Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Electrochemical paracetamol molecular imprinting transducer and manufacturing method thereof

A technology of paracetamol and molecular imprinting, applied in the direction of material electrochemical variables, etc., can solve the problems of difficult elution of template molecules, limitation of polymer pore size, easy swelling and damage of imprinted holes in polymers, etc.

Inactive Publication Date: 2012-10-17
GUANGXI UNIV FOR NATITIES
View PDF0 Cites 26 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these small-molecule cross-linking agents have some disadvantages, such as the poor rigidity of molecularly imprinted polymers, the imprinted holes of polymers are easy to swell and destroy, and the elution of template molecules is difficult, so a large amount of cross-linking agents needs to be added, which limits Polymer Pore Size

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Electrochemical paracetamol molecular imprinting transducer and manufacturing method thereof
  • Electrochemical paracetamol molecular imprinting transducer and manufacturing method thereof
  • Electrochemical paracetamol molecular imprinting transducer and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Treatment of glassy carbon electrodes

[0019] Polish the glassy carbon electrode on the buckskin with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 and sonicate for 5 minutes, then put it into absolute ethanol for 5 minutes, and finally Ultrasonic cleaning with ultrapure water.

[0020] 2. Preparation of molecularly imprinted electrochemical sensor for paracetamol

[0021] To 2.0ml solvent acetonitrile, add 0.2mmol template molecule paracetamol, 0.8mmol functional monomer acrylamide, 0.8mmol crosslinking agent maleic rosin ethylene glycol acrylate and 0.08mmol initiator azobisisobutyronitrile , every time a chemical reagent is added, ultrasonically dissolve for 5 minutes;

[0022] After the mixture is dissolved, take 2 μL of the mixture in step and apply it on the surface of the treated clean and smooth glassy carbon electrode. After standing for half an hour, place the modified electrode in a vac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an electrochemical paracetamol molecular imprinting transducer and a manufacturing method thereof. According to the transducer, a molecular imprinting technology and an electric analysis and chemical detection technology are combined. Paracetamol is taked as a template molecule, acrylamide is taken as a functional monomer, special resource rosin of Guangx is combined with paracetamol and acrylamide, and maleated rosin ethylene glycol dimethacrylate compounded by the rosin serving as a raw material is used as a cross-linking agent. The electrochemical paracetamol molecular imprinting transducer can be used for measuring the content of paracetamol, and has favorable selecting recognition performance. The electrochemical analysis method for detecting the paracetamol, which is provided by the invention, is simple and practical, and meanwhile, can be used for overcoming the defect of the complexity of the traditional method.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a paracetamol molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Paracetamol has antipyretic and analgesic effects, and can be used for cold and fever, joint pain, neuralgia, migraine, cancer pain and post-operative pain relief. Overdose of paracetamol can cause severe liver damage, and even acute poisoning can lead to liver necrosis and death within a few days. Long-term use of paracetamol can also lead to drug dependence, and the accumulation of drug doses has also become a major risk factor for non-hereditary and non-environmental asthma. Therefore, it is of great significance to study a highly selective detection method for paracetamol. [0003] Molecular imprinting technology uses the target molecule to be tested as a template molecule, combining structurally complementary functional monomers with th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30
Inventor 谭学才孙月新余会成黄在银刘绍刚雷福厚
Owner GUANGXI UNIV FOR NATITIES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com