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A kind of preparation method of acidic hydroxyapatite catalyzed solidification bone cement

A technology of acidic hydroxyapatite and hydroxyapatite, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of increasing biocompatibility, prolong the curing time, be suitable for mass production, and improve reliability injectable effect

Active Publication Date: 2018-07-13
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface-modified nano-hydroxyapatite can catalyze the solidification of brushite bone cement, improve the cytotoxicity of the original brushite acidic curing solution, and increase the poor biocompatibility

Method used

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  • A kind of preparation method of acidic hydroxyapatite catalyzed solidification bone cement
  • A kind of preparation method of acidic hydroxyapatite catalyzed solidification bone cement
  • A kind of preparation method of acidic hydroxyapatite catalyzed solidification bone cement

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 0.2g phosphorylated chitosan, 0.2g gelatin, 0.2g hydroxypropyl methylcellulose, dissolve in 19.4g 20wt% sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan Sugar, 1% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution. β-tricalcium phosphate, calcium dihydrogen phosphate monohydrate and modified hydroxyapatite were mixed at a ratio of 7:3, and the bone cement powder and curing liquid were mixed at a solid-liquid ratio of 1.5g / mL, referring to the standard ASTM The initial setting time of C191 was determined to be 80 min.

Embodiment 2

[0035]Weigh 0.2g phosphorylated chitosan, 0.2g gelatin, 0.2g hydroxypropyl methylcellulose, dissolve in 19.4g 20wt% sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan Sugar, 1% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution. β-tricalcium phosphate, calcium dihydrogen phosphate monohydrate and modified hydroxyapatite were mixed in a ratio of 7:3:0.5, and the bone cement powder and curing liquid were mixed at a solid-liquid ratio of 1.5g / mL. The initial setting time measured by the standard ASTM C191 is 60 minutes, and the injectability is good, and solid-liquid separation does not occur under a certain pressure.

Embodiment 3

[0037] Weigh 0.2g phosphorylated chitosan, 0.2g gelatin, 0.2g hydroxypropyl methylcellulose, dissolve in 19.4g 20wt% sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan Sugar, 1% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution. β-tricalcium phosphate, calcium dihydrogen phosphate monohydrate and modified hydroxyapatite were mixed in a ratio of 7:3:1, and the bone cement powder and curing liquid were mixed at a solid-liquid ratio of 1.5g / mL. The initial setting time measured by the standard ASTM C191 is 34 minutes. It has good injectability, and solid-liquid separation does not occur under a certain pressure.

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Abstract

The invention relates to a preparation method of bone cement catalytically cured by acidic HA (hydroxyapatite). According to the method, calcium phosphate monobasic monohydrate, beta-tricalcium phosphate and citric acid-modified HA are mixed, and modified brushite bone cement solid-phase powder is obtained, wherein the modified HA plays a catalytic curing role; sodium phosphate serves as a main body, phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin serve as a modifying agent, a neutral bone cement curing liquid is prepared, and an original acidic formula is improved; the bone cement solid-phase powder and the curing agent are mixed in a certain solid-to-liquid ratio, and a curing product comprises main components including brushite and HA and has the higher degradation ability in organisms. Used raw materials are simple, the preparation process is simple, and large-scale production can be realized. The bone cement formula has the significant improvement effect on curing time and syringeability of brushite bone cement and has broad application prospect in the field of clinical bone tissue repair.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials. Specifically, β-tricalcium phosphate and calcium dihydrogen phosphate monohydrate with a determined particle size are used as the basic matrix, and citric acid-modified nano-hydroxyapatite is added in proportion. It exists as a catalyst for the curing reaction and as a filler to enhance biocompatibility. The solidification solution part is to add phosphorylated chitosan, hydroxypropyl methylcellulose, gelatin and other components to the neutral sodium hydrogen phosphate solution to improve the characteristics of the original acidic bone cement. Background technique [0002] The repair and treatment of bone defects has long been a thorny problem for surgeons. Scientists from all over the world have been committed to the research and development of ideal bone repair biomaterials. Many bone diseases, such as tumors, traumatic nonunions, inflammations, and deformities, requi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/12A61L27/58
CPCA61L27/12A61L27/26A61L27/58A61L2400/06A61L2430/02C08L5/08C08L1/284C08L89/06
Inventor 何丹农严一楠姜杰王萍
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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