93 results about "Sodium Alginate Microspheres" patented technology

The invention relates to a tea polyphenol sodium alginate microsphere and a preparation method and an application thereof, in particular to a novel tea polyphenol sodium alginate microsphere. The microsphere is prepared from the following components in parts by weight: 4-6 parts of sodium alginate, 1-2 parts of chitosan, 1-2 parts of porous silicon dioxide and 3-6 parts of tea polyphenols. The porous silicon dioxide is added into a tea polyphenol microsphere, so that the content of tea polyphenols in the microphone can be increased remarkably. The preparation method of the tea polyphenol microsphere includes a liquid dripping one-step method and a liquid dripping two-step method. The microsphere disclosed by the invention can be widely applied in various fields of health-care products and biological medicine, and can be used for reducing blood fat, treating adiposity, removing free radicals in an anti-oxidation way, and preventing and treating tumors.

The invention discloses a preparation method and application of sodium alginate microspheres. After reeds are washed, dried in air and crushed, reed powder is placed in a 600 DEG C muffle furnace (the environment is full of N2) to be subjected to pyrolysis for 2 h, after being cooled, the reed power is sieved through a 100-mesh sieve, and reed biochar is obtained after the reed powder is subjected to chlorohydric acid pickling. Meanwhile, sodium alginate is dissolved in deionized water to be prepared into a 4% sodium alginate solution. A 20g/L reed biochar aqueous solution and the sodium alginate solution are evenly mixed according to the volume ratio of 1:1, a mixed solution is dropped into a CaCl2 solution through a peristaltic pump, and reed biochar-sodium alginate microsphere adsorption materials are made. The sodium alginate microspheres are environment-friendly materials and low in cost, the preparation method is simple and easy to implement, specifications are uniform, the sodium alginate microspheres have a good adsorption effect on pentachlorophenol (PCP) and phenanthrene (Phe) and are easy to recycle and high in acid and alkali resistance. The preparation method can be used for waste water treatment and can also be used as growing carriers of microorganisms, algae and the like.

The invention relates to a temperature-sensitive in-situ gel preparation composition for intra-articular injection and a preparation method thereof, and belongs to the field of medicine preparations. The preparation method comprises the following steps: preparing diclofenac sodium-carrying sodium alginate microspheres by combining a microsphere technology with a temperature-sensitive gel technology, and then carrying the medicine-carrying microspheres in a chitosan/beta-sodium glycerophosphate temperature-sensitive in-situ gel system to obtain a diclofenac sodium in-situ gel preparation composition. The composition is in a liquid state at a room temperature, capable of being converted to a semi-solid gel at a body temperature and forming a medicine storeroom at a medication part after being partially injected to enter an articular cavity, and beneficial to slowly releasing the medicine, prolonging the time of staying at the injection part, of the medicine, and enhancing the efficacy. The composition disclosed by the invention can be used for treating arthritis diseases of rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and the like, as well as applicable to both diclofenac sodium and other arthritis treatment medicines of non-steroidal anti-inflammatory medicines, steroid hormone medicines, biological preparations and the like.

The invention provides a displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent and a preparation method thereof, and relates to a blood vessel embolic agent and a preparation method thereof. An object of the invention is to solve the technical problems that a conventional drug-loaded sodium alginate microsphere blood vessel embolic agent has no X-ray visibility. The method comprises the steps of mixing a sodium alginate solution containing nano silver particles and an antineoplastic drug solution, mixing the above mixture with a solidifying liquid via a dropping method, and thus the displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent is obtained. The displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent has good visibility under X rays, is convenient for observing embolic degree, effectively prevents mistaken embolism, and at the same time, facilitates follow-up observation.

The invention provides a sodium alginate polymer which is generated by carrying out a polymerization reaction, which is initiated by free radicals, to sodium alginate with a monomer which contains anunsaturated double bond and an anionic group, and optionally, a crosslinking agent being poly-functionality water-soluble acrylate or acrylamide. Compared with a sodium alginate microsphere embolic agent on market, the sodium alginate polymer, being a carrier, can adsorb and carry a drug in vitro through ions, wherein the sodium alginate polymer is high in drug carrying capacity and can slowly release the drug in vivo, thus increasing local medicine concentration, prolonging action time of the drug, reducing systemic toxicity of the drug and further improving curative effect of the chemotherapy of the embolism. The invention also provides a novel sodium alginate blood vessel embolism chemotherapy composition, in which the sodium alginate polymer, as the embolic agent and medicine, can be co-delivered to a target blood vessel via a catheter, so that the curative effect of the chemotherapy medicine is fully achieved. The product is free of damage on surrounding normal tissue and can reduce relapse of the diseases.

The invention provides a preparation method for medicine-carrying polypyrrole/sodium alginate gel. The method comprises the following steps: by taking a natural high polymer sodium alginate as a structural guiding agent, forming a monomer compound by virtue of electrostatic attraction between carboxyl in a sodium alginate molecular structure and an amino in a pyrrole monomer; preparing polypyrrole/sodium alginate microspheres through in-situ oxidative polymerization; and then forming the medicine-carrying polypyrrole/sodium alginate gel by virtue of rapid ion exchange reaction between the sodium alginate and calcium ions. The medicine-carrying polypyrrole/sodium alginate gel obtained by the method has excellent double response performances of pH and electric field.

The invention provides a preparation method of calcium alginate microspheres with a core-shell structure, and relates to a preparation method of polymer microspheres. The preparation method comprises the steps that firstly, 100 parts of a polyvinyl alcohol solution (10%) and 10-100 parts of a sodium alginate solution (0.1%-10%) are mixed to prepare a uniform mixed solution; secondly, 1-200 parts of load materials are stirred and added into the mixed solution until a uniform mixture is prepared; thirdly, the mixture is continuously and dropwise added into a borax aqueous solution with the concentration of 0.1%-10%, and microspheres with the diameter of 0.4-4 mm can be formed; finally, the microspheres are taken out to be added into a calcium chloride solution with the concentration of 1%-10% under the stirring condition, so that calcium alginate wrapping layers can be formed on the surfaces of the microspheres, and then the calcium alginate microspheres with the core-shell structure can be obtained. According to the preparation method, the calcium alginate microspheres with the core-shell structure and the good permeability, gelling property and biocompatibility are prepared, have the mechanical strength and are suitable for fields of industry, agriculture, biology, medical science and the like.

The invention discloses a preparation method for embedded nano material/quorum quenching enzyme composite spherules. The preparation method comprises the following steps: embedding embedded nano material/quorum quenching enzyme particles into a sodium alginate solution, thereby preparing sodium alginate microspheres; and coating a high polymer casting film solution added with graphene oxide, and preparing hydrogel composite spherules with organic shell and hydrogel kernel structures by use of a phase inversion method. The composite spherules are capable of inhibiting growth of a membrane-surface biological membrane by use of the bacterial signal molecule degrading function of a quenching enzyme; meanwhile, by use of the aperture, mechanical strength and antipollution characteristics of polymer shells, the erosion endurance and service lives of the composite spherules in MBR are enhanced, the spherule recovery rate is improved, and environmental pollution of nanophase materials is avoided. The embedded nano material/quorum quenching enzyme composite spherules can be widely applied to fields of biology, water treatment and the like.

The invention discloses a method for preparing pharmaceutical dextran and levulose by bi-enzyme immobilization coupled multistage membrane separation, which comprises the following steps: co-immobilizing dextran sucrase and dextranase in sodium alginate microspheres to obtain bi-enzyme-immobilized spheres; adding the bi-enzyme-immobilized spheres into a sucrose solution used as a substrate to form an immobilized bi-enzyme/sucrose reaction system; and after the reaction product is separated by a multistage membrane system composed of hyperfiltration membranes and a nanofiltration membranes, directly obtaining the pharmaceutical dextran in the hyperfiltration membrane separation stage, and obtaining the high-purity levulose solution in the last nanofiltration membrane separation stage, wherein the enzymes and macromolecular dextran contained in the trapped solution of the first-stage hyperfiltration membrane return to the immobilized bi-enzyme/sucrose reaction system to participate in the reaction again, thereby implementing cyclic utilization of the enzymes. The invention has the advantages of lower cost, environment friendliness, high safety and high efficiency, is simple to operate, implements oriented adjustable production of high-quality pharmaceutical dextran with target molecular weight, and obtains the high-purity high-added-value levulose byproduct.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention relates to polyvinyl alcohol hydrogel as well as a preparation method and application thereof and belongs to the technical field of high molecular hydrogel. The preparation method comprises the following steps of: dropwise adding oridonin into a sodium alginate microsphere solution; performing treating to obtain an oridonin/sodium alginate microsphere compound; carrying out EDC/NHS (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide) activation reaction to prepare a polyethylenimine derivative carrier for loading micro RNA (Ribonucleic Acid); finally, uniformly mixing the oridonin/sodium alginate microsphere compound and a micro RNA/polyethylenimine derivative carrier with a polyvinyl alcohol solution and repeatedly freezing and thawing to form ahydrogel material. According to the polyvinyl alcohol hydrogel, the oridonin/sodium alginate microsphere compound and the micro RNA/polyethylenimine derivative carrier loaded on the hydrogel have drug slow release and micro RNA regulation and control functions; the medicinal availability of the oridonin can be improved; the polyvinyl alcohol hydrogel has a gene treatment effect and can be appliedto skin wound dressing.

The invention discloses a hyperbranched polyamide modified sodium alginate microsphere for heavy metal ion adsorption and a preparation method thereof. The preparation method comprises the following steps: (1) adding a sodium alginate solution to a CaCl2 solution dropwise, stirring while adding and conducting crosslinking reaction; filtering and cleaning after the reaction is finished to obtain asodium alginate microsphere; (2) adding the sodium alginate microsphere to a glutaraldehyde solution, then adding hydrochloric acid to carry out aldehyde reaction and filtering and cleaning to obtainthe sodium alginate microsphere containing aldehyde groups on the surface; (3) adding the sodium alginate microsphere containing the aldehyde groups on the surface into a hyperbranched polyamide solution and filtering, cleaning and drying after the reaction to obtain the hyperbranched polyamide modified sodium alginate microsphere. According to the preparation method, a strategy of first balling of the sodium alginate and then grafting is adopted, so that the grafting groups can be completely exposed on the surface of the microsphere, and the utilization rate of the grafting groups is effectively increased.

The invention relates to a method for preparing phosphate-solubilizing microorganism sustained-release sodium alginate microspheres by using an acute hole method. The method includes, firstly, screening, enriching and domesticating to obtain a target phosphorus-solubilizing microbial flora; then mixing the target phosphorus-solubilizing microbial flora with a sodium alginate solution with a certain concentration to obtain a mixed bacterial solution; adding a proper amount of hole-forming agents into the mixed bacterial solution; dripping the mixed bacterial solution into a CaCl2 solution through pinholes with different hole diameters to form the microspheres; and finally, optionally, dispersing the obtained microspheres into a chitosan solution again to obtain the secondary-coated microbial sustained-release sodium alginate microspheres. The microspheres are smaller in particle size and more regular in shape, double coating makes the microspheres have better strength and less easy to crack; and the microspheres have the advantages of good slow release effect, long duration and the like. As the coating materials used are sodium alginate and chitosan which have good biocompatibilityand can be naturally degraded, so that pollution and damage to soil can not be caused.

The invention relates to injectable cartilage repairing hydrogel and a preparation method thereof and belongs to the technical field of biochemical engineering. The injectable cartilage repairing hydrogel with a long-lasting slow-release growth factor is successfully prepared from materials such as aminated chondroitin sulfate, oxidized dextran and a sealing growth factor, namely sodium alginate microspheres. With the adoption of the sodium alginate microspheres in the hydrogel, long-lasting slow release of the growth factor is achieved; in addition, the aminated chondroitin sulfate and the oxidized dextran form the hydrogel through a Schiff base reaction, so that the purpose of injection of the hydrogel can be achieved, and convenience can be brought to clinical operation. The injectablecartilage repairing hydrogel provided by the invention has good biocompatibility and a cartilage induction repairing capability, and has a remarkable promotion function on regeneration of damaged cartilage tissue.

The invention provides a treatment method of printing and dyeing wastewater by combined adsorption, flocculation and membrane separation. The method comprises the following steps: firstly, separatelypreparing quaternized chitosan and sodium alginate microspheres, adding the quaternized chitosan and the sodium alginate microspheres into deionized water, and then dropwise adding a glutaraldehyde solution to carry out a cross-linking reaction to prepare a composite flocculant; preparing a zirconium oxide filter membrane by adopting a sol-gel method, then carrying out silanization treatment on the zirconium oxide filter membrane, and preparing a layer of yttrium-doped titanium oxide on the surface of the zirconium oxide filter membrane to form a composite nanofiltration membrane; and firstlycarrying out adsorption treatment on printing and dyeing wastewater by activated carbon, then adding the prepared composite flocculant into the treated wastewater for precipitation treatment, and finally carrying out nanofiltration treatment on the supernate subjected to flocculation treatment by the nanofiltration membrane, wherein the treated wastewater meets emission requirements. According tothe method, the method of combined adsorption, flocculation and membrane separation is adopted to treat the printing and dyeing wastewater, so that the removal rate of pollutants is high, pollution ofthe membrane in the treatment process is small, and the prepared nanofiltration membrane is excellent in mechanical property.

The invention provides a novel disease-resistant stress-resistant early senescence prevention fertilizer for adjusting crop growth. The novel disease-resistant stress-resistant early senescence prevention fertilizer for adjusting the crop growth is prepared from, by weight, 100 parts of urea, 60-80 parts of monopotassium phosphate, 5-15 parts of fulvic acid chelate microelement, 5-20 parts of diethyl aminoethyl hexanoate, 1-10 parts of 5-nitroguaiacol sodium salt and 5-20 parts of modified chitosan-kelp micro gelation.

The invention provides a multifunctional water-based surface treating agent for microfiber leather and a preparation method of the multifunctional water-based surface treating agent. The multifunctional water-based surface treating agent is prepared from the following components in parts by weight: 30-50 parts of water-based polycarbonate resin, 5-10 parts of sodium alginate microsphere emulsion,6-12 parts of modified polyurethane fluff powder dispersion liquid, 0.5-1.5 parts of a cross-linking agent, and 100-150 parts of water in an evenly-mixing mode. During using, the multifunctional water-based surface treating agent is coated on the surface of the microfiber leather in a rolled mode, the coating amount is controlled to be 15-45 g/m<2>, the drying temperature is 100-130 DEG C, and thedrying time is 2-5 minutes, and after the microfiber leather is cooled, the surface of the microfiber leather can have good extinction feeling, smooth feeling, velvet feeling, leather feeling and hydrophobicity. The multifunctional water-based surface treating agent is prepared by adopting a multiple modification compounding technology, the surface of the microfiber leather can have the good extinction feeling, smooth feeling, velvet feeling, leather feeling and hydrophobicity, the production process is clean and environmentally friendly, and an application technique is simple and efficient.

The invention discloses a microsphere adsorbent for highly selective adsorption of Cr(VI). The microsphere adsorbent comprises sodium alginate microspheres and a Cr(VI) ion-imprinted adsorption layercoating the surfaces of the sodium alginate microspheres by grafting; the Cr(VI) ion-imprinted adsorption layer is formed through an ion surface imprinting method with thiosemicarbazide as a functional monomer. The invention further discloses a preparation method and application of the microsphere adsorbent for highly selective adsorption of Cr(VI). With thiosemicarbazide as the functional monomer, the microsphere adsorbent has the advantages of large specific surface area, high adsorption capacity and highly selective adsorption of Cr(VI) ions.

The invention relates to the technical field of polluted water body remediation, and particularly relates to removal of low-concentration phosphate, and especially provides a phosphorus removal material aiming to low-concentration phosphorus, and a preparation method and an application of same. The material is microspheres formed from sodium alginate and fly ash coated with the sodium alginate ina crosslinking manner. The preparation method includes: dissolving the sodium alginate in deionized water and adding fly ash to prepare the slurry; dropwise adding a mixed solution of LaCl3.nH2O and anhydrous CaCl2 to the slurry by using an injector with needle pore size being 2-3 mm for crosslinking to form the spheres; washing the spheres for several times with ultrapure water, and drying the product. The sodium alginate microspheres have strong adsorption effect on low-concentration phosphate pollution. The preparation method of the phosphorus removal material can solve the problem of recycling of the wastes well, is low in cost, and is simple in operation. The material has an excellent promotion and application prospect as an emergency treatment method for phosphorus exceeding standardof tail water of sewage plant and rivers.

The invention provides a sodium alginate microsphere filling material. The filling material is prepared from, by weight, 30-50 parts of sodium alginate, 5-15 parts of gelatin, 0.5-5 parts of chitosan, 0.1-3 parts of an adsorbing agent, 5-10 parts of a cross-linking agent and 100-200 parts of normal saline. High biocompatibility and mutual crosslinking of components of the sodium alginate microsphere filling material are realized, degradation of hyaluronic acid is effectively prevented, plasticity stability in body filling is realized, a great plastic effect is achieved, and the defect of proneness to causing biotoxicity in use of cross-linked hyaluronic acid is overcome.