9 results about "Sodium Alginate Microspheres" patented technology

The application discloses a construction method of a 3D printing liver organoid support loaded with mesenchymal stem cells assembled by FH1 sodium alginate microspheres, and comprises the following steps: preparing CaO2@ZIF-8@SL; preparing FH1-loaded sodium alginate microspheres FH1@SA; and preparing a 3D printing liver organoid support. The 3D printing liver organoid support prepared by the method can significantly enhance the differentiation of human umbilical cord mesenchymal stem cells into functional stem cells, and can be used for constructing a human liver organoid model.

The application discloses a drug-loaded microalgae motor system for colon-targeted delivery and a preparation method and application thereof. The drug-loaded microalgae motor system comprises a Chlamydomonas reinhardtii microalgae motor core, the surface of the core is adsorbed with amino-modified ferroferric oxide nanoparticles through electrostatic adsorption, is wrapped with quercetin-modified chitosan quaternary ammonium salt, forms a nano-composite with magnetic responsiveness, and is encapsulated in a sodium alginate microsphere. The application utilizes Chlamydomonas reinhardtii as an antioxidant for adjuvant therapy, in a colon environment, the sodium alginate microsphere can be degraded in response to specific conditions, release the microalgae motor to autonomously move in intestinal fluid, and under the guidance of an external magnetic field, precisely target a lesion site in the intestinal tract. The application has good biocompatibility, biodegradability, gastric acid avoidance ability and magnetic / chemical dual driving targeting function, can effectively improve the treatment effect on colon diseases, and significantly reduce the systemic side effects of drugs, and expands the application of micro / nano motors in the biomedical field.

The application discloses a pH response type coating agent and application thereof in seed germination of alkali grass. The application comprises the following steps: pretreating alkali grass seeds with a mixed salt alkali solution with a specific ratio, coating the seeds with a double-layer coating agent composed of an outer layer of dimethylaminoethyl methacrylate-acrylic acid copolymer and an inner layer of sodium alginate microspheres loaded with Bacillus subtilis GB03, and culturing the seeds under alternating light and darkness and variable temperature conditions; when the environmental pH reaches a critical value, the coating agent precisely swells and ruptures to release live bacteria, and the salt alkali solution activates the bacteria, thereby significantly improving the seed germination rate of the alkali grass and effectively solving the technical problem of low seed germination rate in the reconstruction of vegetation in saline-alkali soil. The method for efficiently germinating alkali grass is simple and easy to implement, and does not require complex operations, and can quickly and effectively improve the seed germination rate of the alkali grass. The method can be applied to production, thereby solving the problem of low seed germination rate of the alkali grass in the production process, and has important significance for the construction of artificial grassland of the alkali grass.

The application provides a kind of targeted self-driven nanomotor hydrogel and its preparation method and application, belong to the field of biological medicine. Including the following steps: Janus mesoporous silica platinum nanomotor is synthesized by Pickering emulsion method, first loaded liraglutide by amination reaction, then grafted rapeseed DPP-IV inhibiting peptide by amide method, and encapsulated in sodium alginate microspheres, to obtain self-driven nanomotor hydrogel. The self-driven nanomotor described in the application can actively overcome the intestinal mucus barrier, pass through the mucus barrier into the specific site by autonomous navigation, significantly enhance the drug efficiency, avoid degradation in harsh stomach environment, reverse insulin resistance, reduce inflammatory complications such as diabetes, and enhance the safety and bioavailability of drugs.

This invention discloses a recombinant type III collagen composite cosmetic injectable filler, comprising the following raw materials in parts by weight: 0.5-1 parts sodium hyaluronate, 0.1-0.2 parts recombinant type III humanized collagen, 0.02-0.05 parts genipin, 0.03-0.08 parts catechin-oxidized sodium alginate microspheres, 0.01-0.03 parts bacterial cellulose, and 100 parts physiological saline. This invention also discloses a method for preparing the aforementioned recombinant type III collagen composite cosmetic injectable filler. The composite cosmetic injectable filler of this invention not only has excellent filling and repair effects but also maintains the filling effect for a long time, making it a very promising cosmetic repair material.

This invention provides a method for preparing functionalized UiO-66 / sodium alginate microspheres, specifically including the following steps: Step 1, preparing functionalized UiO-66 powder; Step 2, preparing functionalized UiO-66 / sodium alginate microspheres using the functionalized UiO-66 powder; Step 1 specifically includes the following steps: Step 11, adding a certain amount of zirconium chloride and terephthalic acid to a certain amount of N,N-dimethylformamide; Step 12, adding a certain amount of hydrochloric acid, a certain amount of acetic acid, and a certain amount of 2-hydroxyphosphonoethyl acetate to the solution of Step 11. Acid is stirred in a constant temperature water bath for a period of time; Step 13: The solution obtained in Step 12 is transferred to a reaction vessel, and then the reaction vessel is placed in an oven at a certain temperature for a period of time; Step 14: After the reaction vessel cools down, the liquid in the reaction vessel is transferred from the reaction vessel to a centrifuge tube and centrifuged to obtain a white powder; Step 15: The white powder is washed alternately with N,N-dimethylformamide and methanol a certain number of times; Step 16: The washed white powder is placed in an oven at a certain temperature for a period of time to dry, thereby obtaining functionalized UiO-66 powder.

This invention discloses an AB-type bimicrosphere powder capable of in-situ liquid absorption and self-assembly, as well as its preparation and application. The preparation method includes: preparing photocrosslinkable hydroxypropyl chitosan and photocrosslinkable oxidized sodium alginate, respectively; using microfluidic technology and ultraviolet light curing to obtain chitosan microspheres loaded with polyphenols and antibacterial agents, and sodium alginate microspheres, respectively; and adsorbing Fe2+ onto the sodium alginate microspheres. 2+ Two types of microspheres were freeze-dried into powder and then mixed in a specific ratio to obtain AB-type dual microsphere powder capable of in-situ liquid absorption and self-assembly. This invention utilizes microfluidic shearing and freeze-drying processes, combined with the synergistic effect of borate ester bonds and carbon-carbon double bonds, to simultaneously achieve the construction of a microsphere cross-linking network and the interaction of polyphenols and Fe. 2+ The loading allows the AB-type bimicrosphere powder, which can absorb liquid in situ and self-assemble, to rapidly absorb liquid upon contact with blood or body fluids and then self-assemble in situ through a Schiff base and a metal-polyphenol network, thereby constructing a stable microsphere scaffold.

This invention relates to the preparation of an iron-copper-sodium alginate composite microsphere and its application in activating periodate to inactivate bacteria and degrade pollutants. The microspheres utilize sodium alginate as a three-dimensional network framework, forming a stable gel structure through ionic cross-linking. A bimetallic active component composed of zero-valent iron and trace amounts of copper is uniformly dispersed within the microspheres. This process activates periodate to achieve highly efficient removal of antibiotic-resistant bacteria, resistance genes, and new pollutants from water. The iron-copper-sodium alginate microspheres are prepared via ionic cross-linking. They are highly efficient and broad-spectrum, achieving rapid sterilization through iron-copper synergy at low metal loading. They are environmentally friendly, as the solid microspheres are completely recyclable, reducing secondary pollution. They are also low-cost, being primarily iron-based with trace amounts of copper for synergistic effects, and reusable. Therefore, this invention provides a novel technical solution for bacterial inactivation and resistance gene removal in water, possessing significant theoretical importance and application prospects.