Preparation method of high-strength hydroxyapatite bone cement

A technology of hydroxyapatite and hydroxyapatite powder, applied in medical science, prosthesis, etc., can solve the problems of low compressive strength, large amount of heat release, limited operating time, etc., and achieve the effect of excellent comprehensive performance
CN104524627BActive Publication Date: 2016-08-17NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Publication Date
2016-08-17

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Abstract

The invention relates to a method for preparing high-strength novel hydroxyapatite bone cement. The method comprises the following step of blending single-phase hydroxyapatite powder, which is subjected to surface modification by virtue of a phytic acid solution, as solid powder and a low-concentration citric acid aqueous solution as a curing liquid at a certain solid-liquid ratio to obtain the high-strength novel hydroxyapatite bone cement. The bone cement has higher compressive strength which can reach up to 66MPa and is much higher than that of the bone cement using existing single-phase hydroxyapatite as the solid powder, good biocompatibility and operability, the curing process does not rely on an acid-base reaction and the heat release rate is very low, the bone cement is neutral and the excellent performance meets the requirements of clinical applications and the hydroxyapatite bone cement can be applicable to the repair of hard tissue bone defects, treatment of osteoporosis and fixation and treatment of bone fracture.
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Description

Technical field

[0001] The invention relates to a method in the technical field of biomedical materials, in particular to a novel high-strength hydroxyapatite bone cement and a preparation method thereof. Background technique

[0002] At present, bone cement has been widely used clinically as a bone filling and repair material, which mainly includes the first-generation bone cement represented by polymethyl methacrylate bone cement and the second-generation calcium phosphate bone cement. Calcium phosphate bone cement overcomes the poor biocompatibility of the first generation of bone cement, a large amount of heat release during solidification and polymerization, monomer cytotoxicity, and limited operability time. However, the curing of calcium phosphate bone cement is based on the calcium phosphate between The acid-base reaction (that is, hydration) is carried out, and the pH value of the body fluid around the bone cement will change during the curing process, which will ca...

Claims

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