Calcium phosphate bone cement degraded by temperature regulation and its preparation method

Abstract

The invention discloses a calcium phosphate bone cement subjected to temperature regulation degradation, wherein the preparation raw materials comprise calcium phosphate bone cement liquid phase agentand solid phase powder which are matched when used; the liquid phase agent is a common calcium phosphate bone cement liquid phase agent; the solid phase powder is a mixture of a temperature-sensitiveoxygen generating compound and common calcium phosphate cement solid phase powder; the temperature-sensitive oxygen generating compound is a sodium percarbonate-wax microsphere compound coated with alayer of gelatin on the surface, the sodium percarbonate-wax microsphere compound is a sodium percarbonate microsphere compound coated with a layer of wax on the surface. The invention also disclosesa preparation method of the calcium phosphate bone cement subjected to temperature regulation degradation, the degradation rate of the calcium phosphate bone cement can be accelerated through heat treatment, and the calcium phosphate bone cement has good safety performance and is suitable for mass production.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a calcium phosphate bone cement degraded by temperature control and a preparation method thereof. Background technique [0002] Calcium phosphate bone cement is a biomedical material that can not only help the repair and reconstruction of human hard tissues, but also serve as a carrier for drug release. Calcium phosphate bone cement has the advantages of easy preparation and arbitrary shaping. Compared with other bone cements, it has better biocompatibility, does not generate heat during solidification and crystallization, and has higher safety. However, the in vivo degradation rate of the existing calcium phosphate bone cement is relatively slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro. At present, th...

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Problems solved by technology

However, the degradation rate of the existing calcium phosphate bone cement in vivo is slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro

At present, methods and products that can change the degradation rate of calcium phosphate bone cement through heat in vitro have not been reported yet.

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