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A kind of developing embolic material and preparation method thereof

An embolization and microsphere technology, applied in X-ray contrast agent preparation, surgery, surgical adhesives, etc., can solve problems such as toxic side effects, ectopic embolism, deviation, etc., and achieve good biocompatibility, good embolization effect, The effect of good developing effect

Active Publication Date: 2020-07-03
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The separation of the contrast agent and the embolic material makes the development results observed under the imaging equipment not fully reflect the real situation of the embolic material, resulting in deviations
In addition, excessive free contrast agent will also have toxic side effects on the body
[0005] (2) Difficult to review
During embolization, too small particles of embolic agents are likely to leak from the blood vessels at the lesion site, enter the blood circulation and be trapped by the lungs, resulting in ectopic embolism; while too large particles will fail to reach the small blood vessels at the far end, resulting in poor embolization effect. completely
In addition, since the calibers of different blood vessels vary greatly, it is also a problem whether the same particle embolic agent can be made into different particle sizes according to the size of the embolization site.

Method used

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  • A kind of developing embolic material and preparation method thereof
  • A kind of developing embolic material and preparation method thereof
  • A kind of developing embolic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of barium sulfate-loaded barium alginate microspheres

[0040] Use 2% (w / v) sodium alginate and 0.3 mol / L sodium sulfate as the electrospray liquid into the sampling device of the electrostatic spray equipment, and adjust the sampling speed to 0.3 mL / hr. Use 0.6mol / L barium chloride solution as the collection solution, place it 9cm directly below the nozzle, and slowly stir the collection solution. The annular electric coil is placed 2cm below the nozzle to limit the spray range of the droplets. The inner diameter of the nozzle is 0.18mm. The nozzle is connected to a DC high-voltage power supply, and the regulated voltage is 10kv. The toroidal coil is connected to another high-voltage power supply, and the regulated voltage is 2kv. The ground wire of the collection vessel. When the DC high voltage power supply is turned on, the electrospray liquid is split into micron-sized droplets of uniform size by electrostatic force, and then reacts with the...

Embodiment 2

[0042] Example 2: Control of the particle size of the developed microspheres

[0043] The preparation method is the same as in Example 1. This embodiment is only used to list some examples to show that by simply adjusting the parameters of the electrostatic spray, monodisperse microspheres of different particle sizes can be obtained, which can be used for embolization of blood vessels of different calibers.

[0044] When keeping the other parameters of electrostatic spraying unchanged and only increasing the inner diameter of the nozzle, the particle size of the embolic microspheres will increase accordingly. Such as Figure 4 As shown, when the inner diameter of the nozzle increases from 0.18mm, 0.26mm, 0.41mm, 0.84mm to 1.19mm, the particle size of the microspheres increases from 160±7μm, 220±18μm, 320±17μm, 410±27μm. To 490±23μm. The morphology of the resulting developed microspheres is as Figure 5 As shown, 5A to 5E represent the optical micrographs of the developed microsph...

Embodiment 3

[0046] Example 3: Expansion of the preparation method of developing microspheres

[0047] The preparation method is the same as in Example 1. This embodiment is only used to list some examples to prove that the preparation method of the present invention is easy to expand.

[0048] Such as Figure 8 As shown, when keeping the other parameters of electrostatic spraying unchanged, and increasing the injection speed from 0.3mL / hr, 0.6mL / hr, 1mL / hr to 2mL / hr, the particle diameters of the resulting microspheres are 160±7μm and 164, respectively. ±9μm, 170±11μm, and 168±9μm. The morphology of the resulting developed microspheres is as Picture 9 As shown, 9A-9D substitute the optical micrographs of the developed microspheres prepared when the injection speeds are 0.3, 0.6, 1 and 2 mL / hr, respectively. The particle size and monodispersity of the microspheres did not change much. That is, when the yield is increased by about 10 times, the quality of the developed microspheres is still ...

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Abstract

The invention discloses a developing embolic material and a preparation method of the developing embolic material. Developable barium-alginate embolic microspheres encapsulating in-situ synthesis barium sulfate particles are prepared from one step by the adoption of an electrostatic spraying technology, integration of a developing agent and the embolic material is achieved, and the problems that when interventional therapy is clinically adopted, indirect developing exists and rechecking is difficult are solved. The mono-dispersion microspheres with the grain diameter being 100-1000 microns can be obtained by adjusting and controlling the electrostatic spraying parameter, so that the mono-dispersion microspheres with the grain diameter being 100-1000 microns are suitable for embolism of vessels of different calibers. The development agent, barium sulfate, and the barium-alginate microspheres are formed at the same time, and the barium sulfate particles are evenly distributed in the microspheres and firmly fixed. Extracorporeal simulation experiments prove that the developing microspheres are quite stable within the testing time of 50 days. A big-eared rabbit right kidney arterial embolism experiment proves that the developing microspheres have a good developing effect and an embolic effect. Because the electrostatic spraying technology has the characteristics of being simple, rapid and low in cost, the one-step preparation method has the production potential.

Description

Technical field [0001] The invention relates to a preparation method of developable embolic microspheres, in particular to one-step preparation of imageable barium alginate embolic microspheres containing in-situ synthetic barium sulfate particles by electrostatic spray technology. Background technique [0002] The whole process of vascular interventional therapy is carried out under the guidance and monitoring of imaging equipment. The embolic material is injected into the blood vessels of the diseased organ with the help of catheters, needles and other instruments inserted into the organs, interrupting blood flow, blocking nutrient supply to the diseased area, and inhibiting tumor Grow. It has the advantages of accurate direct access to the lesion, small wound, low risk, and quick recovery. It has been widely used in embolization treatment of tumors. [0003] However, the technology has the following problems in clinical use: [0004] (1) Lack of embolic material for auto-imaging...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61L24/08A61L24/02
CPCA61L24/001A61L24/0031A61L24/02A61L24/08C08L5/04
Inventor 杨祥良杜青李玲郑传胜刘宏
Owner HUAZHONG UNIV OF SCI & TECH
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