30results about How to "Meet the requirements of clinical application" patented technology

The invention relates to a preparation method of brushite bone cement. The preparation method comprises the following steps: preparing an acidic bone cement solidification liquid by adopting a citric acid solution as a main body and adopting phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifying agents; fully mixing monohydrate calcium dihydrogen phosphate, beta-tricalcium phosphate and SiO2 to obtain SiO2 modified brushite bone cement solid-phase powder; and mixing the bone cement solid-phase powder with the solidification liquid according to a solid-to-liquid ratio to obtain the brushite bone cement, wherein a solidification product comprises brushite as a main component. By adopting the preparation method disclosed by the invention, the solidification time of the brushite bone cement which adopts a conventional citric acid solution as the solidification liquid can be prolonged to be 6-20 minutes, and the flowability of blended slurry can be increased; and meanwhile, by virtue of complexing action of phosphorylated chitosan, solid-liquid separation of the blended slurry at a certain pressure can be avoided, and the comprehensive performance of the blended slurry can preferably meet the requirements of clinical application.

The invention relates to a sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel and a method for preparing the same.The method includes steps of carrying out low-temperature plasma surface pre-treatment on a polytetrafluoroethylene artificial blood vessel, vertically or obliquely arranging the polytetrafluoroethylene artificial blood vessel, sealing one end of the polytetrafluoroethylene artificial blood vessel, forming an opening in the other end of the polytetrafluoroethylene artificial blood vessel, keeping the opening upwards, injecting 0.5-2.0 mg/mL silk fibroin solution into the polytetrafluoroethylene artificial blood vessel from the opening, evaporating the silk fibroin solution and coating the silk fibroin solution in the polytetrafluoroethylene artificial blood vessel; turning the polytetrafluoroethylene artificial blood vessel over, keeping the opening upwards, injecting 0.5-2.0 mg/mL silk fibroin solution into the polytetrafluoroethylene artificial blood vessel from the opening, evaporating the silk fibroin solution and coating the silk fibroin solution in the polytetrafluoroethylene artificial blood vessel to obtain a silk fibroin film modified polytetrafluoroethylene artificial blood vessel, and carrying out low-temperature plasma surface sulfonation treatment on the silk fibroin film modified polytetrafluoroethylene artificial blood vessel to obtain the sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel.The sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel and the method have the advantages that the sulfonated silk fibroin film modified polytetrafluoroethylene artificial blood vessel prepared by the aid of the method is good in uniformity and excellent in blood and tissue compatibility and rarely has chap and crack.

The invention provides an intermediate compound, and a synthetic method and an application for the intermediate compound. The method comprises the following steps: adding a compound 1 and dimethylammonium hydrochloride into a solvent mixed by dimethylsulfoxide and water, adding K2CO3 for two times or more, and carrying out a reflux reaction under heating for 6 h to 36 h, wherein the mol ratio of the compound 1 to the dimethylammonium hydrochloride to the K2CO3 is 1: (1-5): (1-5); and after completion of the reaction, carrying out separation and purification so as to obtain the intermediate compound. The intermediate compound provided by the invention is mainly applied to F-BPA nucleophilic fluorination synthesis.

The invention provides an intermediate compound, and a synthetic method and an application for the intermediate compound. The method comprises the following steps: dissolving a compound 4 in water, then adding an obtained mixture into a tC18 column, flushing the column with water, and carrying out blowing with gas so as to discharge an excess liquid; adding an NaBH4 aqueous solution, carrying outa reaction for 2 minutes or above, flushing the column with water, and carrying out blowing with gas so as to discharge an excess liquid; and adding an HI aqueous solution, carrying out a reaction for2 minutes or above, discharging an excess liquid by using gas, and carrying out elution with toluene so as to obtain an intermediate compound dissolved toluene solution, wherein the mole ratio of thecompound 4 to NaBH4 to HI is 1: (1-5): (1-5). The intermediate compound provided by the invention is mainly applied to F-BPA nucleophilic fluorination synthesis.