93 results about "Sodium Alginate Microspheres" patented technology

The invention relates to a tea polyphenol sodium alginate microsphere and a preparation method and an application thereof, in particular to a novel tea polyphenol sodium alginate microsphere. The microsphere is prepared from the following components in parts by weight: 4-6 parts of sodium alginate, 1-2 parts of chitosan, 1-2 parts of porous silicon dioxide and 3-6 parts of tea polyphenols. The porous silicon dioxide is added into a tea polyphenol microsphere, so that the content of tea polyphenols in the microphone can be increased remarkably. The preparation method of the tea polyphenol microsphere includes a liquid dripping one-step method and a liquid dripping two-step method. The microsphere disclosed by the invention can be widely applied in various fields of health-care products and biological medicine, and can be used for reducing blood fat, treating adiposity, removing free radicals in an anti-oxidation way, and preventing and treating tumors.

The invention discloses a preparation method and application of sodium alginate microspheres. After reeds are washed, dried in air and crushed, reed powder is placed in a 600 DEG C muffle furnace (the environment is full of N2) to be subjected to pyrolysis for 2 h, after being cooled, the reed power is sieved through a 100-mesh sieve, and reed biochar is obtained after the reed powder is subjected to chlorohydric acid pickling. Meanwhile, sodium alginate is dissolved in deionized water to be prepared into a 4% sodium alginate solution. A 20g / L reed biochar aqueous solution and the sodium alginate solution are evenly mixed according to the volume ratio of 1:1, a mixed solution is dropped into a CaCl2 solution through a peristaltic pump, and reed biochar-sodium alginate microsphere adsorption materials are made. The sodium alginate microspheres are environment-friendly materials and low in cost, the preparation method is simple and easy to implement, specifications are uniform, the sodium alginate microspheres have a good adsorption effect on pentachlorophenol (PCP) and phenanthrene (Phe) and are easy to recycle and high in acid and alkali resistance. The preparation method can be used for waste water treatment and can also be used as growing carriers of microorganisms, algae and the like.

The invention relates to a temperature-sensitive in-situ gel preparation composition for intra-articular injection and a preparation method thereof, and belongs to the field of medicine preparations. The preparation method comprises the following steps: preparing diclofenac sodium-carrying sodium alginate microspheres by combining a microsphere technology with a temperature-sensitive gel technology, and then carrying the medicine-carrying microspheres in a chitosan / beta-sodium glycerophosphate temperature-sensitive in-situ gel system to obtain a diclofenac sodium in-situ gel preparation composition. The composition is in a liquid state at a room temperature, capable of being converted to a semi-solid gel at a body temperature and forming a medicine storeroom at a medication part after being partially injected to enter an articular cavity, and beneficial to slowly releasing the medicine, prolonging the time of staying at the injection part, of the medicine, and enhancing the efficacy. The composition disclosed by the invention can be used for treating arthritis diseases of rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and the like, as well as applicable to both diclofenac sodium and other arthritis treatment medicines of non-steroidal anti-inflammatory medicines, steroid hormone medicines, biological preparations and the like.

Vascular embolus of paclitaxel-sodium alginate microsphere and its preparation. The preparation of it consists of the following steps: preparing the solution of paclitaxel, sodium alginate and dilvalent metal cations such as BaCl2 or CaCl2 etc. by order; mixing the paclitaxel solution and sodium alginate solution, and then mixing them with the curing solution of BaCl2 or CaCl2 and the like. Then the obtained is the sodium alginate microshere vascular embolus containing paclitaxel. The carrier materials of the vascular embolus according to the invention are natural extracts and have good biocompatibility and re biodegradable; the side effect of the pharmaceutic loaded by them is minimal, and it is therefore suitable for the vascular embolism and chemotherapy against the tumor.

The invention discloses a sodium alginate microballoon vein suppository containing hemangioma-resisting medicant, a preparation method and an application thereof. The sodium alginate microballoon vein suppository comprises carrier sodium alginate and hemangioma-resisting medicant; the sodium alginate covers the hemangioma-resisting medicant; the weight ratio of the sodium alginate to the hemangioma-resisting medicant is 5:1-60:1; and the hemangioma-resisting medicant is pingyangmycin, sodium morrhuate, carbamide or bleocin. The raw materials used in the invention have favorable mechanical strength, biocompatibility, biological degradability and stability, have no organic solvent, and are basically harmless to functions of hemopoietic system and immune system, thereby suppository can be industrially produced.

The invention provides a displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent and a preparation method thereof, and relates to a blood vessel embolic agent and a preparation method thereof. An object of the invention is to solve the technical problems that a conventional drug-loaded sodium alginate microsphere blood vessel embolic agent has no X-ray visibility. The method comprises the steps of mixing a sodium alginate solution containing nano silver particles and an antineoplastic drug solution, mixing the above mixture with a solidifying liquid via a dropping method, and thus the displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent is obtained. The displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent has good visibility under X rays, is convenient for observing embolic degree, effectively prevents mistaken embolism, and at the same time, facilitates follow-up observation.

The invention provides a sodium alginate polymer which is generated by carrying out a polymerization reaction, which is initiated by free radicals, to sodium alginate with a monomer which contains anunsaturated double bond and an anionic group, and optionally, a crosslinking agent being poly-functionality water-soluble acrylate or acrylamide. Compared with a sodium alginate microsphere embolic agent on market, the sodium alginate polymer, being a carrier, can adsorb and carry a drug in vitro through ions, wherein the sodium alginate polymer is high in drug carrying capacity and can slowly release the drug in vivo, thus increasing local medicine concentration, prolonging action time of the drug, reducing systemic toxicity of the drug and further improving curative effect of the chemotherapy of the embolism. The invention also provides a novel sodium alginate blood vessel embolism chemotherapy composition, in which the sodium alginate polymer, as the embolic agent and medicine, can be co-delivered to a target blood vessel via a catheter, so that the curative effect of the chemotherapy medicine is fully achieved. The product is free of damage on surrounding normal tissue and can reduce relapse of the diseases.

The invention provides a sodium alginate microsphere vascular embolization agent and a preparation method of the sodium alginate microsphere vascular embolization agent. The preparation method of the sodium alginate microsphere vascular embolization agent comprises the following steps: (1) mixing an emulgator with a solvent to prepare a continuous phase; and (2) taking a sodium alginate solution as a discrete phase, taking a calcium chloride solution as a solidification solution, introducing the continuous phase, the discrete phase and the solidification solution into a micro-fluidic device for reacting to prepare the sodium alginate microsphere vascular embolization agent, wherein the flow of the discrete phase is controlled to be 0.1-10mL / h; the flow of the solidification solution is controlled to be 0.1-10mL / h; the flow of the continuous phase is controlled to be 1-20mL / h. The invention also provides a sodium alginate microsphere vascular embolization agent prepared by the method. The sodium alginate microsphere vascular embolization agent is uniform in particle diameter and controllable in size, can be solidified in situ, and has an excellent development prospect.

The invention provides a preparation method for medicine-carrying polypyrrole / sodium alginate gel. The method comprises the following steps: by taking a natural high polymer sodium alginate as a structural guiding agent, forming a monomer compound by virtue of electrostatic attraction between carboxyl in a sodium alginate molecular structure and an amino in a pyrrole monomer; preparing polypyrrole / sodium alginate microspheres through in-situ oxidative polymerization; and then forming the medicine-carrying polypyrrole / sodium alginate gel by virtue of rapid ion exchange reaction between the sodium alginate and calcium ions. The medicine-carrying polypyrrole / sodium alginate gel obtained by the method has excellent double response performances of pH and electric field.

The invention provides a preparation method of calcium alginate microspheres with a core-shell structure, and relates to a preparation method of polymer microspheres. The preparation method comprises the steps that firstly, 100 parts of a polyvinyl alcohol solution (10%) and 10-100 parts of a sodium alginate solution (0.1%-10%) are mixed to prepare a uniform mixed solution; secondly, 1-200 parts of load materials are stirred and added into the mixed solution until a uniform mixture is prepared; thirdly, the mixture is continuously and dropwise added into a borax aqueous solution with the concentration of 0.1%-10%, and microspheres with the diameter of 0.4-4 mm can be formed; finally, the microspheres are taken out to be added into a calcium chloride solution with the concentration of 1%-10% under the stirring condition, so that calcium alginate wrapping layers can be formed on the surfaces of the microspheres, and then the calcium alginate microspheres with the core-shell structure can be obtained. According to the preparation method, the calcium alginate microspheres with the core-shell structure and the good permeability, gelling property and biocompatibility are prepared, have the mechanical strength and are suitable for fields of industry, agriculture, biology, medical science and the like.

The invention discloses a preparation method for embedded nano material / quorum quenching enzyme composite spherules. The preparation method comprises the following steps: embedding embedded nano material / quorum quenching enzyme particles into a sodium alginate solution, thereby preparing sodium alginate microspheres; and coating a high polymer casting film solution added with graphene oxide, and preparing hydrogel composite spherules with organic shell and hydrogel kernel structures by use of a phase inversion method. The composite spherules are capable of inhibiting growth of a membrane-surface biological membrane by use of the bacterial signal molecule degrading function of a quenching enzyme; meanwhile, by use of the aperture, mechanical strength and antipollution characteristics of polymer shells, the erosion endurance and service lives of the composite spherules in MBR are enhanced, the spherule recovery rate is improved, and environmental pollution of nanophase materials is avoided. The embedded nano material / quorum quenching enzyme composite spherules can be widely applied to fields of biology, water treatment and the like.

The invention relates to a polyacrylamide modified Fe-Mn-S / sodium alginate composite microsphere and a preparation method thereof. The composite microsphere is composed of 22.3-78.6% of an iron-manganese-sulfur ternary porous material, 16.3-68.7% of sodium alginate, 0.2-5% of a cross-linking agent and 0.2-8% of a dispersing agent. The iron-manganese-sulfur ternary porous material is introduced into the sodium alginate microspheres, so that the specific surface area of the sodium alginate microspheres is effectively increased, and the problem of low heavy metal adsorption capacity of single sodium alginate is solved. The polyacrylamide modified Fe-Mn-S / sodium alginate composite microsphere prepared by the method is simple in technological process and convenient to control. The polyacrylamide-modified FeMnS / sodium alginate composite microsphere is widely applied to heavy metal treatment, and particularly has an obvious adsorption capacity for heavy metal chromium ions in a phosphoric acid solution, and the adsorption capacity is as high as 450mg / g.

The invention discloses a method for preparing pharmaceutical dextran and levulose by bi-enzyme immobilization coupled multistage membrane separation, which comprises the following steps: co-immobilizing dextran sucrase and dextranase in sodium alginate microspheres to obtain bi-enzyme-immobilized spheres; adding the bi-enzyme-immobilized spheres into a sucrose solution used as a substrate to form an immobilized bi-enzyme / sucrose reaction system; and after the reaction product is separated by a multistage membrane system composed of hyperfiltration membranes and a nanofiltration membranes, directly obtaining the pharmaceutical dextran in the hyperfiltration membrane separation stage, and obtaining the high-purity levulose solution in the last nanofiltration membrane separation stage, wherein the enzymes and macromolecular dextran contained in the trapped solution of the first-stage hyperfiltration membrane return to the immobilized bi-enzyme / sucrose reaction system to participate in the reaction again, thereby implementing cyclic utilization of the enzymes. The invention has the advantages of lower cost, environment friendliness, high safety and high efficiency, is simple to operate, implements oriented adjustable production of high-quality pharmaceutical dextran with target molecular weight, and obtains the high-purity high-added-value levulose byproduct.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention discloses antibacterial hydrogel, which is prepared from the following components: methacrylated chitosan and antibacterial microspheres, and the antibacterial microspheres are sodium alginate microspheres loaded with nano-silver, wherein a mass ratio of the methacrylated chitosan to the antibacterial microspheres is 10: (0.1-2). According to the preparation method, the nano-silver is loaded into the sodium alginate microspheres, so that the slow release of the nano-silver is realized. Meanwhile, the sodium alginate microspheres loaded with the nano-silver are added into the methacrylated chitosan hydrogel to form microsphere-containing antibacterial hydrogel, so that the antibacterial property of the material is greatly improved, the cytotoxicity of the nano-silver is reduced, and the release period of the nano-silver is as long as 10 days or longer. The antibacterial hydrogel disclosed by the invention is safe, non-toxic and good in antibacterial property, shows appropriate swelling and degradation behaviors, has excellent biocompatibility and mechanical properties, is biodegradable and bioabsorbable, and also has injectability and a hemostatic function.

The invention relates to polyvinyl alcohol hydrogel as well as a preparation method and application thereof and belongs to the technical field of high molecular hydrogel. The preparation method comprises the following steps of: dropwise adding oridonin into a sodium alginate microsphere solution; performing treating to obtain an oridonin / sodium alginate microsphere compound; carrying out EDC / NHS (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / N-hydroxysuccinimide) activation reaction to prepare a polyethylenimine derivative carrier for loading micro RNA (Ribonucleic Acid); finally, uniformly mixing the oridonin / sodium alginate microsphere compound and a micro RNA / polyethylenimine derivative carrier with a polyvinyl alcohol solution and repeatedly freezing and thawing to form ahydrogel material. According to the polyvinyl alcohol hydrogel, the oridonin / sodium alginate microsphere compound and the micro RNA / polyethylenimine derivative carrier loaded on the hydrogel have drug slow release and micro RNA regulation and control functions; the medicinal availability of the oridonin can be improved; the polyvinyl alcohol hydrogel has a gene treatment effect and can be appliedto skin wound dressing.

The invention discloses a hyperbranched polyamide modified sodium alginate microsphere for heavy metal ion adsorption and a preparation method thereof. The preparation method comprises the following steps: (1) adding a sodium alginate solution to a CaCl2 solution dropwise, stirring while adding and conducting crosslinking reaction; filtering and cleaning after the reaction is finished to obtain asodium alginate microsphere; (2) adding the sodium alginate microsphere to a glutaraldehyde solution, then adding hydrochloric acid to carry out aldehyde reaction and filtering and cleaning to obtainthe sodium alginate microsphere containing aldehyde groups on the surface; (3) adding the sodium alginate microsphere containing the aldehyde groups on the surface into a hyperbranched polyamide solution and filtering, cleaning and drying after the reaction to obtain the hyperbranched polyamide modified sodium alginate microsphere. According to the preparation method, a strategy of first balling of the sodium alginate and then grafting is adopted, so that the grafting groups can be completely exposed on the surface of the microsphere, and the utilization rate of the grafting groups is effectively increased.

The invention belongs to the technical field of material preparation, and more specifically relates to sodium alginate microsphere with a corrosion inhibitor being coated inside, and a preparation method and applications thereof. The particle size of the sodium alginate microsphere ranges from 20 to 30<mu>m. The sodium alginate microsphere is added into a water-based paint at a certain ratio for coating of the surface of metal, when cracking of a formed coating layer is caused, water molecules permeate, water-sensitive fracture of the sodium alginate microsphere with the corrosion inhibitor inside is caused, the corrosion inhibitor is released, and gel states are achieved; the released corrosion inhibitor is absorbed by the metal surface, metal corrosion is prevented, formed sodium alginate gel is used for filling gaps on the coating layer, so that anti-corrosion performance of the coating layer is improved, and the service life of the water-based coating layer is prolonged in a green and environmental-friendly manner.

The invention relates to a method for preparing phosphate-solubilizing microorganism sustained-release sodium alginate microspheres by using an acute hole method. The method includes, firstly, screening, enriching and domesticating to obtain a target phosphorus-solubilizing microbial flora; then mixing the target phosphorus-solubilizing microbial flora with a sodium alginate solution with a certain concentration to obtain a mixed bacterial solution; adding a proper amount of hole-forming agents into the mixed bacterial solution; dripping the mixed bacterial solution into a CaCl2 solution through pinholes with different hole diameters to form the microspheres; and finally, optionally, dispersing the obtained microspheres into a chitosan solution again to obtain the secondary-coated microbial sustained-release sodium alginate microspheres. The microspheres are smaller in particle size and more regular in shape, double coating makes the microspheres have better strength and less easy to crack; and the microspheres have the advantages of good slow release effect, long duration and the like. As the coating materials used are sodium alginate and chitosan which have good biocompatibilityand can be naturally degraded, so that pollution and damage to soil can not be caused.

The invention relates to injectable cartilage repairing hydrogel and a preparation method thereof and belongs to the technical field of biochemical engineering. The injectable cartilage repairing hydrogel with a long-lasting slow-release growth factor is successfully prepared from materials such as aminated chondroitin sulfate, oxidized dextran and a sealing growth factor, namely sodium alginate microspheres. With the adoption of the sodium alginate microspheres in the hydrogel, long-lasting slow release of the growth factor is achieved; in addition, the aminated chondroitin sulfate and the oxidized dextran form the hydrogel through a Schiff base reaction, so that the purpose of injection of the hydrogel can be achieved, and convenience can be brought to clinical operation. The injectablecartilage repairing hydrogel provided by the invention has good biocompatibility and a cartilage induction repairing capability, and has a remarkable promotion function on regeneration of damaged cartilage tissue.

The invention discloses a novel anti-transplantation immunological rejection J2-sodium alginate microsphere slow release immunosuppressive agent, a preparation method and application. The slow release immunosuppressive agent comprises a natural matrix material and is convenient for microsphere implantation. In the preparation, sodium alginate is used as a drug carrier, a J2 immunocompetent component is crosslinked, and the immunosuppressive agent is wrapped or adsorbed in microspheres through a microsphere liquid droplet generation device under the action of calcium ions. The preparation has targeting property to specific tissues and organs; the local action time of the drug can be prolonged; the bioavailability of the drug is improved; the toxic or side effect of a whole body can be reduced; and the immunosuppressive agent can be applied to immunosuppression of transplantation of heart, liver, kidney, lung, skin and cornea.

The invention provides clopidogrel sulfate solid tablets and a preparation method thereof. The clopidogrel sulfate solid tablets are characterized in that clopidogrel sulfate is wrapped by sodium alginate microspheres and cooperated with trimethylchlorosilane modified superfine silica powder, and the stable solid tablets are obtained. According to the clopidogrel sulfate solid tablets, clopidogrel hydrogen sulfate serves as a main drug and cooperated with microcrystalline cellulose, vitamin E, a filling agent, a disintegrating agent, a lubricating agent, the sodium alginate microspheres and the modified superfine silica powder. Due to the fact that trimethylchlorosilane surface modification treatment is conducted on the superfine silica powder with a hollow mesoporous structure, and the sodium alginate microspheres are utilized for wrapping clopidogrel sulfate and mixed with the modified superfine silica powder, the problem that in a clopidogrel sulfate solid preparation, clopidogrel is degraded into clopidogrel carboxylic acid, and a clopidogrel dextro isomer is converted into a laevo isomer is solved, the stability of clopidogrel tablets in the storage process and safety of the clopidogrel tablets in the medical use process are guaranteed, and the therapeutical effect of the clopidogrel tablets is exerted more effectively. The preparation technology is simple and particularly suitable for industrial production.

The invention provides a treatment method of printing and dyeing wastewater by combined adsorption, flocculation and membrane separation. The method comprises the following steps: firstly, separatelypreparing quaternized chitosan and sodium alginate microspheres, adding the quaternized chitosan and the sodium alginate microspheres into deionized water, and then dropwise adding a glutaraldehyde solution to carry out a cross-linking reaction to prepare a composite flocculant; preparing a zirconium oxide filter membrane by adopting a sol-gel method, then carrying out silanization treatment on the zirconium oxide filter membrane, and preparing a layer of yttrium-doped titanium oxide on the surface of the zirconium oxide filter membrane to form a composite nanofiltration membrane; and firstlycarrying out adsorption treatment on printing and dyeing wastewater by activated carbon, then adding the prepared composite flocculant into the treated wastewater for precipitation treatment, and finally carrying out nanofiltration treatment on the supernate subjected to flocculation treatment by the nanofiltration membrane, wherein the treated wastewater meets emission requirements. According tothe method, the method of combined adsorption, flocculation and membrane separation is adopted to treat the printing and dyeing wastewater, so that the removal rate of pollutants is high, pollution ofthe membrane in the treatment process is small, and the prepared nanofiltration membrane is excellent in mechanical property.

The invention provides a novel disease-resistant stress-resistant early senescence prevention fertilizer for adjusting crop growth. The novel disease-resistant stress-resistant early senescence prevention fertilizer for adjusting the crop growth is prepared from, by weight, 100 parts of urea, 60-80 parts of monopotassium phosphate, 5-15 parts of fulvic acid chelate microelement, 5-20 parts of diethyl aminoethyl hexanoate, 1-10 parts of 5-nitroguaiacol sodium salt and 5-20 parts of modified chitosan-kelp micro gelation.

The invention provides a multifunctional water-based surface treating agent for microfiber leather and a preparation method of the multifunctional water-based surface treating agent. The multifunctional water-based surface treating agent is prepared from the following components in parts by weight: 30-50 parts of water-based polycarbonate resin, 5-10 parts of sodium alginate microsphere emulsion,6-12 parts of modified polyurethane fluff powder dispersion liquid, 0.5-1.5 parts of a cross-linking agent, and 100-150 parts of water in an evenly-mixing mode. During using, the multifunctional water-based surface treating agent is coated on the surface of the microfiber leather in a rolled mode, the coating amount is controlled to be 15-45 g / m<2>, the drying temperature is 100-130 DEG C, and thedrying time is 2-5 minutes, and after the microfiber leather is cooled, the surface of the microfiber leather can have good extinction feeling, smooth feeling, velvet feeling, leather feeling and hydrophobicity. The multifunctional water-based surface treating agent is prepared by adopting a multiple modification compounding technology, the surface of the microfiber leather can have the good extinction feeling, smooth feeling, velvet feeling, leather feeling and hydrophobicity, the production process is clean and environmentally friendly, and an application technique is simple and efficient.

The invention discloses a microsphere adsorbent for highly selective adsorption of Cr(VI). The microsphere adsorbent comprises sodium alginate microspheres and a Cr(VI) ion-imprinted adsorption layercoating the surfaces of the sodium alginate microspheres by grafting; the Cr(VI) ion-imprinted adsorption layer is formed through an ion surface imprinting method with thiosemicarbazide as a functional monomer. The invention further discloses a preparation method and application of the microsphere adsorbent for highly selective adsorption of Cr(VI). With thiosemicarbazide as the functional monomer, the microsphere adsorbent has the advantages of large specific surface area, high adsorption capacity and highly selective adsorption of Cr(VI) ions.

The invention relates to the technical field of polluted water body remediation, and particularly relates to removal of low-concentration phosphate, and especially provides a phosphorus removal material aiming to low-concentration phosphorus, and a preparation method and an application of same. The material is microspheres formed from sodium alginate and fly ash coated with the sodium alginate ina crosslinking manner. The preparation method includes: dissolving the sodium alginate in deionized water and adding fly ash to prepare the slurry; dropwise adding a mixed solution of LaCl3.nH2O and anhydrous CaCl2 to the slurry by using an injector with needle pore size being 2-3 mm for crosslinking to form the spheres; washing the spheres for several times with ultrapure water, and drying the product. The sodium alginate microspheres have strong adsorption effect on low-concentration phosphate pollution. The preparation method of the phosphorus removal material can solve the problem of recycling of the wastes well, is low in cost, and is simple in operation. The material has an excellent promotion and application prospect as an emergency treatment method for phosphorus exceeding standardof tail water of sewage plant and rivers.

The invention provides a sodium alginate microsphere filling material. The filling material is prepared from, by weight, 30-50 parts of sodium alginate, 5-15 parts of gelatin, 0.5-5 parts of chitosan, 0.1-3 parts of an adsorbing agent, 5-10 parts of a cross-linking agent and 100-200 parts of normal saline. High biocompatibility and mutual crosslinking of components of the sodium alginate microsphere filling material are realized, degradation of hyaluronic acid is effectively prevented, plasticity stability in body filling is realized, a great plastic effect is achieved, and the defect of proneness to causing biotoxicity in use of cross-linked hyaluronic acid is overcome.

The invention discloses a preparation method of chlorophyll-sodium alginate microspheres. The method comprises the steps as follows: (1) preparing a sodium alginate solution; (2) adding lutein, magnesium stearate and liquid paraffin to the sodium alginate solution, performing stirring and ultrasonic treatment, passing a high-pressure homogenizer 3 times under the pressure of 30 MPa, and leaving the obtained solution to stand for 2-3 h to obtain a mixed emulsion; (3) dropwise adding the obtained mixed emulsion to a calcium chloride solution in a stirring state, after addition, performing stiring and suction filtration, washing the obtained material by distilled water 3 times, leaving the obtained material to stand for 24 h at room temperature, and performing vacuum drying. The prepared chlorophyll-sodium alginate microspheres have round appearance forms, porous performance and good dispersity and stability and can swell in a colon pH environment to release easily.