367 results about "Transmethylation" patented technology

The invention provides a risk early warning method and system for stomach cancer postoperative malnutrition, and relates to the technical field of medical treatment, and the method comprises the steps: obtaining gene expression data and clinical indexes of a stomach cancer patient based on a cancer genome map database; gastric cancer methylation data is collected, and a methylation risk scoring model is constructed to determine a methylation risk score; performing quantitative evaluation on the nutritional status of the gastric cancer patient based on a nutritional risk screening tool to obtain a nutritional risk level; determining risk characteristics related to stomach cancer postoperative dystrophy according to the gene expression data, the clinical indexes, the methylation risk score and the nutrition risk grade, and establishing a risk early warning model based on a support vector machine; and acquiring current risk data of the patient side, inputting the current risk data into the risk early warning model, outputting a risk score and a risk level, generating a risk intervention measure according to the risk level, and feeding back the risk intervention measure to the medical care side, so that accurate and comprehensive early warning can be performed on the risk of postoperative malnutrition of the gastric cancer patient, and a timely and effective nutrition intervention scheme is formulated.

The invention provides a non-disease diagnosis purpose 5-hydroxymethylcytosine 5hmC detection method and a non-disease diagnosis purpose 5-hydroxymethylcytosine 5hmC detection kit. The detection method comprises the following steps: S1, glycosylation treatment; s2, carrying out enzyme digestion treatment on the GSREs; s3, carrying out APOBEC deamination treatment; s4, carrying out hydroxymethylation detection; the kit comprises a glycosylation reaction kit, a GSREs enzyme digestion reaction kit, an APOBEC deamination reaction kit and a PCR (Polymerase Chain Reaction) kit. The glycosylation reaction kit comprises a CutSmart buffer solution, UDP-Glucose, a T4-BGT enzyme and nuclease-free water, wherein the CutSmart buffer solution, the UDP-Glucose and the T4-BGT enzyme are used as raw materials; the GSREs enzyme digestion reaction kit comprises a GSREs enzyme, an enzyme digestion reaction buffer solution and nuclease-free water, the APOBEC deamination reaction kit comprises APOBEC, BSA (Bovine Serum Albumin), an APOBEC Reactive buffer solution and nuclease-free water; the PCR kit comprises a PCR reaction solution, a primer and a probe. According to the 5-hydroxymethylcytosine 5hmC detection method and kit for non-disease diagnosis purpose provided by the invention, precise quantification of extremely high specificity of 5hmC is realized, and the detection sensitivity is also improved while the specificity of a detection signal is improved.

The present invention discloses an imidazole derivative, a preparation method thereof, and an application, belonging to the field of organic chemistry. The preparation method of the imidazole derivative of the present invention includes: adding compound 2a and dimethyl sulfate into an organic solvent, heating and reacting to obtain compound 3a; wherein, compound 2a is prepared by adding compound 1a, TrtCl, and a base reagent into a solvent, controlling the temperature at 0-10 °C, mixing evenly and reacting. The present invention also further prepares 2-(1-methylimidazol-5-yl)ethylamine (4a) by using the imidazole derivative. The present invention selects dimethyl sulfate as a methylation reagent and cooperates with a specific protecting group design to achieve the efficient preparation of 2-(1-methylimidazol-5-yl)ethylamine, with a total yield of 82.4%.

The purpose of the present invention is to provide a method for producing a methyl compound. Provided is a method for producing a methyl compound using formic acid.

The invention belongs to the field of chemical medicine analysis, and particularly relates to a method for determining the content of impurities in phloroglucinol trimethyl ether. According to the method provided by the invention, the excessive methylation impurities (2, 4, 6-trimethoxytoluene, 2, 4, 6-trimethoxyxylene and 2, 4, 6-trimethoxytrimethylbenzene) generated in the methylation process can be detected, and the excessive methylation impurities are prevented from being further transferred and existing in a phloroglucinol trimethyl ether raw material medicine and a final product phloroglucinol injection preparation. Researches on specificity, accuracy, precision, limit of detection, limit of quantitation, linear range, durability and the like of the method prove that the method is suitable for measuring the content of the over-methylated impurities in the phloroglucinol trimethyl ether.

The invention relates to the technical field of tetramethyltin synthesis, in particular to a high-efficiency tetramethyltin synthesis process which comprises the following steps: S1, material selection and preparation: selecting corresponding raw materials according to tetramethyltin synthesis requirements, dividing the raw materials into main materials, auxiliary materials and additives, and subsequently weighing the raw materials by using a weighing device; s2, material pretreatment: adding the weighed main material into a dehydration device, starting the dehydration device to carry out dehydration treatment, detecting after dehydration is finished, and taking out the dehydrated main material when a detection result meets a standard; by introducing the double-stage design of low-temperature catalytic methylation and gradient heating reaction and combining a dimethyl sulfide catalytic system to replace a traditional iodine initiator and magnesium powder dynamic equilibrium mechanism, the reaction heat release rate is greatly reduced, the temperature in the whole reaction process is kept in a constant range, the material flushing or explosion risk caused by local overheating is thoroughly eliminated, and the product quality is improved. And intrinsically safe production is realized.

The invention relates to a preparation method of 1-methyl-5-hydroxypyrazole, which comprises the following steps: (a) methylation reaction: fully dissolving pyrazole in a reaction solvent a, dropwise adding a methylation reagent into the reaction solvent a to carry out methylation reaction, adding water into the reaction solvent a to carry out quenching reaction after the reaction is completed, fully washing and concentrating to generate 1-methylpyrazole; (b) bromination hydrolysis reaction: fully dispersing 1-methylpyrazole in a reaction solvent b, dropwise adding bromine into the reaction solvent b to perform bromination reaction, dropwise adding liquid caustic soda and a sodium thiosulfate solution into the reaction solvent b to perform quenching reaction after the reaction is completed, adding the liquid caustic soda into the reaction solvent b after extraction and concentration, and performing heating hydrolysis and cooling crystallization to obtain the 1-methyl-5-hydroxypyrazole. The preparation method of the 1-methyl-5-hydroxypyrazole is reasonable in design, not only reduces the isomer 1-methyl-3-hydroxypyrazole, but also avoids the use of liquid with pungent smell, such as ethylenediamine, and precursor reagents, such as methylhydrazine, improves the operation safety, is environment-friendly, and is beneficial to industrial production.

This invention belongs to the field of chemical synthesis and relates to a method for achieving deuterated methylation of a nucleophile. The invention provides a deuterated methylating reagent, which is obtained by reacting formic acid with deuterated methanol under acidic conditions, followed by a second reaction with thiaanthracite and trifluoromethanesulfonic acid. The nucleophile is then reacted with the deuterated methylating reagent described in claim 1, a base, and a solvent to obtain the deuterated methylated product. This invention also provides a method for achieving deuterated methylation of a nucleophile, which involves dissolving the nucleophile and 5-deuterated methyl-5H-thiophene-5-onium trifluoromethanesulfonate in a suitable solvent, adding a base, and then performing the deuterated methylation reaction at room temperature. In the method provided by this invention, the yield of the product after nucleophile methylation can reach 52% to 95%.

The invention relates to an L-proline heterocyclic intermediate, alpha-methyl-L-proline hydrochloride and a preparation method thereof, which comprises the following steps: step 01, cyclization upper protection: taking L-proline as a raw material, which is shown in a formula (1), to react with trichloracetic aldehyde hydrate under an acidic condition, and performing upper protection to obtain a heterocyclic intermediate as shown in a formula (2); the molar weight of chloral hydrate is 1-2.5 times of the molar weight of the L-proline shown in the formula (1), preferably 1.5 times of the molar weight of the L-proline shown in the formula (1). 02, methylation: reacting the heterocyclic intermediate as shown in the formula (2) obtained in the step 01 with lithium diisopropylamide, and after the reaction is completed, adding dimethyl sulfate for methylation to obtain an intermediate as shown in a formula (3); 03, deprotection: adding the intermediate as shown in the formula (3) obtained in the step 02 into a deprotection reagent for hydrolysis so as to obtain the alpha-methyl-L-proline hydrochloride as shown in the formula (4), so that the problems that the preparation cost of the existing alpha-methyl-L-proline hydrochloride is relatively high and the yield is relatively low can be solved.

The invention discloses a method and system for comprehensively utilizing a water phase in an aniline methylation reaction product, and the method comprises the following steps: firstly, taking the water phase in the aniline methylation reaction product as a raw material, and rectifying the raw material to obtain a methanol distillate and a mixed solution containing aniline, N-methylaniline, trace N, N-dimethylaniline organic matters and water; a low-boiling-point aromatic hydrocarbon solvent is used as an extraction agent, the obtained mixed solution is used as a raw material, and the raw material and the extraction agent are subjected to multiple times of reverse contact for extraction; standing and layering to obtain an extraction phase and a raffinate phase; wherein the extraction phase is a mixture of an amine organic matter and an extraction agent, and the raffinate phase contains wastewater with the content of the amine organic matter reduced. According to the method, the methanol, the amine mixed organic matters and the extraction agent can be recycled, the content of the organic matters in the water can be remarkably reduced, the water can be discharged after reaching the standard after being subjected to further biochemical treatment, and the resource comprehensive utilization of the water phase solution is realized.

The invention relates to a suzertraline intermediate as well as a preparation method and application thereof, and particularly provides a suzertraline intermediate 3, 4-difluoro-2-methoxyphenylacetic acid compound and a preparation method thereof, and the suzertraline intermediate can be used for preparing 3, 4-difluoro-2-methoxyphenylacetic acid. Specifically, 2, 3, 4-trifluoronitrobenzene which is low in price and easy to obtain serves as a starting raw material, 3, 4-difluoro-2-methoxyphenylacetic acid is prepared through a substitution reaction, a methylation reaction, a reduction reaction, a Meerwein arylation reaction and a hydrolysis reaction, the method is mild in reaction condition, a reaction substrate better meets the economic and environment-friendly requirements, reaction operation and a post-treatment process are safe and simple, and the method is suitable for industrial production. The purification steps are simple and convenient, byproducts are few, a target product with high purity can be obtained conveniently, corrosion to equipment is small, special equipment is not needed, and the method is suitable for industrial production.

The invention belongs to the technical field of synthesis and preparation of high-molecular optical materials, and particularly relates to a multi-mercaptothiol composition as well as a preparation method and application thereof. According to the present invention, the three-step synthesis route of the tetrahydroxymethylation reaction, the thiol precursor introduction and the deprotection is adopted, the reaction conditions are mild, the steps are clear, the yield is high, the complexity of the traditional synthesis route is avoided, the production cost is reduced, and the industrial production is easily achieved. In the aspect of refractive index regulation and control, the compound contains a plurality of sulfur atoms, the coating is endowed with the characteristic of high refractive index, accurate regulation of the refractive index can be realized by adjusting the formula of the composition, the requirements of different optical applications are met, and the application range of the material is widened. The prepared optical coating has excellent light transmittance, light loss can be reduced to the maximum extent, and the efficient performance of an optical device is ensured; meanwhile, the haze value of the coating is low, the light scattering phenomenon is effectively avoided, and the imaging definition and the precision of an optical system are guaranteed.

The invention relates to the technical field of covalent organic framework functional materials, in particular to a pyridine-rich imine type covalent organic framework as well as a preparation method and application thereof. The pyridine-rich imine type covalent organic framework disclosed by the invention has a structure as shown in the following formula (I): # imgabs0 # formula (I). The pyridine-enriched imine type covalent organic framework disclosed by the invention contains rich pyridine-N active sites, can efficiently adsorb iodine through Lewis acid-base action, and can effectively fix iodomethane through methylation reaction, so that two iodine pollutants can be efficiently captured at the same time. The pyridine-rich imine type covalent organic framework disclosed by the invention also has good crystallinity, larger specific surface area and excellent thermal stability and acid-base stability, and can realize efficient adsorption of iodine and iodomethane.

The invention provides a synthesis method of saflufenacil, and belongs to the field of chemical synthesis. The preparation method comprises the following steps: reacting N-(2-chloro-4-fluoro-5-aminobenzoyl)-N '-isopropyl-N'-methyl sulfonamide serving as a raw material with chloroformate in a strong polar solvent, then directly adding alkali and ethyl 3-amino-4, 4, 4-trifluoro-2-butenoate into the reaction material, and carrying out cyclization reaction, so as to obtain the N-(2-chloro-4-fluoro-5-aminobenzoyl)-N '-isopropyl-N'-methyl sulfonamide. And carrying out methylation reaction on the cyclization reaction material and a methylation reagent to obtain saflufenacil. The selected reaction solvent is relatively single and easy to recover, so that the reaction operation is simple, the product yield is improved, and the method is suitable for industrial large-scale production and has a wide application prospect.

The invention provides a method for synthesizing N-methylated polypeptide, which comprises the following steps: dissolving a carboxylic acid compound, N-methyl amino-acid ester hydrochloride or N-methyl amino-acid ester, an alkaline substance and pivaloic anhydride in an organic solvent, reacting at 15-80 DEG C for 3-10 hours, and post-treating the obtained reaction liquid to obtain an N-methyl dipeptide compound, the method comprises the following steps: removing a protecting group in an N-methyl dipeptide compound to obtain a free-state N-methyl dipeptide compound, and condensing the free-state N-methyl dipeptide compound and amino acid or N-methyl amino-acid ester protected by amino to obtain the N-methylated polypeptide, the mixed anhydride intermediate is formed in situ, and the reaction is completed in one step; according to the method, trimethylacetic anhydride is used as a condensing agent, the structure is simple, the reaction is safe, cheap and non-toxic, a large amount of nitrogen-containing byproducts are not generated in the reaction, and purification is convenient; the method is high in stereoselectivity, and racemization is avoided; according to the method, environment-friendly solvents such as ethyl acetate can be used, the reaction condition is mild, and the reaction time is short.

The present application relates to a kind of preparation method of trifluoromethyl pyrazole compound, belong to the technical field of organic synthesis.The specific method is: (1) trifluoroacetyl ethyl acetate is first with hydrazine hydrate cyclization reaction and generates compound of formula III;(2) under the catalysis of base, compound of formula III is reacted with difluoromethylation reagent and generates compound of formula II;(3) compound of formula II is reacted with methylating agent and obtains compound of formula I;The difluoromethylation reagent is difluoro-monochloromethane or sodium difluoro-monochloroacetate;The methylating agent is chloromethane, bromomethane, iodomethane, dimethyl sulfate or dimethyl carbonate.The present application is prepared by changing reaction route, and the higher-priced raw material methylhydrazine is replaced, and isomer impurity is no longer generated in the product prepared.Not only raw material cost is reduced, but also the purity of product is improved.

The invention provides a preparation method of (S)-(+)-1-methoxy-2-propylamine hydrochloride, which comprises the following steps: taking (S)-(+)-2-amino-1-propanol as a raw material, carrying out halogenation reaction and amino protection, then carrying out methylation reaction with methanol, and finally carrying out amino deprotection by using hydrochloric acid to obtain the product (S)-(+)-1-methoxy-2-propylamine hydrochloride. The method is suitable for industrial production.

The invention relates to the technical field of chemical synthesis, and discloses a preparation method and control of an abelsiril impurity A, namely 6-(4-chloro-5-fluoropyrimidine-2-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole. The preparation method comprises the following steps: S1, carrying out aromatic nucleus nucleophilic substitution reaction on a compound I and a nucleophilic reagent in an organic reagent, washing an organic phase, drying, filtering, and drying to obtain a compound II; concentrating under reduced pressure to obtain a compound II; s2, mixing the compound II, the compound III, a palladium catalyst, alkali and an organic solvent, performing heating reflux under the protection of nitrogen, performing Suzuki coupling reaction, performing vacuum concentration, and washing a filter cake with tetrahydrofuran to obtain a compound IV; s3, carrying out demethylation reaction on the compound IV to obtain a compound V; s4, the compound V reacts with a chlorination reagent, reduced pressure distillation is conducted, separation and purification are conducted, and the abelsilib impurity A is obtained. The design route provided by the invention is reasonable, the reaction site selectivity is good, and the impurity A with relatively high purity can be obtained.

The present invention relates to the field of organic chemical synthesis, and specifically relates to a 6-bromonicotine synthesis method. The 6-bromonicotine synthesis method uses 6-hydroxymyosmine (CAS: 70969-38-9) as a starting material, which sequentially undergoes a reduction reaction, an amine methylation reaction and a bromination reaction, to finally obtain the target product 6-bromonicotine. The product purity of the 6-bromonicotine obtained by means of the synthetic route can reach 99.0% or more. The present synthesis method has a simple process and a high yield, and is suitable for industrial scale-up production.

The present invention discloses a polyporus badius polysaccharide and its preparation method and application, belonging to the technical field of polysaccharide extraction. The polyporus badius polysaccharide (PPP-0A) includes galactose, fucose, glucose, mannose and xylose, and the molar ratios are 62.26%, 16.96%, 15.23%, 4.68% and 0.87% respectively. The present invention uses techniques such as methylation, scanning electron microscopy, thermogravimetric analysis, nuclear magnetic resonance and atomic force microscopy to determine the structural characteristics of PPP-0A, analyze its composition and properties, and its inhibitory effects on the activities of α-glucosidase and α-amylase. In addition, an in vitro HepG2 cell model induced by high blood glucose and high insulin levels was used to study the hypoglycemic effect of PPP-0A. The present invention provides a theoretical basis for clarifying the relationship between the hypoglycemic activity of PPP-0A and its hypoglycemic effect on type 2 diabetic mice.

The present invention provides a method for preparing an α-cadaverine-based compound of the following general formula (3): wherein R 2 represents a monovalent hydrocarbon group having 1 to 9 carbon atoms, the method comprising: making a 3,5,5-trimethyl-3-cyclopentene compound of the following general formula (1): wherein R 2 As defined above, and X represents a leaving group, and the methylating agent of the following general formula (2): wherein M represents Li, Mg, Z 1 、ZnZ 1 、Cu、CuZ 1 or CuLiZ 1 , and Z 1 represents a halogen atom or a methyl group, undergoing a nucleophilic substitution reaction to form an α-cadaverine-based compound (3). The present invention also provides a method for preparing a γ-cadaverine-based compound of the following general formula (4): wherein R 2 represents a monovalent hydrocarbon group having 1 to 9 carbon atoms, and the method comprises: subjecting the thus obtained α-cadaverine-based compound (3) to positional isomerization reaction at the double bond to form a γ-cadaverine-based compound (4). #imgabs0#

The invention relates to the technical field of cathode electrophoretic paint, and discloses an asymmetric double-blocked isocyanate curing agent as well as a preparation method and application thereof. Based on the reaction activity difference of primary carbon and secondary carbon NCO groups in isophorone diisocyanate molecules, a step-by-step asymmetric sealing strategy is adopted: in the first stage, a hydrophilic chain extender containing a tertiary amine structure is utilized to preferentially react with high-activity primary carbon NCO, and an internal catalytic center and a hydrophilic group are anchored in a molecular skeleton; and in the second stage, the active methylene compound and the bio-based long-chain phenol are used for carrying out hybrid dual-sealing on the residual secondary carbon NCO with relatively large steric hindrance. According to the preparation of the curing agent, the curing agent integrates internal catalysis, stepped curing and self-emulsifying functions, the deblocking energy barrier is effectively reduced, and 140-DEG C low-temperature curing or high-temperature high-performance curing can be realized under the tin-free catalysis condition.

The invention provides a synthesis method of 1-methyl-L-histidine, which comprises the following steps: firstly, carrying out methylation reaction on a compound 1 and N, N-dimethylformamide dimethyl acetal to obtain a compound 3; the compound 3 and NCS are subjected to a chlorination reaction, and a compound 4 is obtained; then reacting the compound 4 with diethyl acetamidomalonate to obtain a compound 5; then carrying out hydrolysis decarboxylation on the compound 5 to obtain a compound 6; and finally, splitting the compound 6 by using acetyl hydrolase to obtain a chiral compound 7 (namely 1-methyl-L-histidine). The synthesis route is short, the raw materials are cheap, the production cost can be reduced, the product yield and purity are high, and large-scale industrial production is facilitated.

The invention relates to the technical field of biological medicine, in particular to a novel amino acid or polypeptide side chain carbonylation modification reagent which can be used as a novel carbonylation reagent in a method for synthesizing gamma-C (sp3)-H bond carbonylation amino acid or polypeptide through palladium catalysis. Substituting ethylene with a novel carbonylation reagent 1-iodine-2-bromine under the action of a palladium catalyst, an additive and a solvent to realize carbonylation and methylation of the amino acid gamma-C (sp3)-H bond. The method disclosed by the invention has the beneficial effects that a novel carbonylation reagent easy to prepare is developed, substrate raw materials are easy to obtain, the operation is simple and convenient, the condition is mild, the substrate application range is wide, and a plurality of carbonylated amino acids and polypeptide derivatives can be efficiently and accurately synthesized at low cost; and a novel method is provided for modification of unnatural amino acids and polypeptide side chains.

A process for inhibiting polymerization, colloid formation and fouling in an atypical high temperature ethylene fractionation system, the process comprising treating the atypical high temperature ethylene fractionation system with a composition comprising an effective amount of one or more quinone methide of formula (I), wherein R1, R2 and R3 are independently selected from the group consisting of H,-OH,-SH,-NH2, alkyl, cycloalkyl, heterocycle and aryl; or one or more phenylenediamine, optionally in combination with one or more hindered phenols. # imgabs0 #

The invention belongs to the field of electrochemical synthesis, and particularly discloses a method for synthesizing N, N, N ', N'-tetramethyl methylenediamine by directly utilizing a dimethylamine aqueous solution through electrochemical amine methylenation. According to the method, a dimethylamine aqueous solution is used as a raw material, and an electrochemical amine methyleneation reaction of dimethylamine is carried out on an anode loaded with a carbon material catalyst in an electrically driven oxidation manner, so that synthesis of N, N, N ', N'-tetramethyl methylenediamine is realized. Different from the existing dimethylamine and formaldehyde condensation method and dimethylamine and methanol electrosynthesis method, the method disclosed by the invention directly adopts the industrial dimethylamine aqueous solution as a raw material to synthesize N, N, N ', N'-tetramethyl methylenediamine, so that the process flow is simplified, and the yield is high. The method has the characteristics of mild process conditions, high system stability, few byproducts, greenness, safety, low cost and suitability for industrial application. The method has wide application potential in the fields of electrochemical organic synthesis, energy storage, pharmaceutical chemical industry and the like.

The invention discloses a liver tissue regeneration regulation and control method based on epigenetic state regulation and control, and relates to the technical field of biology. Comprising the following steps: sampling the liver tissue at a plurality of preset time points after the liver tissue is damaged or partially resected, selecting a target gene related to liver tissue regeneration regulation, and detecting an epigenetic state of a promoter region of the target gene; comparing and analyzing the change of the epigenetic state of the target gene promoter region on the basis of detection results obtained at different time points, and determining epigenetic modification characteristics in the liver tissue regeneration process; according to an analysis result, intervening the expression level of a regulatory factor related to DNA methylation or DNA hydroxymethylation so as to regulate the epigenetic state of the target gene promoter region; after intervention is completed, the transcription expression condition of a target gene and the activity change of a cell signal channel related to liver tissue regeneration are detected, and the liver tissue regeneration process can be effectively regulated and controlled through the method.

The invention relates to a method for producing mecobalamin by using a micro-channel reactor, which comprises the following steps: firstly, introducing a reaction mixed solution of cyanocobalamin, cobalt chloride, sodium borohydride and purified water into a first micro-channel reactor for reduction reaction; the obtained cyanocobalamin solution in the reduction state is introduced into a second microchannel reactor to be subjected to a methylation reaction with a trimethylsulfoxide iodide solution, and finally, an obtained mecobalamin solution is subjected to post-treatment to obtain a finished product. Compared with the prior art, the micro-channel reactor is used for continuous production, the mass and heat transfer effect is good, the reaction temperature can be accurately controlled, side reactions are further reduced, and the product quality is effectively improved.

The invention discloses an alpha-dideuterium methylated sulfone compound as well as a synthesis method and application thereof, and belongs to the field of organic chemistry. In an air atmosphere, benzyl methyl sulfone and 2-((3, 5-dimethyl-4-methoxypyridine-2-yl) methylsulfonyl)-5-methoxy-1H-benzo [d] imidazole are used as substrates, in the presence of a catalyst [Cp * IrCl2] 2 and cesium carbonate, deuterated paraformaldehyde is used as a carbon source, sodium formate is used as an additive, and the alpha-dideuterium methylated sulfone compound is obtained through a reaction in an acetonitrile solvent at 120 DEG C. The reaction does not need to use a ligand and hydrogen, the reaction is simple and efficient, the potential value of the compound in medicinal chemistry is shown, and the compound has a certain inhibition effect on H3N2 subtype influenza viruses and has remarkable application potential.

The invention discloses a preparation method of an azacyclo-bis (fluorosulfonyl) imide salt derivative, which comprises the following steps of: 1, mixing an azacyclo-compound, a methylation reagent, an ethylation reagent, bis (fluorosulfonyl) imide salt and inorganic alkali in a polar organic solvent, heating, and filtering after complete reaction to obtain crude filtrate containing the azacyclo-bis (fluorosulfonyl) imide salt; the nitrogen heterocyclic compound is selected from one of oxazolidine, 4-cyano piperidine, 4-fluoro piperidine, 4, 4-difluoro piperidine and 3-cyano piperidine; the bis (fluorosulfonyl) imide salt is selected from one of lithium bis (fluorosulfonyl) imide and potassium bis (fluorosulfonyl) imide; and 2, adding an inert organic solvent into the crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product. The method has the advantages that the operation steps are few, the synthesis efficiency is greatly high, the process is greatly simplified, and the preparation cost is effectively reduced.