Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of fructus forsythiae aglycone in preparing medicament for preventing or treating liver injury or liver failure

A technology for forsythiaglycoside and liver damage, applied in the field of medicine, can solve the problems of life-threatening and weak targeted drug administration, achieve low toxic and side effects of the human body, improve drug safety and drug compliance, and improve treatment effect and quality of life effects

Inactive Publication Date: 2014-08-20
LUNAN PHARMA GROUP CORPORATION
View PDF2 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With the rapid development of medical technology, although there have been many studies and reports on drugs for the treatment of liver damage, some studies have shown that some anti-liver damage drugs will inevitably produce biological toxicity, which is dangerous to life, and targeted drug delivery not strong

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of fructus forsythiae aglycone in preparing medicament for preventing or treating liver injury or liver failure
  • Application of fructus forsythiae aglycone in preparing medicament for preventing or treating liver injury or liver failure
  • Application of fructus forsythiae aglycone in preparing medicament for preventing or treating liver injury or liver failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Forsythiagenin Injection

[0024]

[0025] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add forsythiagenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain .

Embodiment 2

[0026] Example 2 Forsythiagenin Injection

[0027]

[0028] Preparation process: add forsythiagenin to the prescribed amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 3

[0029] Example 3 Forsythiagenin Injection

[0030]

[0031] Preparation process: mix the prescribed amount of ethanol and Tween-80 evenly, add forsythinin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of fructus forsythiae aglycone in preparing a medicament for preventing or treating liver injury or liver failure, and belongs to the medical field. The fructus forsythiae aglycone is a traditional Chinese medicine monomer obtained by extracting from the conventional fructus forsythiae, and is shown to have better treatment effect for the liver injury caused by acetaminopben, the livery injury caused by anti-tumor drug cis-platinum, acute or chronic livery injury caused by carbon tetrachloride, the livery injury caused by D-galactosamine and the liver failure caused by the D-galactosamine and lipopolysaccharide according to an animal test, has effect, which is better than that of fructus forsythiae and fructus forsythiae aglycone, in treating liver injury or liver failure. The fructus forsythiae aglycone is exact in curative effect and low in side effect for treating the liver injury and the liver failure, and has wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical application of forsythiagenin, in particular to the medical application of forsythiagenin in the preparation of medicines for preventing or treating liver damage or liver failure. Background technique [0002] As the most important detoxification organ, the liver is an important target of many drugs and exogenous chemicals. Liver injury is the result of various liver diseases, and it is the initiating link and common path for the occurrence, development and eventual hepatic failure of many serious liver diseases. Among them, chemical liver injury, immune liver injury and physical liver injury Various liver injuries such as liver disease are serious frequently-occurring common diseases in my country at present. The pathogenesis of liver injury is very complex, which is the result of multi-factors, multi-layers, and multi-targets, mainly caused by drugs, alcohol, organisms, viruse...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/34A61P1/16
Inventor 赵志全姚景春冯芹刘艳松胡海勋王现珍
Owner LUNAN PHARMA GROUP CORPORATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com