Preparation method of high-strength hydroxyapatite bone cement

A technology of hydroxyapatite and hydroxyapatite powder, applied in medical science, prosthesis, etc., can solve the problems of low compressive strength, large amount of heat release, limited operating time, etc., and achieve the effect of excellent comprehensive performance

Active Publication Date: 2016-08-17
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, the first-generation bone cement has problems such as poor biocompatibility, a large amount of heat release during solidification and polymerization, cytotoxicity of monomers, and limited operability time; the second-generation calcium phosphate bone cement has problems such as The acid-base reaction will change the pH value of the body fluid around the bone cement, and the compressive strength is relatively low; the highest compressive strength of the new generation of bone cement proposed by Japanese scholar Mamoru Aizawa has only reached the level of cancellous bone, and cannot be used for Stressed parts or weak bones

Method used

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  • Preparation method of high-strength hydroxyapatite bone cement
  • Preparation method of high-strength hydroxyapatite bone cement
  • Preparation method of high-strength hydroxyapatite bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] step one:

[0033] 1) Weigh 10g of hydroxyapatite powder;

[0034] 2) Configure a phytic acid solution with a concentration of 10000ppm: weigh 1.43g of a phytic acid solution with a mass concentration of 70%, add distilled water to it to make 40ml, adjust its pH value to about 7.3 with 0.1mol / L NaOH solution, Finally, distill the solution to 50ml with distilled water to obtain 50ml of phytic acid solution with a concentration of 10000ppm;

[0035] 3) Put the weighed hydroxyapatite powder and the prepared phytic acid solution in a ball mill tank, and perform ball milling on the powder at room temperature to modify simultaneously, wherein the mass ratio of phytic acid to hydroxyapatite is 0.05 , the ball milling time is controlled to be 2h, and the slurry is obtained after ball milling;

[0036] Step two:

[0037] Suction filtration, distilled water washing and vacuum freeze-drying are performed on the slurry obtained after ball milling to obtain hydroxyapatite powder ...

Embodiment 2

[0044] step one:

[0045] 1) Weigh 10g of hydroxyapatite powder;

[0046] 2) configuration concentration is the phytic acid solution of 7000ppm, and operation steps are with embodiment 1;

[0047] 3) Put the weighed hydroxyapatite powder and the prepared phytic acid solution in a ball milling tank, and simultaneously modify the powder by ball milling at room temperature, wherein the mass ratio of phytic acid to hydroxyapatite is 0.035 , the ball milling time is controlled to be 4h, and the slurry is obtained after ball milling;

[0048] Step two:

[0049] Suction filtration, distilled water washing and vacuum freeze-drying are performed on the slurry obtained after ball milling to obtain hydroxyapatite powder surface-modified with 7000 ppm phytic acid solution after ball milling for 4 hours.

[0050] Step three:

[0051] 1) configuration mass concentration is 20% citric acid aqueous solution, operation steps are with embodiment 1.

[0052] 2) Mix the hydroxyapatite powder s...

Embodiment 3

[0056] step one:

[0057] 1) Weigh 10g of hydroxyapatite powder;

[0058] 2) Configure a phytic acid solution with a concentration of 1000ppm, and the operation steps are the same as in Example 1.

[0059] 3) Put the weighed hydroxyapatite powder and the prepared phytic acid solution in a ball mill tank, and simultaneously modify the powder by ball milling at room temperature, wherein the mass ratio of phytic acid to hydroxyapatite is 0.005 , the ball milling time is controlled to be 2h, and the slurry is obtained after ball milling;

[0060] Step two:

[0061] Suction filtration, distilled water washing and vacuum freeze-drying are performed on the slurry obtained after ball milling to obtain hydroxyapatite powder surface-modified by 1000 ppm phytic acid solution after ball milling for 2 hours.

[0062] Step three:

[0063] 1) configuration mass concentration is 10% citric acid aqueous solution, operation steps are with embodiment 1.

[0064] 2) Mix the hydroxyapatite po...

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Abstract

The invention relates to a method for preparing high-strength novel hydroxyapatite bone cement. The method comprises the following step of blending single-phase hydroxyapatite powder, which is subjected to surface modification by virtue of a phytic acid solution, as solid powder and a low-concentration citric acid aqueous solution as a curing liquid at a certain solid-liquid ratio to obtain the high-strength novel hydroxyapatite bone cement. The bone cement has higher compressive strength which can reach up to 66MPa and is much higher than that of the bone cement using existing single-phase hydroxyapatite as the solid powder, good biocompatibility and operability, the curing process does not rely on an acid-base reaction and the heat release rate is very low, the bone cement is neutral and the excellent performance meets the requirements of clinical applications and the hydroxyapatite bone cement can be applicable to the repair of hard tissue bone defects, treatment of osteoporosis and fixation and treatment of bone fracture.

Description

Technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a novel high-strength hydroxyapatite bone cement and a preparation method thereof. Background technique [0002] At present, bone cement has been widely used clinically as a bone filling and repair material, which mainly includes the first-generation bone cement represented by polymethyl methacrylate bone cement and the second-generation calcium phosphate bone cement. Calcium phosphate bone cement overcomes the poor biocompatibility of the first generation of bone cement, a large amount of heat release during solidification and polymerization, monomer cytotoxicity, and limited operability time. However, the curing of calcium phosphate bone cement is based on the calcium phosphate between The acid-base reaction (that is, hydration) is carried out, and the pH value of the body fluid around the bone cement will change during the curing process, which will ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50
Inventor 汪涛祁燕杨心王阳阳
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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