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Method for preparing compound paracetamol and amantadine hydrochloride tablet

A technology for acetaminophen and amantadine hydrochloride, which is applied in pharmaceutical formulas, active ingredients of amines, medical preparations containing active ingredients, etc., and can solve the problem that excipients are not allowed to be replaced casually

Inactive Publication Date: 2012-06-13
吉林省吴太感康药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the relevant provisions of the "Drug Administration Law" and GMP, the excipients in the drug prescription are not allowed to be replaced casually. Therefore, it is theoretically possible to add some special excipients to meet the requirements of increasing the dissolution rate and the stability of the finished product, but not directly used in production

Method used

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  • Method for preparing compound paracetamol and amantadine hydrochloride tablet
  • Method for preparing compound paracetamol and amantadine hydrochloride tablet
  • Method for preparing compound paracetamol and amantadine hydrochloride tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take an appropriate amount of acetaminophen, carry out 450-mesh ultrafine grinding, weigh 20g, and set aside; weigh 230g of acetaminophen after crushing through a 100-mesh sieve, 100g of amantadine hydrochloride, 15g of caffeine, and sucrose Powder 20g, and prescription amount of artificial bezoar and chlorpheniramine maleate are added to the high-efficiency wet mixing granulator, granulated with 12% starch slurry, boiled and dried, granulated, and 5g of magnesium stearate is added , mixed uniformly, compressed into tablets, printed, packaged, inspected, and finally obtained, and 1000 pieces of compound acetaminophen tablets were prepared.

Embodiment 2

[0042] Take an appropriate amount of acetaminophen, carry out 300-mesh ultrafine grinding, weigh 100g, and set aside; weigh 150g of acetaminophen, 100g of amantadine hydrochloride, 15g of caffeine, and sucrose after crushing through a 100-mesh sieve according to the prescription amount. Powder 20g, and prescription amount of artificial bezoar and chlorpheniramine maleate are added to the high-efficiency wet mixing granulator, granulated with 12% starch slurry, boiled and dried, granulated, and 5g of magnesium stearate is added , mixed uniformly, compressed into tablets, printed, packaged, inspected, and finally obtained, and 1000 pieces of compound acetaminophen tablets were prepared.

Embodiment 3

[0044] Take an appropriate amount of acetaminophen, carry out 350-mesh ultrafine grinding, weigh 70g, and set aside; weigh 180g of acetaminophen after crushing through a 100-mesh sieve, 100g of amantadine hydrochloride, 15g of caffeine, and sucrose Powder 20g, and prescription amount of artificial bezoar and chlorpheniramine maleate are added to the high-efficiency wet mixing granulator, granulated with 12% starch slurry, boiled and dried, granulated, and 5g of magnesium stearate is added , mixed uniformly, compressed into tablets, printed, packaged, inspected, and finally obtained, and 1000 pieces of compound acetaminophen tablets were prepared.

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Abstract

The invention particularly relates to a method for preparing a compound paracetamol and amantadine hydrochloride tablet, which belongs to the field of medicines. According to the method, submicron powder and ordinary fine powder which has been sieved with a 100-mesh sieve are mixed in proportion, a proper amount of accessories are added, and a prepared finished product is enabled to have better dissolvability, more than 90% on average. After six-month accelerated normal temperature stability experiments, the dissolvability of the finished product prepared by using the method is about 90%, and all the other indexes of the finished product accord with quality standard requirements.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a method for preparing compound acetaminophen tablets. Background technique [0002] Flu is a self-healing disease, which is generally divided into common cold and influenza. The common cold, called "cold" by traditional Chinese medicine, is a common respiratory disease caused by a variety of viruses, 30%-50% of which are caused by a certain serotype of rhinovirus. Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonals is not just the same yet. Influenza is an acute respiratory infectious disease caused by influenza virus. Virus is present in patient's respiratory tract, gives others through droplet infection when patient's cough, sneeze. [0003] Gankang (Compound Amphenamine Tablets) is one of the cold medicines that are widely favored by patients in the market. According to the survey d...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/20A61P11/00A61P31/14A61P31/16A61K31/13A61K31/167A61K31/4402A61K31/522
Inventor 吴元芬邢福涛
Owner 吉林省吴太感康药业有限公司
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