particle controllable in drug release and preparation method thereof
  • Nano-carrier particle controllable in drug release and preparation method thereof
  • Nano-carrier particle controllable in drug release and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] figure 1 Shown is that the nanocarrier particle of controlled release medicine has three-layer core-shell structure, comprises outer layer mesoporous silica, middle layer silica shell layer, inner layer gold nanorod; Described mesoporous silica is Loaded with drugs; the silica shell wraps Raman molecules; the gold nanorods are labeled with Raman molecules; the drugs are directly covalently linked to the mesoporous pores through molecules containing disulfide bonds On the silica, the disulfide bond is cut under the action of intracellular glutathione to release the drug molecule.

[0028] 5,5-dithiobis(2-nitrobenzoic acid) (DTNB) molecule is used as SERS marker, 3,3'dithiodipropionic acid (DTPA) is used to provide disulfide bond molecule, and doxorubic acid Star (DOX) prepares nano-drug carrier particles for drug molecules, and triggers them to release drugs with glutathione solution, including the following steps;

[0029] 1) Preparation of gold nanorod solution. To ...

Embodiment 2

[0038] 5,5-dithiobis(2-nitrobenzoic acid) (DTNB) molecule is used as SERS marker, 3,3'dithiodipropionic acid (DTPA) is used to provide disulfide bond molecule, and doxorubic acid Star (DOX) prepares nano-drug carrier particles for drug molecules, and uses human cervical cancer cells (HeLa cells) as a model to achieve controllable drug release in cells, including the following steps;

[0039] 1) To prepare gold nanorod solution, first prepare gold seeds, mix 2.5mL 0.2M cetyltrimethylammonium bromide (CTAB) solution with 1.5mL 1.0mM tetrachloroauric acid solution at room temperature, stir vigorously and add 0.6mL 0.01M ice-cold sodium borohydride solution, stop stirring after 2 minutes to obtain a brownish yellow seed solution, and then prepare a growth solution, add the following reagents in sequence to 50mL 0.2M CTAB solution at room temperature: 2~4mL 4mM silver nitrate solution , 5mL 15mM tetrachloroauric acid solution, 45mL deionized water, stir slowly and evenly, then add ...

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Abstract

The invention discloses a nano-carrier particle controllable in drug release, which has a three-layer core-shell structure and comprises outer-layer mesoporous silica, an interlayer silica shell layer and an inner-layer gold nanorod; drug is loaded in the mesoporous silica; raman molecule is coated on the silica shell layer; the raman molecule is marked on the gold nanorod; the drug is connected on the mesoporous silica by a molecule containing a disulfide bond in a manner of a covalent bond, and the disulfide bond is cut off under the action of glutathione in a cell, so as to release the drug molecule. The invention also discloses a preparation method of the nano-carrier particle controllable in drug release. The nano-drug carrier particle and the preparation method can effectively avoid advance leakage of the drug and reduce the toxic and side effects of the drug, and simultaneously, SERS (surface enhanced raman scattering) signals are integrated in the nano-drug carrier particle, so that precise optical tracing on the nano-drug carrier particle is realized, great convenience is brought to the research on administration behavior, and can effectively improve the cancer chemotherapy efficiency.

Description

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Claims

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Application Information

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Owner SOUTHEAST UNIV
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