Marine plant extract induced tissue repair hydrogel wound dressing and preparation method thereof

A wound dressing and tissue repair technology, applied in bandages, medical science, etc., can solve the problems of not being able to cover most stages of wound healing, the ability to promote healing is not durable, and the effect is not ideal, so as to improve the toughness and integrity, and clear the wound Dirt, good effect of isolating bacteria

Pending Publication Date: 2022-04-26
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the single effect of traditional wound dressings cannot cover most stages of wound healing and the ability to promot...

Method used

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  • Marine plant extract induced tissue repair hydrogel wound dressing and preparation method thereof
  • Marine plant extract induced tissue repair hydrogel wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A marine plant extract-induced tissue repair hydrogel wound dressing and a preparation method thereof are composed of polyvinyl alcohol, carbomer, undecamide betaine, medical glycerin and growth factor-loaded alginate microspheres by mixing obtained in conjunction with growth factor-loaded alginate microspheres prepared by spray drying. The preparation method of the above-mentioned continuous healing-promoting hydrogel wound dressing is as follows:

[0022] S1. Preparation of growth factor-loaded alginate microspheres: dissolving sodium alginate (G / M=2:1) ​​in purified water to obtain a 2wt% alginate solution, and then adding alginate and alginate to the alginate solution The growth factor with a sodium mass ratio of 1:5 is stirred evenly to obtain a growth factor-containing alginate solution, and the growth factor-containing alginate solution is sprayed and dried in a freeze dryer to rapidly sublime the alginate-dissolved solution to form Growth factor-loaded alginate...

Embodiment 2

[0025] A marine plant extract-induced tissue repair hydrogel wound dressing and a preparation method thereof are composed of polyvinyl alcohol, carbomer, undecamide betaine, medical glycerin and growth factor-loaded alginate microspheres by mixing obtained in conjunction with growth factor-loaded alginate microspheres prepared by spray drying. The preparation method of the above-mentioned continuous healing-promoting hydrogel wound dressing is as follows:

[0026] S1. Preparation of growth factor-loaded alginate microspheres: dissolving sodium alginate (G / M=2:1) ​​in purified water to obtain a 2wt% alginate solution, and then adding alginate and alginate to the alginate solution The growth factor with a sodium mass ratio of 1:8 is stirred evenly to obtain a growth factor-containing alginate solution, and the growth factor-containing alginate solution is sprayed in a freeze dryer and dried, so that the solution dissolving alginate is rapidly sublimated to form Growth factor-lo...

Embodiment 3

[0029] A marine plant extract-induced tissue repair hydrogel wound dressing and a preparation method thereof are composed of polyvinyl alcohol, carbomer, undecamide betaine, medical glycerin and growth factor-loaded alginate microspheres by mixing obtained in conjunction with growth factor-loaded alginate microspheres prepared by spray drying. The preparation method of the above-mentioned continuous healing-promoting hydrogel wound dressing is as follows:

[0030] S1. Preparation of growth factor-loaded alginate microspheres: dissolving sodium alginate (G / M=2:1) ​​in purified water to obtain a 2wt% alginate solution, and then adding alginate and alginate to the alginate solution The growth factor with a sodium mass ratio of 1:8 is stirred evenly to obtain a growth factor-containing alginate solution, and the growth factor-containing alginate solution is sprayed in a freeze dryer and dried, so that the solution dissolving alginate is rapidly sublimated to form Growth factor-lo...

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Abstract

The invention belongs to the field of medical instruments, particularly relates to the field of medical biopolymer materials, and provides a marine plant extract induced tissue repair hydrogel wound dressing and a preparation method thereof.The marine plant extract induced tissue repair hydrogel wound dressing is obtained by mixing and crosslinking polyvinyl alcohol, carbomer, undecylamide betaine, medical glycerol and growth factor-loaded alginate microspheres; wherein the growth factor loaded alginate microspheres are prepared by a spray drying method. The marine plant extract induced tissue repair hydrogel wound dressing disclosed by the invention not only has relatively strong imbibition and moisturizing performance and excellent film-forming performance, but also has excellent antibacterial performance, wound dirt removal performance and excellent continuous healing promotion performance; the hydrophilic growth factor-loaded alginate microspheres in the hydrogel wound dressing are swelled along with imbibition of alginate after being in contact with blood or exudate, and the growth factors contained in the alginate microspheres are slowly released, so that the aim of continuously promoting healing is fulfilled.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of medical biopolymer materials, and particularly relates to a marine plant extract-induced tissue repair hydrogel wound dressing and a preparation method thereof. [0002] technical background [0003] With the sharp increase in the incidence of diabetes and cardiovascular disease in my country, the accelerated aging of society, and the increase in the occurrence of various chronic wounds, wound care has changed from the original focus on trauma and burns to the treatment of diabetes. Lord, chronic wound disease will become a major challenge facing our country. According to statistics, in the past ten years, chronic wounds caused by diabetes have surpassed burn wounds for the first time, ranking first in the cause of chronic wounds. growing point. [0004] However, traditional wound dressings cannot cover most of the stages of wound healing with a single efficacy, and th...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0028A61L26/0014A61L26/0066A61L26/008A61L2300/414A61L2300/214A61L2300/404C08L5/04C08L89/00C08L29/04C08L33/02
Inventor 陈锦涛吴帅罗华玲
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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